Phosphorodithioate DNA as a Potential Therapeutic Drug

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide

1991 • 3,211 citations

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1992 • 2,361 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

A new type of synthetic peptide library for identifying ligand-binding activity

1991 • 1,769 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Antisense oligonucleotides: a new therapeutic principle

1990 • 1,616 citations

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

1991 • 1,319 citations

Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells

1986 • 1,260 citations

Nucleotide sequence of the AIDS virus, LAV

1985 • 1,225 citations

Cloning and expression of the human erythropoietin gene.

1985 • 1,144 citations

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

Expression in Escherichia coli of chemically synthesized genes for human insulin.

1979 • 813 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

Molecular Targets for AIDS Therapy

1990 • 736 citations

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

1992 • 688 citations

A detailed model of reverse transcription and tests of crucial aspects

1979 • 621 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

1991 • 551 citations

ICOSAHEDRAL RNA VIRUS STRUCTURE

1989 • 532 citations

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

1979 • 517 citations

Retroviruses

1988 • 512 citations

Oligodeoxynucleotides as inhibitors of gene expression: a review.

1988 • 419 citations

Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties

1990 • 400 citations

Cloning and expression of the hyman erythropoietin gene

1985 • 353 citations

[15] Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method

1987 • 324 citations

HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.

1989 • 301 citations

Modulation of eukaryotic gene expression by complementary RNA or DNA sequences.

1988 • 227 citations

Synthetic lacoperator DNA is functional in vivo

1976 • 196 citations

Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide

1989 • 190 citations

Chemically Modified Oligonucleotides as Probes and Inhibitors

1991 • 143 citations

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates)

1991 • 142 citations

Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications.

1991 • 140 citations

Antisense oligonucleotides as antiviral agents

1992 • 138 citations

Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids

1990 • 127 citations

Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?

1991 • 108 citations

Synthesis and properties of dithymidine phosphate analogues containing 3′-thiothymidine

1990 • 102 citations

The rapid identification of HIV protease inhibitors through the synthesis and screening of defined peptide mixtures

1991 • 97 citations

Synthesis and characterization of dinucleoside phosphorodithioates

1988 • 88 citations

Cloned synthetic lac operator DNA is biologically active

1976 • 79 citations

Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells

1989 • 79 citations

Synthesis and properties of oligonucleotides containing aminodeoxythymidine units

1992 • 75 citations

Octa(thymidine methanephosphonates) of partially defined stereochemistry: synthesis and effect of chirality at phosphorus on binding to pentadecadeoxyriboadenylic acid

1990 • 71 citations

A potential role for antisense oligonucleotide analogues in the development of oncogene targeted cancer chemotherapy.

1990 • 69 citations

A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).

1987 • 68 citations

Inhibition of human immunodeficiency virus activity by phosphorodithioate oligodeoxycytidine.

1992 • 62 citations

Cloning of chemically synthesized lactose operators

1977 • 44 citations

Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages

1989 • 44 citations

Inhibition of the p66/p51 form of human immunodeficiency virus reverse transcriptase by tRNA^Lys

1990 • 43 citations

Synthesis of deoxydinucleoside phosphorodithioates

1991 • 43 citations

Nucleoside phosphonodithioates as intermediates in the preparation of dinucleoside phosphorodithioates and phosphorothioates

1989 • 39 citations

Electrostatics and flexibility in protein-DNA interactions

1985 • 32 citations

Chemical and Biochemical Studies with Dithioate DNA

1991 • 24 citations

Synthesis of 5′-deoxy-5′-methylphosphonate linked thymidine oligonucleotides.

1993 • 22 citations

Preparation of Nucleoside Phosphorothioates, Phosphorodithioates and Related Compounds

1991 • 14 citations