HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

1990 • 1,288 citations

DNA Amplification for Direct Detection of HIV-1 in DNA of Peripheral Blood Mononuclear Cells

1988 • 979 citations

Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

1991 • 851 citations

High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection

1991 • 697 citations

Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.

1989 • 544 citations

Lymphoid organs function as major reservoirs for human immunodeficiency virus.

1991 • 489 citations

Biological and biochemical characterization of a cloned Leu-3- cell surviving infection with the acquired immune deficiency syndrome retrovirus.

1986 • 413 citations

AIDS: Etiology, Diagnosis, Treatment, and Prevention.

1985 • 407 citations

Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer cleavage detection

1987 • 358 citations

Lymphoid Germinal Centers Are Reservoirs of Human Immunodeficiency Virus Type 1 RNA

1991 • 301 citations

Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection

1991 • 273 citations

Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes.

1990 • 237 citations

Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells.

1992 • 231 citations

Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease

1992 • 166 citations

Primary HIV infection

1991 • 145 citations

Spectrum of Morphologic Changes of Lymph Nodes from Patients with AIDS or AIDS-Related Complexes

1986 • 141 citations

Frequent Detection of HIV-1-Specific mRNAs in Infected Individuals Suggests Ongoing Active Viral Expression in All Stages of Disease

1991 • 104 citations

AIDS — Etiology, Diagnosis, Treatment and Prevention

1989 • 24 citations