Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.

1994 • 584 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

1996 • 520 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Absence of B7-dependent responses in CD28-deficient mice

1994 • 386 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Duration of TCR Stimulation Determines Costimulatory Requirement of T Cells

1996 • 372 citations

Targeting p53 as a general tumor antigen.

1995 • 315 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptidesin vivo

1996 • 308 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

MHC Class I–Restricted CTL Responses to Exogenous Antigens

1996 • 265 citations

Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes

1997 • 264 citations

Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines.

1996 • 262 citations

Peripheral T Cell Tolerance

1992 • 223 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice.

1994 • 194 citations

Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide

1996 • 155 citations

Tumor antigens recognized by T lymphocytes

1997 • 153 citations

In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein.

1994 • 150 citations

A Murine Renal Cell Carcinoma

1973 • 149 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

Cytotoxic T Cells Isolated from Ovarian Malignant Ascites Recognize a Peptide Derived from the HER-2/neu Proto-oncogene

1993 • 124 citations

p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge.

1996 • 123 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities. Low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection.

1992 • 107 citations

T cell responses are governed by avidity and co‐stimulatory thresholds

1996 • 107 citations

Identification of Her-2/Neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8

1997 • 107 citations

Influence of antigen dose and costimulation on the primary response of CD8+ T cells in vitro.

1996 • 87 citations

Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells.

1991 • 71 citations

Dose‐dependent T cell tolerance to an immunodominant self peptide

1994 • 57 citations

Escape of Thymocytes and Mature T Cells from Clonal Deletion Due to Limiting Tolerogen Expression Levels

1994 • 57 citations

A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice.

1990 • 41 citations

T cell tolerance and activation to a transgene‐encoded tumor antigen

1996 • 39 citations

Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance.

1993 • 35 citations

Tolerance is overcome in beef insulin‐transgenic mice by activation of low‐affinity autoreactive T cells

1996 • 32 citations

The antitumor immune response as a problem of self-nonself discrimination: Implications for immunotherapy

1993 • 26 citations

T cell responses are governed by avidity and costimulatory thresholds

1996 • 17 citations

Comparison of the T cell receptors on insulin-specific hybridomas from insulin transgenic and nontransgenic mice. Loss of a subpopulation of self-reactive clones.

1992 • 15 citations