Present Status and Future Prospects for HIV Therapies

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

Infectious Diseases

1992 • 2,868 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

1985 • 1,830 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

A new type of synthetic peptide library for identifying ligand-binding activity

1991 • 1,769 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

1990 • 1,288 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)

1983 • 1,222 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

The Immunopathogenesis of Human Immunodeficiency Virus Infection

1993 • 1,194 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

1986 • 1,032 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

A controlled trial

1971 • 982 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

Antiviral Activity of 1-Adamantanamine (Amantadine)

1964 • 805 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

1990 • 740 citations

Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

1986 • 730 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis

1977 • 691 citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

1991 • 686 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

The Safety and Efficacy of Zidovudine (AZT) in the Treatment of Subjects with Mildly Symptomatic Human Immunodeficiency Virus Type 1 (HIV) Infection

1990 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

ASSOCIATION BETWEEN BIOLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUS VARIANTS AND RISK FOR AIDS AND AIDS MORTALITY

1989 • 581 citations

Plasma Viremia in Human Immunodeficiency Virus Infection

1989 • 575 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum

1992 • 531 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

Quantitation of human immunodeficiency virus type 1 infection kinetics

1993 • 516 citations

Lymphoid organs function as major reservoirs for human immunodeficiency virus.

1991 • 489 citations

Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

1990 • 471 citations

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

1993 • 464 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

THE ROLE OF ANTISENSE RNA IN GENE REGULATION

1986 • 456 citations

Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.

1988 • 450 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

1992 • 429 citations

In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

1989 • 426 citations

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA.

1991 • 405 citations

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

1991 • 391 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA

1991 • 376 citations

Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity

1989 • 373 citations

Ordered Appearance of Zidovudine Resistance Mutations during Treatment of 18 Human Immunodeficiency Virus-Positive Subjects

1992 • 369 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Regulation of human immunodeficiency virus env expression by the rev gene product

1989 • 365 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

A Controlled Trial Comparing Continued Zidovudine with Didanosine in Human Immunodeficiency Virus Infection

1992 • 347 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

The HIV-1 Protease as a Therapeutic Target for AIDS

1992 • 343 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine.

1991 • 330 citations

CD4+ Lymphocyte Cell Enumeration for Prediction of Clinical Course of Human Immunodeficiency Virus Disease: A Review

1992 • 313 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.

1986 • 303 citations

HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus

1989 • 299 citations

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

1991 • 289 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes

1991 • 278 citations

A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity.

1992 • 275 citations

Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp41-derived peptide and patients' sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immune deficiency syndrome.

1988 • 268 citations

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes

1992 • 266 citations

Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells

1992 • 261 citations

Once-Daily Administration of 2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 253 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication.

1991 • 245 citations

Primary Infection with Zidovudine-Resistant Human Immunodeficiency Virus Type 1

1993 • 245 citations

(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

1992 • 243 citations

The Effect of Cytokines and Pharmacologic Agents on Chronic HIV Infection

1992 • 237 citations

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1992 • 236 citations

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.

1988 • 235 citations

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

1990 • 234 citations

High-Efficiency Gene Transfer Mediated by Adenovirus Coupled to DNA–Polylysine Complexes

1992 • 234 citations

Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells.

1993 • 230 citations

Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

1988 • 227 citations

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

1988 • 227 citations

Ribozyme mediated destruction of RNA in vivo.

1989 • 223 citations

Interferon-α in Patients with Asymptomatic Human Immunodeficiency Virus (HIV) Infection

1990 • 221 citations

Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat Antagonist

1991 • 220 citations

Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozyme.

1992 • 220 citations

Phosphorodithioate DNA as a Potential Therapeutic Drug

1993 • 219 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.

