c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.

1995 • 2,142 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

NF-κB Signals Induce the Expression of c-FLIP

2001 • 799 citations

Proteases for Cell Suicide: Functions and Regulation of Caspases

2000 • 720 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

2001 • 583 citations

Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex

2001 • 563 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

2001 • 550 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1998 • 531 citations

Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity

1998 • 522 citations

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

2001 • 521 citations

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

2000 • 509 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

1997 • 398 citations

Caspase-10 is an initiator caspase in death receptor signaling

2001 • 387 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

1997 • 339 citations

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein

1999 • 337 citations

CASH, a Novel Caspase Homologue with Death Effector Domains

1997 • 323 citations

Cell death attenuation by `Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

1998 • 318 citations

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

1997 • 316 citations

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

1998 • 269 citations

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX _L and initiates cell death

1997 • 238 citations

Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis

1999 • 229 citations

RETRACTED: Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes

1999 • 149 citations

TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity

2000 • 141 citations

The Death Receptors

1999 • 82 citations

Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes

2009 • 32 citations

Apoptosis: Biology and Mechanisms

1999 • 14 citations