Pro-survival Function of Akt/Protein Kinase B in Prostate Cancer Cells

Mitochondria and Apoptosis

1998 • 8,909 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Cancer statistics, 1999

1999 • 3,154 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

Mitochondrial control of cell death

2000 • 3,098 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

1998 • 1,101 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

2000 • 968 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

FADD/MORT1 and Caspase-8 Are Recruited to TRAIL Receptors 1 and 2 and Are Essential for Apoptosis Mediated by TRAIL Receptor 2

2000 • 792 citations

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

1996 • 785 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

2000 • 651 citations

Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria

1999 • 642 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Removal of endotoxin from protein solutions by phase separation using triton X-114

1990 • 584 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

1999 • 557 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons

1999 • 537 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

Akt Protein Kinase Enhances Human Telomerase Activity through Phosphorylation of Telomerase Reverse Transcriptase Subunit

1999 • 479 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL

1999 • 470 citations

TRAIL: a molecule with multiple receptors and control mechanisms

1998 • 459 citations

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

1999 • 440 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

1998 • 388 citations

Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways

2001 • 387 citations

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

1997 • 383 citations

Molecular determinants of response to TRAIL in killing of normal and cancer cells.

2000 • 379 citations

Removal of Endotoxin from Recombinant Protein Preparations

1997 • 321 citations

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

1999 • 289 citations

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1999 • 279 citations

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN.

1999 • 275 citations

Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

2000 • 274 citations

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1998 • 265 citations

Akt-Dependent and -Independent Survival Signaling Pathways Utilized by Insulin-Like Growth Factor I

1998 • 248 citations

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

1999 • 216 citations

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

2001 • 196 citations

The Bile Acid Taurochenodeoxycholate Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2000 • 188 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)

2000 • 183 citations

Bcl-2 and Bcl-X_L Block Thapsigargin-Induced Nitric Oxide Generation, c-Jun NH₂-Terminal Kinase Activity, and Apoptosis

1999 • 151 citations

Bcl-2–Mediated Drug Resistance

1999 • 147 citations

Effect of Phosphoinositide-Dependent Kinase 1 on Protein Kinase B Translocation and Its Subsequent Activation

2000 • 137 citations

PTEN/MMAC1/TEP1 involvement in primary prostate cancers

1998 • 134 citations

Overexpression of Bcl2 Blocks TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Human Lung Cancer Cells

2001 • 133 citations

The Point of No Return: Mitochondria, Caspases, and the Commitment to Cell Death

1998 • 130 citations

Activity of TNF‐related apoptosis‐inducing ligand (TRAIL) in haematological malignancies

1997 • 124 citations

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1998 • 111 citations

Failure of Bcl‐2 to block cytochrome c redistribution during TRAIL‐induced apoptosis

2000 • 109 citations

Chemotherapy for advanced hormone refractory prostate cancer

1999 • 109 citations

Signalling by proteolysis: death receptors induce apoptosis

1998 • 80 citations

The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis

1998 • 69 citations

Intracellular Mechanisms of TRAIL and Its Role in Cancer Therapy

2000 • 66 citations

Chromosome 10 alterations in prostate adenocarcinoma (review).

1998 • 61 citations

Death and Survival Signals Determine Active/Inactive Conformations of Pro-apoptotic BAX, BAD, and BID Molecules

1999 • 58 citations

Human astrocytic brain tumors express APO2L/TRAIL

1999 • 58 citations

Sensitization of AIDS-Kaposi’s Sarcoma Cells to Apo-2 Ligand-Induced Apoptosis by Actinomycin D

1999 • 53 citations

Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand.

2001 • 48 citations

Anti-androgens and other hormonal therapies for prostate cancer

1999 • 46 citations

The challenge of locally advanced prostate cancer.

1999 • 30 citations