Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis.

Caspases: Enemies Within

1998 • 6,923 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

1998 • 1,781 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

Viruses and Interferons

2001 • 985 citations

Functional classification of interferon-stimulated genes identified using microarrays

2001 • 882 citations

PKR; a sentinel kinase for cellular stress

1999 • 823 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

Cell suicide for beginners

1998 • 686 citations

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

1995 • 574 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L

1997 • 552 citations

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

2002 • 525 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons.

1998 • 486 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor–related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of Type I IFNs

1999 • 477 citations

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

1978 • 435 citations

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

2001 • 434 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

DAP kinase links the control of apoptosis to metastasis

1997 • 394 citations

Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells

1977 • 367 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

1998 • 347 citations

RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases

2002 • 310 citations

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

2000 • 293 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration.

1998 • 270 citations

Antiviral response by natural killer cells throughTRAIL gene induction by IFN-α/β

2001 • 262 citations

A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System

1997 • 262 citations

2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

1995 • 259 citations

Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair

2000 • 256 citations

Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.

2001 • 245 citations

Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate Cancer

2002 • 235 citations

The acute promyelocytic leukaemia-associated PML gene is induced by interferon.

1995 • 228 citations

Mechanisms of Interferon-alpha induced apoptosis in malignant cells

2002 • 218 citations

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1

2002 • 216 citations

Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines

2000 • 213 citations

Activation of p38 Mitogen-Activated Protein Kinase and c-Jun NH₂-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways

2000 • 203 citations

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

2001 • 201 citations

Gene structure and function of the 2′-5′-oligoadenylate synthetase family

2000 • 199 citations

PKR, apoptosis and cancer

1999 • 193 citations

Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth

1978 • 184 citations

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

1999 • 183 citations

Possible role of galectin‐9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance

2002 • 183 citations

The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis

1998 • 178 citations

Identification of X-linked Inhibitor of Apoptosis-associated Factor-1 as an Interferon-stimulated Gene That Augments TRAIL Apo2L-induced Apoptosis

2002 • 176 citations

Modular Structure of PACT: Distinct Domains for Binding and Activating PKR

2001 • 174 citations

The Involvement of TNF-α-Related Apoptosis-Inducing Ligand in the Enhanced Cytotoxicity of IFN-β-Stimulated Human Dendritic Cells to Tumor Cells

2001 • 161 citations

The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis

2000 • 159 citations

Inositol Hexakisphosphate Kinase 2 Mediates Growth Suppressive and Apoptotic Effects of Interferon-β in Ovarian Carcinoma Cells

2001 • 158 citations

Involvement of Fas-Mediated Apoptosis in the Inhibitory Effects of Interferon-α in Chronic Myelogenous Leukemia

1997 • 152 citations

Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells

1997 • 137 citations

IRF-1 Is an Essential Mediator in IFN-γ-Induced Cell Cycle Arrest and Apoptosis of Primary Cultured Hepatocytes

1999 • 136 citations

Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program.

2000 • 130 citations

A Novel Founder Mutation in the RNASEL Gene, 471delAAAG, Is Associated with Prostate Cancer in Ashkenazi Jews

2002 • 130 citations

Alpha Interferon Suppresses the Cyclin D3 and cdc25A Genes, Leading to a Reversible G₀-Like Arrest

1996 • 124 citations

Regression of basal cell carcinoma by intralesional interferon-alpha treatment is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide.

1997 • 124 citations

Analysis of the RNASEL Gene in Familial and Sporadic Prostate Cancer

2002 • 123 citations

Induction of apoptosis and inhibition of cell growth are independent responses to interferon-alpha in hematopoietic cell lines.

1997 • 120 citations

Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding Protein

1999 • 119 citations

Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines.

1982 • 115 citations

The Emerging Role of the Interferon-Induced PKR Protein Kinase as an Apoptotic Effector: A New Face of Death?

1999 • 108 citations

Molecular Cross-talk between the TRAIL and Interferon Signaling Pathways

2002 • 102 citations

Interferon alpha induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation.

1992 • 92 citations

Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.

2002 • 91 citations

Plasma Membrane Phospholipid Scramblase 1 Is Enriched in Lipid Rafts and Interacts with the Epidermal Growth Factor Receptor

2002 • 90 citations

Activation or suppression of the tumoricidal properties of monocytes from cancer patients following treatment with human recombinant gamma-interferon.

1986 • 86 citations

Caspase-Dependent Apoptosis by 2′,5′-Oligoadenylate Activation of RNase L Is Enhanced by IFN-β

2000 • 83 citations

Transcriptional control of the human plasma membranephospholipid scramblase 1 gene is mediated by interferon-α

2000 • 81 citations

A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family

2001 • 80 citations

IFN-β Pretreatment Sensitizes Human Melanoma Cells to TRAIL/Apo2 Ligand-Induced Apoptosis

2002 • 78 citations

IFN‐γupregulates apoptosis‐related molecules and enhances Fas‐mediated apoptosis in human cholangiocarcinoma

2002 • 76 citations

Regulatable Expression of the Interferon-Induced Double-Stranded RNA Dependent Protein Kinase PKR Induces Apoptosis and Fas Receptor Expression

1999 • 75 citations

Fas/APO-1 (CD95)–Mediated Apoptosis Is Activated by Interferon-γ and Interferon- in Interleukin-6 (IL-6)–Dependent and IL-6–Independent Multiple Myeloma Cell Lines

1998 • 75 citations

Impact of RNase L Overexpression on Viral and Cellular Growth and Death

1998 • 74 citations

Interferons as antiangiogenic agents

2002 • 73 citations

Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics

2002 • 67 citations

Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line

1998 • 65 citations

The role of caspase-8 in resistance to cancer chemotherapy

2001 • 65 citations

c-Abl Tyrosine Kinase Binds and Phosphorylates Phospholipid Scramblase 1

2001 • 64 citations

Association of Galectin-9 with Eosinophil Apoptosis

2002 • 63 citations

Heterogenous susceptibility to CD95-induced apoptosis in melanoma cells correlates with bcl-2 and bcl-x expression and is sensitive to modulation by interferon-?

1999 • 62 citations

Stoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L

1996 • 62 citations

Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.

2002 • 61 citations

Interferon and Malignant Disease - How Does it Work and Why Doesn't it Always?

1998 • 61 citations

Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-γ in human breast tumour cells

2002 • 59 citations

Human myeloma cell apoptosis induced by interferon‐α

1998 • 48 citations

Impaired alpha-interferon signaling in transitional cell carcinoma: lack of p48 expression in 5637 cells.

2001 • 42 citations

Monitoring Activation of Ribonuclease L by 2′, 5′-Oligoadenylates Using Purified Recombinant Enzyme and Intact Malignant Glioma Cells

2001 • 18 citations

Analysis and origins of the human and mouse RNase L genes: mediators of interferon action

2000 • 16 citations