1989 • 214 citations

9-(2-phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

1991 • 214 citations

The Effects on Survival of Early Treatment of Human Immunodeficiency Virus Infection

1992 • 213 citations

Structure-based, C2 symmetric inhibitors of HIV protease

1990 • 213 citations

Dual-target Inhibition of HIV-1 in Vitro by Means of an Adeno-Associated Virus Antisense Vector

1992 • 206 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine

1992 • 200 citations

Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

1989 • 200 citations

Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I infected individuals.

1990 • 197 citations

Integration is essential for efficient gene expression of human immunodeficiency virus type 1

1993 • 195 citations

Combination Therapy with Zidovudine and Dideoxycytidine in Patients with Advanced Human Immunodeficiency Virus Infection

1992 • 193 citations

Antiviral activities of hypericin

1991 • 191 citations

Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.

1993 • 189 citations

Antiviral properties of Ro 31-8959, an inhibitor of human immunodeficiency virus (HIV) proteinase

1991 • 186 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

1990 • 186 citations

Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.

1992 • 181 citations

A novel, dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site

1991 • 180 citations

Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1990 • 180 citations

2',3'-Didehydro-3'-deoxythymidine (d4T) in Patients with AIDS or AIDS-Related Complex: A Phase I Trial

1993 • 167 citations

Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease

1992 • 166 citations

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

1991 • 166 citations

Point mutations in conserved amino acid residues within the C‐terminal domain of HIV‐1 reverse transcriptase specifically repress RNase H function

1989 • 165 citations

A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.

1993 • 163 citations

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

1992 • 163 citations

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

1991 • 161 citations

Transcriptional but not translational regulation of HIV-1 by the tat gene product

1988 • 158 citations

Use of evolutionary limitations of HIV-1 multidrug resistance to optimize therapy

1993 • 156 citations

Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin

1993 • 155 citations

In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

1992 • 155 citations

Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine

1992 • 155 citations

Effect of zidovudine and Pneumocystis carinii pneumonia prophylaxis on progression of HIV-1 infection to AIDS

1991 • 153 citations

Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals.

1989 • 151 citations

Gene transfer into human lymphocytes by a defective human immunodeficiency virus type 1 vector

1991 • 150 citations

Pharmacokinetics, toxicity, and activity of intravenous dextran sulfate in human immunodeficiency virus infection

1991 • 149 citations

Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation

1991 • 148 citations

Hydroxyethylamine analogs of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease

1990 • 144 citations

Synergism Between HIV gp120 and gp120-Specific Antibody in Blocking Human T Cell Activation

1989 • 135 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase.

1992 • 130 citations

A Mutation in Human Immunodeficiency Virus Reverse Transcriptase and Decline in CD4 Lymphocyte Numbers in Long-Term Zidovudine Recipients

1993 • 129 citations

Commentary from Westminster

1983 • 126 citations

The safety and pharmacokinetics of a reverse transcriptase inhibitor, 3TC, in patients with HIV infection

1992 • 123 citations

HIV-1-Infected T Cells Show a Selective Signaling Defect After Perturbation of CD3/Antigen Receptor

1988 • 116 citations

Therapy may explain recent deficits in AIDS incidence.

1990 • 116 citations

Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase

1990 • 114 citations

Inhibition of Human Immunodeficiency Virus Type I (HIV-I) Replication by the Dipyridodiazepinone BI-RG-587

1991 • 112 citations

A rapid in vitro assay for HIV DNA integration

1991 • 110 citations

Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells [see comments]

1991 • 110 citations

2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors

1991 • 109 citations

Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors.

1991 • 108 citations

Minireview: Induction of Expression of HIV in Latently or Chronically Infected Cells

1989 • 107 citations

Functional analysis of HIV-1 reverse transcriptase amino acids involved in resistance to multiple nonnucleoside inhibitors.

