Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

1991 • 686 citations

Ordered Appearance of Zidovudine Resistance Mutations during Treatment of 18 Human Immunodeficiency Virus-Positive Subjects

1992 • 369 citations

Restricted expression of human T-Cell leukemia-lymphoma virus (HTLV) in Transformed human umbilical cord blood lymphocytes

1983 • 332 citations

Development of a sensitive quantitative focal assay for human immunodeficiency virus infectivity

1988 • 314 citations

Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes

1991 • 278 citations

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1990 • 208 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1989 • 181 citations

Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1990 • 180 citations

Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity.

1989 • 162 citations

AIDS virus reverse transcriptase defined by high level expression in Escherichia coli.

1987 • 126 citations

Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells

1990 • 109 citations

Decreased In Vitro Susceptibility to Zidovudine of HIV Isolates Obtained from Patients with AIDS

1990 • 100 citations

Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.

1991 • 73 citations