Structural Features of Peptide Analogs of Human Histocompatibility Leukocyte Antigen Class I Epitopes That Are More Potent and Immunogenic than Wild-Type Peptide

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Proteins: Structures and molecular properties

1985 • 697 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

1987 • 637 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Protein volume in solution

1972 • 591 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.

1996 • 416 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

Targeting p53 as a general tumor antigen.

1995 • 315 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

Amino Acid, Peptide, and Protein Volume in Solution

1984 • 280 citations

Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes

1997 • 264 citations

The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial Tumors

1998 • 235 citations

Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

1994 • 233 citations

Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

1997 • 210 citations

LIGAND RECOGNITION BY T CELL RECEPTORS

1998 • 207 citations

Heteroclitic Immunization Induces Tumor Immunity

1998 • 203 citations

Different roles for rcytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

1996 • 171 citations

Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes

1999 • 166 citations

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding.

1997 • 163 citations

Evaluation of CD8+ T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide

2000 • 107 citations

Exploring immunological specificity using synthetic peptide combinatorial libraries

1999 • 101 citations

A superagonist variant of peptide MART1/Melan A27-35 elicits anti-melanoma CD8+ T cells with enhanced functional characteristics: implication for more effective immunotherapy.

1999 • 97 citations

Analogues of CTL epitopes with improved MHC class-I binding capacity elicit anti-melanoma CTL recognizing the wild-type epitope

1997 • 94 citations

TCR-Independent Pathways Mediate the Effects of Antigen Dose and Altered Peptide Ligands on Th Cell Polarization

1999 • 83 citations

Agonist peptide from a cytotoxic t-lymphocyte epitope of human carcinoembryonic antigen stimulates production of tc1-type cytokines and increases tyrosine phosphorylation more efficiently than cognate peptide

2000 • 78 citations

Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.

1997 • 71 citations

Peptides derived from self-proteins as partial agonists and antagonists of human CD8+ T-cell clones reactive to melanoma/melanocyte epitope MART1(27-35).

1998 • 71 citations

Assessment of Immunogenicity of Human Melan-A Peptide Analogues in HLA-A*0201/Kb Transgenic Mice

1999 • 65 citations

Identification of HLA-A*0201-restricted CTL epitopes encoded by the tumor-specificMAGE-2 gene product

1997 • 60 citations

Use of combinatorial peptide libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes.

1996 • 59 citations

Hepatitis C Virus Envelope Glycoprotein E1 Originates in the Endoplasmic Reticulum and Requires Cytoplasmic Processing for Presentation by Class I MHC Molecules

1999 • 58 citations

Major histocompatibility complex class I allele‐specific peptide libraries: Identification of peptides that mimic an H‐Y T cell epitope

1994 • 49 citations

The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope

1999 • 42 citations

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

2000 • 41 citations

Termination of Peripheral Tolerance to a T Cell Epitope by Heteroclitic Antigen Analogues

1998 • 38 citations

Characterization of an in situ IFN-γ ELISA assay which is able to detect specific peptide responses from freshly isolated splenocytes induced by DNA minigene immunization

2000 • 26 citations