1992 • 107 citations

Frequent Detection of HIV-1-Specific mRNAs in Infected Individuals Suggests Ongoing Active Viral Expression in All Stages of Disease

1991 • 104 citations

Effects of Initiation of 3'-Azido,3'-Deoxythymidine (Zidovudine) Treatment at Different Times after Infection of Rhesus Monkeys with Simian Immunodeficiency Virus

1993 • 104 citations

HIV-1 biological phenotype and the development of zidovudine resistance in relation to disease progression in asymptomatic individuals during treatment

1992 • 97 citations

Computer-assisted structure-activity correlations of dideoxynucleoside analogs as potential anti-HIV drugs

1990 • 96 citations

Scientific and Social Issues of Human Immunodeficiency Virus Vaccine Development

1993 • 95 citations

Two mechanisms of soluble CD4 (sCD4)-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) infectivity and their relation to primary HIV-1 isolates with reduced sensitivity to sCD4

1993 • 94 citations

Double-blind controlled trial of topical acyclovir in genital herpes simplex virus infections

1982 • 92 citations

AIDS pathogenesis: HIV envelope and its interaction with cell proteins

1990 • 92 citations

Replication of human immunodeficiency virus 1 and Moloney murine leukemia virus is inhibited by different heteroatom-containing analogs of myristic acid.

1989 • 92 citations

Phosphorylation, anti-HIV activity and cytotoxicity of 3′-fluorothymidine

1988 • 88 citations

Quantitation of zidovudine-resistant human immunodeficiency virus type 1 in the blood of treated and untreated patients.

1993 • 85 citations

Human immunodeficiency virus protease: A target for aids therapy

1990 • 83 citations

Prolonged immunostimulatory effect of low-dose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection.

1993 • 82 citations

Cytotoxic T lymphocytes from HIV-1 seropositive individuals recognize immunodominant epitopes in Gp160 and reverse transcriptase.

1992 • 81 citations

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

1992 • 79 citations

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

1990 • 77 citations

T-cell homeostasis: implications in HIV infection .

1993 • 76 citations

Human Immunodeficiency Virus Type 1 (HIV-1) Inhibitory Interactions between Protease Inhibitor Ro 31-8959 and Zidovudine, 2',3'-Dideoxycytidine, or Recombinant Interferon- A against Zidovudine-Sensitive or -Resistant HIV-1 In Vitro

1992 • 74 citations

Syngeneic Bone Marrow Transplantation and Adoptive Transfer of Peripheral Blood Lymphocytes Combined with Zidovudine in Human Immunodeficiency Virus (HIV) Infection

1990 • 72 citations

Safety and Effects of Interleukin-2 Plus Zidovudine in Asymptomatic Individuals Infected with Human Immunodeficiency Virus

1991 • 71 citations

Incorporation of 12-methoxydodecanoate into the human immunodeficiency virus 1 gag polyprotein precursor inhibits its proteolytic processing and virus production in a chronically infected human lymphoid cell line.

1991 • 70 citations

Loss of infectivity by progeny virus from alpha interferon-treated human immunodeficiency virus type 1-infected T cells is associated with defective assembly of envelope gp120

1992 • 69 citations

Effect of Interferon on Murine Leukaemia Virus Infection. IV. Formation of Non-infectious Virus in Chronically Infected Cells

1979 • 67 citations

Inhibition of HIV protease activity by heterodimer formation

1991 • 65 citations

The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase.

1992 • 62 citations

National AIDS incidence trends and the extent of zidovudine therapy in selected demographic and transmission groups.

1991 • 62 citations

Prevention of the spread of HIV-1 infection with nonnucleoside reverse transcriptase inhibitors

1992 • 61 citations

Signaling by lymphocyte function-associated antigen 1 (LFA-1) in B cells: enhanced antigen presentation after stimulation through LFA-1.

