In vitro inhibition of human immunodeficiency virus (HIV) type 1 replication by C2 symmetry-based HIV protease inhibitors as single agents or in combinations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

1985 • 1,830 citations

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

1986 • 1,032 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

ADMINISTRATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE, AN INHIBITOR OF HTLV-III/LAV REPLICATION, TO PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1986 • 806 citations

Molecular Targets for AIDS Therapy

1990 • 736 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

PHASE I STUDIES OF 2',3'-DIDEOXYCYTIDINE IN SEVERE HUMAN IMMUNODEFICIENCY VIRUS INFECTION AS A SINGLE AGENT AND ALTERNATING WITH ZIDOVUDINE (AZT)

1988 • 513 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

In Vivo Activity Against HIV and Favorable Toxicity Profile of 2′,3′-Dideoxyinosine

1989 • 426 citations

2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 391 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

A Randomized Controlled Trial of a Reduced Daily Dose of Zidovudine in Patients with the Acquired Immunodeficiency Syndrome

1990 • 330 citations

HTLV-III gag Protein Is Processed in Yeast Cells by the Virus pol -Protease

1986 • 289 citations

Once-Daily Administration of 2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 253 citations

Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues

1990 • 234 citations

Structure-based, C2 symmetric inhibitors of HIV protease

1990 • 213 citations

Circulating p24 Antigen Levels and Responses to Dideoxycytidine in Human Immunodeficiency Virus (HIV) Infections

1989 • 211 citations

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

1990 • 186 citations

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1989 • 181 citations

Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease

1991 • 133 citations

L-687,908, a potent hydroxyethylene containing HIV protease inhibitor

1991 • 126 citations

Targeted therapy of human immunodeficiency virus‐related disease

1991 • 85 citations

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

1990 • 77 citations

Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro.

1990 • 57 citations

Virus Isolation and Identification

1988 • 33 citations

Synergistic Drug Combinations in AIDS Therapy

1990 • 31 citations

COMBO: A New Approach to the Analysis of Drug Combinations in Vitro^a

1990 • 16 citations

Strategies for the combination therapy of HIV infection.

1990 • 6 citations