Glutathione Conjugation of Bay- and Fjord-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Glutathione Transferases M1-1 and P1-1

Bioactivation of foreign compounds

1985 • 733 citations

Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes

1993 • 449 citations

Polycyclic Hydrocarbons and Carcinogenesis

1985 • 403 citations

Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

1992 • 277 citations

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

1995 • 180 citations

Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene.

1986 • 170 citations

Advances in Drug Metabolism in Man

1995 • 167 citations

Glutathione transferases in rat lung: the presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+)-7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene

1986 • 118 citations

Structure and Function of the Xenobiotic Substrate Binding Site of a Glutathione S-Transferase as Revealed by X-ray Crystallographic Analysis of Product Complexes with the Diastereomers of 9-(S-Glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene

1994 • 111 citations

Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a, l]pyrene (dibenzo[def, p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene

1995 • 90 citations

Biological Reactive Intermediates IV

1991 • 84 citations

Polycyclic aromatic hydrocarbons: Chemistry and carcinogenicity

1992 • 70 citations

Glutathione conjugation of the carcinogenic and mutagenic electrophile (±)-7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetra hydrobenzo[a]pyrene catalyzed by purified rat liver glutathione transferases

1985 • 68 citations

Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line

1992 • 60 citations

Synthesis and tumor-initiating activity in mouse skin of dibenzo[a,l]pyrene syn- and anti-fjord-region diolepoxides

1994 • 57 citations

Glutathione conjugation and DNA-binding of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and (±)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in isolated rat hepatocytes

1982 • 50 citations

Glutathione S-Transferases: Structure, Function and Clinical Implications

2007 • 46 citations