1992 • 60 citations

In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations

1992 • 59 citations

A Phase I/II Trial of Zidovudine, Interferon- , and Granulocyte-Macrophage Colony-Stimulating Factor in the Treatment of Human Immunodeficiency Virus Type 1 Infection

1991 • 58 citations

Quantitative Analysis of HIV-1 Proviral DNA in Peripheral Blood Mononuclear Cells from Patients with AIDS or ARC: Decrease of Proviral DNA Content Following Treatment with 2′,3′-Dideoxyinosine (ddI)

1990 • 58 citations

Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate

1991 • 56 citations

Inhibition of type 1 human immunodeficiency virus replication by a tat antagonist to which the virus remains sensitive after prolonged exposure in vitro.

1993 • 56 citations

Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis

1992 • 51 citations

Retroviral Vectors Expressing Soluble CD4: A Potential Gene Therapy for AIDS

1990 • 51 citations

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication.

1993 • 50 citations

Incidence of Zidovudine-Resistant Human Immunodeficiency Virus Isolated from Patients before, during, and after Therapy

1992 • 49 citations

Safety and tolerance of dideoxycytidine as a single agent

1990 • 48 citations

Induction of HIV-Specific CTL and Antibody Responses in Mice Using Retroviral Vector-Transduced Cells

1991 • 45 citations

Eighth International Conference on AIDS

1992 • 43 citations

Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in cocultured lymphocytes

1992 • 42 citations

Design and synthesis of HIV protease inhibitors. Variations of the carboxyterminus of the HIV protease inhibitor L-682,679

1991 • 41 citations

Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase.

1992 • 39 citations

L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro

1992 • 37 citations

Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity

1989 • 35 citations

Characterization of the double stranded RNA dependent RNase activity associated with recombinant reverse transcriptases

1992 • 33 citations

Novel fatty acyl substrates for myristoyl-CoA:protein N-myristoyl-transferase.

1990 • 33 citations

Cross-reactive lysis of human targets infected with prototypic and clinical human immunodeficiency virus type 1 (HIV-1) strains by murine anti-HIV-1 IIIB env-specific cytotoxic T lymphocytes

1993 • 32 citations

Pharmacokinetics of R 82913 in patients with AIDS or AIDS-related complex

1991 • 32 citations

Genetic structure and regulation of HIV

1991 • 30 citations

Searching for Markers on the AIDS Trail

1992 • 28 citations

Effect of dosing frequency on ZDV prophylaxis in macaques infected with simian immunodeficiency virus.

1993 • 26 citations

Thymidine and zidovudine metabolism in chronically zidovudine-exposed cells in vitro

1991 • 26 citations

T-deficient transmembrane signaling in CD4+ T cells of retroviral-induced immune-deficient mice.

1992 • 25 citations

Maintenance of CD4+ cells by thymopentin in asymptomatic HIV-infected subjects

1992 • 23 citations

MiniReview: Antiviral Targets Series, Number 1

1990 • 23 citations

HIV proteinase as a target for drug action

1989 • 23 citations

Innovations in Antiviral Development and the Detection of Virus Infections

1992 • 19 citations

The role of alpha-interferon in patients with human immunodeficiency virus infection.

1991 • 18 citations

Transdominant inhibition of wild-type human immunodeficiency virus type 2 replication by an envelope deletion mutant

1993 • 16 citations

Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in T lymphocytes requires CD4-gp120 binding

1992 • 12 citations

Transplacental Antiretroviral Therapy with 9-(2-Phosphonylmethoxyethyl)adenine Is Embryotoxic in Transgenic Mice

1991 • 11 citations

Anti-HIV Activity of the Antisense Oligonucleotides Bearing Lipophilic and Alkylating Groups at the 5′-Terminus

1991 • 9 citations

Retroviral vectors as vaccines and immunotherapeutics.

1990 • 7 citations

Pentoxifylline in treatment of acquired immunodeficiency syndrome? [letter; comment]

1992 • 7 citations

Arrest of cell cycle progression of HeLa cells in the early G1 phase in K⁺‐depleted conditions and its recovery upon addition of insulin and LDL

1993 • 4 citations