Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Proteases to die for

1998 • 1,241 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons.

1998 • 486 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression.

1998 • 283 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression.

1999 • 273 citations

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

2000 • 239 citations

A Genetic Tool Used to Identify Thioredoxin as a Mediator of a Growth Inhibitory Signal

1991 • 189 citations

Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells.

1982 • 188 citations

Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

1997 • 152 citations

Antiproliferative Potencies of Interferons on Melanoma Cell Lines and Xenografts: Higher Efficacy of Interferon β

1992 • 144 citations

Interferon alfa receptor expression and growth inhibition by interferon alfa in human liver cancer cell lines

1999 • 139 citations

Specific immunoreactivity of hybridoma-secreted monoclonal anti-melanoma antibodies to cultured cells and freshly derived human cells.

1980 • 135 citations

Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.

1999 • 132 citations

p53-Independent Upregulation of KILLER/DR5 TRAIL Receptor Expression by Glucocorticoids and Interferon-γ

2001 • 129 citations

Alpha Interferon Suppresses the Cyclin D3 and cdc25A Genes, Leading to a Reversible G₀-Like Arrest

1996 • 124 citations

Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide.

1997 • 124 citations

Apo2 ligand/TNF-related apoptosis-inducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells.

2000 • 120 citations

Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines.

1997 • 120 citations

Growth Inhibitory Effects of Interferon-β but Not Interferon-α on Human Glioma Cells: Correlation of Receptor Binding, 2′,5′-O1igoadenylate Synthetase and Protein Kinase Activity

1990 • 63 citations

CD4 T cells kill melanoma cells by mechanisms that are independent of Fas (CD95)

1998 • 52 citations

Interferon-α Inhibits Cyclin E- and Cyclin D1-Dependent CDK-2 Kinase Activity Associated with RB Protein and E2F in Daudi Cells

1994 • 51 citations

Synergistic Antitumor Effects of a Combination of Interferon and Tamoxifen on Estrogen Receptor-Positive and Receptor-Negative Human Tumor Cell Lines In Vivo and In Vitro

1997 • 48 citations

Human myeloma cell apoptosis induced by interferon‐α

1998 • 48 citations

Antiproliferative Effects of Interferons on Human Melanoma Cells in the Human Tumor Colony-Forming Assay

1986 • 44 citations

Recombinant IFN-alpha (2b) increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells.

1999 • 43 citations

A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes

1998 • 36 citations

Induction of Apoptosis in Cultured Colon Cancer Cells by Transfection with Human Interferon β Gene

1999 • 18 citations

Effect of natural interferon-?? on the growth of melanoma cell lines

1998 • 17 citations

Induction of apoptotic cell death by IFNβ on HPV-16 transformed human keratinocytes

1999 • 9 citations