On the front lines: intraepithelial lymphocytes as primary effectors of intestinal immunity

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

Recognition of a lipid antigen by CD1-restricted αβ+ T cells

1994 • 976 citations

Natural and synthetic non-peptide antigens recognized by human γδ T cells

1995 • 974 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

1994 • 651 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

Epithelial stem cells in vivo

1988 • 446 citations

The nature of major histocompatibility complex recognition by γδ T cells

1994 • 407 citations

Nonpeptide ligands for human gamma delta T cells.

1994 • 373 citations

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

1995 • 357 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

1990 • 281 citations

Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.

1991 • 268 citations

A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V_δ1 gene segment

1991 • 261 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Phenotypic complexity of intraepithelial lymphocytes of the small intestine.

1991 • 252 citations

Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.

1996 • 250 citations

Expression of Murine CD1 on Gastrointestinal Epithelium

1990 • 231 citations

Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium

1995 • 196 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.

1996 • 181 citations

Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine.

1995 • 171 citations

Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine.

1993 • 164 citations

MHC class II expression by the gut epithelium

1988 • 164 citations

Lymphocytes isolated from the intestinal lamina propria of normal nonhuman primates have increased expression of genes associated with T-cell activation

1988 • 163 citations

TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1.

1995 • 161 citations

Expression of the thymus leukemia antigen in mouse intestinal epithelium.

1990 • 161 citations

Differential function of intestinal intraepithelial lymphocyte subsets.

1992 • 160 citations

Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine.

1996 • 151 citations

Extrathymic intestinal T-cell development: virtual reality?

1995 • 149 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules

1990 • 145 citations

Evidence that CD4⁺, but not CD8⁺ T cells are responsible for murine interleukin‐2‐deficient colitis

1995 • 144 citations

Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.

1996 • 143 citations

Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies.

1995 • 132 citations

Inefficient positive selection of T cells directed by haematopoietic cells

1992 • 132 citations

Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.

1994 • 123 citations

Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.

1993 • 119 citations

Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice

1995 • 118 citations

Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: Implications for differentiation of cells bearing a CD3‐associated γδ T cell receptor

1990 • 116 citations

Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection

1989 • 114 citations

Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent.

1993 • 98 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

T-Cell Antigen Receptors

1990 • 85 citations

Differential regulation of B7 mRNA in enterocytes and lymphoid cells.

1993 • 84 citations

Thymus-Neuroendocrine Interactions in Extrathymic T Cell Development

1994 • 83 citations

Regional Specialization of Intraepithelial T Cells in the Murine Small and Large Intestine

1995 • 79 citations

T Lymphocytes in Human Gut Epithelium Preferentially Express the α/β Antigen Receptor and are often CD45/UCHL1‐Positive

1989 • 78 citations

Thymic origin of embryonic intestinal gamma/delta T cells.

1993 • 74 citations

Human intestinal epithelial cell-induced CD8+ T cell activation is mediated through CD8 and the activation of CD8-associated p56lck.

1995 • 73 citations

Developmental relationship between cytotoxic α/β T cell receptor‐positive intraepithelial lymphocytes and Peyer's patch lymphocytes

1993 • 72 citations

A novel pathway of thymus-directed T lymphocyte maturation.

1994 • 69 citations

Intraepithelial lymphocytes contain virus-specific, MHC-restricted cytotoxic cell precursors after gut mucosal immunization with reovirus serotype 1/Lang.

1989 • 64 citations

Adhesion molecules intercellular adhesion molecule-1 (ICAM-1), ICAM-3 and B7 are not expressed by epithelium in normal or inflamed colon

1995 • 62 citations

T cells in inductive and effector compartments of the intestinal mucosal immune system of nonhuman primates differ in lymphokine mRNA expression, lymphokine utilization, and regulatory function.

1990 • 61 citations

Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo

1994 • 61 citations

β2 Integrins and ICAM-1 Are Involved in Establishment of the Intestinal Mucosal T Cell Compartment

1996 • 57 citations

T cell receptor-triggered activation of intraepithelial lymphocytes in vitro

1993 • 57 citations

Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser.

1991 • 54 citations

Differential peripheral expansion and in vivo antigen reactivity of α/β and γ/δ T cells emigrating from the early fetal lamb thymus

1990 • 50 citations

Diversity, Development, Ligands, and Probable Functions of T Cells

1989 • 47 citations

Disparate CD4+ Lamina Propria (LP) Lymphokine Secretion Profiles in Inflammatory Bowel Disease

1997 • 45 citations

Human intestinal intraepithelial lymphocytes have potent chemotactic activity

1995 • 42 citations

Heterogeneity and biased T cell receptor alpha/beta repertoire of mucosal CD8+ cells from murine large intestine: implications for functional state.

1994 • 42 citations

Cellular immunity and the immunotherapy of cancer

1990 • 38 citations

Influence of beta 2-microglobulin expression on gamma interferon secretion and target cell lysis by intraepithelial lymphocytes during intestinal Listeria monocytogenes infection

1996 • 35 citations

Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: Signaling of high density αβ T cell receptor⁺ and γδ T cell receptor⁺ T cells via T cell receptor‐CD3 complex results in interferon‐γ and interleukin‐5 production, while low density T cells undergo DNA fragmentation

1994 • 35 citations

Innate Humoral Factors

1994 • 35 citations

Diversity, Development, Ligands and Probable Functions of γδ T Cells

1989 • 31 citations

Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes.

1995 • 15 citations

T-Cell development and selection in the intestinal epithelium

1995 • 14 citations

Mucosal Barrier

1994 • 13 citations

The Role of the Mucosal Immune System in Ulcerative Colitis and Crohn's Disease

1994 • 11 citations

Development of Intestinal Intraepithelial Lymphocytes

1996 • 8 citations

Relationship between alpha/beta T cell receptor/CD8+ precursors for cytotoxic T lymphocytes in the murine peyer's patches and the intraepithelial compartment probed by oral infection with reovirus

1991 • 7 citations

The Role of Endogenous Luminal Bacteria and Bacterial Products in the Pathogenesis of Experimental Enterocolitis and Systemic Inflammation

1996 • 3 citations