Rational Design of Peptide-Based HIV Proteinase Inhibitors

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Characterization of EBV‐genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non‐Hodgkin lymphoma

1977 • 698 citations

A structural model for the retroviral proteases

1987 • 594 citations

Renin inhibitors. Synthesis of transition-state analog inhibitors containing phosphorus acid derivatives at the scissile bond

1989 • 467 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

HTLV-III gag Protein Is Processed in Yeast Cells by the Virus pol -Protease

1986 • 289 citations

Potent new inhibitors of human renin

1982 • 239 citations

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

1990 • 234 citations

Novel renin inhibitors containing the amino acid statine

1983 • 176 citations

Effective blocking of HIV‐1 proteinase activity by characteristic inhibitors of aspartic proteinases

1989 • 166 citations

Peptide substrates and inhibitors of the HIV-1 protease

1989 • 162 citations

An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity.

1988 • 137 citations

Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation.

1988 • 127 citations

Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

1990 • 127 citations

Human Retroviruses, Cancer, and AIDS. Approaches to Prevention and Therapy

1988 • 53 citations

Comparison of the Human Immunodeficiency Virus Type 1 and 2 Proteases by Hybrid Gene Construction and trans-Complementation

1989 • 48 citations

Human renin: A new class of inhibitors

1986 • 36 citations

Comparison of antigen capture assays against HIV-1 in evaluating antiviral compounds

1989 • 30 citations

Inhibition of the aspartic proteinase from HIV‐2

1989 • 28 citations