TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

2000 • 847 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

1999 • 557 citations

Multiple signals converging on NF-κB

1999 • 483 citations

TRAIL: a molecule with multiple receptors and control mechanisms

1998 • 459 citations

Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma.

1999 • 394 citations

Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

2000 • 391 citations

Multiple Myeloma

1997 • 389 citations

Molecular determinants of response to TRAIL in killing of normal and cancer cells.

2000 • 379 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells

1997 • 278 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL

2000 • 259 citations

Functional Analysis of TRAIL Receptors Using Monoclonal Antibodies

1999 • 241 citations

A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells.

1996 • 229 citations

The Death Domain Kinase RIP Is Essential for TRAIL (Apo2L)-Induced Activation of IκB Kinase and c-Jun N-Terminal Kinase

2000 • 225 citations

Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells

2000 • 213 citations

Role of NF-κB in the Rescue of Multiple Myeloma Cells From Glucocorticoid-Induced Apoptosis by Bcl-2

1999 • 202 citations

APO2 ligand: a novel lethal weapon against malignant glioma?

1998 • 193 citations

SHP2 Mediates the Protective Effect of Interleukin-6 against Dexamethasone-induced Apoptosis in Multiple Myeloma Cells

2000 • 189 citations

Caffeic Acid Phenethyl Ester Induces Leukocyte Apoptosis, Modulates Nuclear Factor-Kappa B and Suppresses Acute Inflammation

2000 • 164 citations

Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers.

1999 • 162 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells

1999 • 158 citations

TRAIL/Apo2L Activates c-Jun NH2-terminal Kinase (JNK) via Caspase-dependent and Caspase-independent Pathways

1998 • 144 citations

Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: the trail to non-toxic cancer therapeutics (review).

1999 • 137 citations

Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5.

2001 • 131 citations

Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone

1999 • 129 citations

Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand.

2000 • 95 citations

Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells.

2000 • 89 citations

Interleukin-6 in multiple myeloma and related plasma cell dyscrasias

1998 • 84 citations

Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase

1998 • 84 citations

PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes

1997 • 83 citations

Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma

2000 • 83 citations

APOPTOSIS-INDUCED BY TRAIL AND TNF-α IN HUMAN MULTIPLE MYELOMA CELLS IS NOT BLOCKED BY BCL-2

1999 • 61 citations

Anti-Estrogens Induce Apoptosis of Multiple Myeloma Cells

1998 • 57 citations

Sensitization of AIDS-Kaposi’s Sarcoma Cells to Apo-2 Ligand-Induced Apoptosis by Actinomycin D

1999 • 53 citations

Functional expression of TRAIL by lymphoid and myeloid tumour cells

1999 • 43 citations

Bone marrow transplantation in multiple myeloma

1999 • 13 citations

[Growth characteristics of a human myeloma cell line transfected with IL-6 cDNA].

1993 • 1 citations