Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

A New Method for the Cytofluorometric Analysis of Mitochondrial Membrane Potential Using the J-Aggregate Forming Lipophilic Cation 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine Iodide (JC-1)

1993 • 1,015 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

The Role of c-FLIP in Modulation of CD95-induced Apoptosis

1999 • 823 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

A Selective Procedure for DNA Extraction from Apoptotic Cells Applicable for Gel Electrophoresis and Flow Cytometry

1994 • 670 citations

[29] Mitochondrial membrane potential monitored by JC-1 dye

1995 • 668 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

TRAIL: a molecule with multiple receptors and control mechanisms

1998 • 459 citations

Rhabdomyosarcoma: An Overview

1999 • 367 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

1999 • 313 citations

TRAIL/Apo-2-ligand-induced apoptosis in human T cells

1998 • 273 citations

Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling

1997 • 256 citations

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

1996 • 251 citations

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells.

1998 • 244 citations

APO2 ligand: a novel lethal weapon against malignant glioma?

1998 • 193 citations

Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells

1998 • 129 citations

A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells.

1999 • 98 citations

RHABDOMYOSARCOMA

1997 • 89 citations

Molecular Cloning and Characterization of Two Novel Pro-apoptotic Isoforms of Caspase-10

1999 • 85 citations

Expression ofTRAILand Its Receptors in Human Brain Tumors

1999 • 82 citations

Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.

1987 • 82 citations

Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7.

1998 • 73 citations

Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis.

1999 • 67 citations

p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells

1999 • 61 citations

Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing

1998 • 58 citations

Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells

1999 • 58 citations

Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.

1998 • 47 citations

Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma.

1998 • 46 citations

Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells

1998 • 38 citations

Fas (APO-1/CD95) signaling pathway is intact in radioresistant human glioma cells.

1999 • 35 citations

Detection of drug-induced apoptosis by flow cytometry after alkaline extraction of ethanol fixed cells

1996 • 24 citations