Characterization of the double stranded RNA dependent RNase activity associated with recombinant reverse transcriptases

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A novel multigene family may encode odorant receptors: A molecular basis for odor recognition

1991 • 4,793 citations

Characterization of the AIDS-associated retrovirus reverse transcriptase and optimal conditions for its detection in virions

1985 • 449 citations

Rapid purification of homodimer and heterodimer HIV‐1 reverse transcriptase by metal chelate affinity chromatography

1990 • 333 citations

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1987 • 261 citations

Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants.

1988 • 228 citations

Retroviral reverse transcriptase: synthesis, structure, and function.

1990 • 212 citations

Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase.

1991 • 208 citations

Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.

1988 • 206 citations

RNase III cleavage of single-stranded RNA. Effect of ionic strength on the fideltiy of cleavage.

1976 • 165 citations

Point mutations in conserved amino acid residues within the C‐terminal domain of HIV‐1 reverse transcriptase specifically repress RNase H function

1989 • 165 citations

Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1

1992 • 147 citations

Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase.

1991 • 119 citations

Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain.

1989 • 117 citations

Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase

1990 • 81 citations

Effects of small insertions on the RNA-dependent DNA polymerase activity of HIV-1 reverse transcriptase

1989 • 48 citations

Double-stranded RNA-dependent RNase activity associated with human immunodeficiency virus type 1 reverse transcriptase.

1992 • 39 citations

Protein Expression and Purification

2001 • 33 citations

Characterization of the biochemical properties of recombinant ribonuclease III

1990 • 29 citations