THE PHARMACOLOGY AND TOXICOLOGY OF POLYPHENOLIC-GLUTATHIONE CONJUGATES

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli

1984 • 1,608 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Oxidants as Stimulators of Signal Transduction

1997 • 1,380 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Naturally Occurring Quinones

1971 • 1,283 citations

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

1979 • 1,228 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation

1990 • 869 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells

1977 • 787 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Quinone chemistry and toxicity

1992 • 732 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

The ATP-dependent glutathione S-conjugate export pump

1992 • 656 citations

REGULATION AND EXPRESSION OF THE ADAPTIVE RESPONSE TO ALKYLATING AGENTS

1988 • 645 citations

Hematopoietic growth factors.

1987 • 621 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

INDUCIBLE DNA REPAIR SYSTEMS

1985 • 586 citations

Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

1977 • 573 citations

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1996 • 544 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Hematopoietic Growth Factors

1989 • 465 citations

Sampling of vehicle emissions for chemical analysis and biological testing.

1983 • 457 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

The Identification of Polynuclear Aromatic Hydrocarbon (PAH) Derivatives in Mutagenic Fractions of Diesel Particulate Extracts

1981 • 404 citations

Control of Messenger RNA Stability

1993 • 394 citations

Mutagenicity of quinones: pathways of metabolic activation and detoxification.

1984 • 384 citations

Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals

1985 • 371 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Reversible histone modification and the chromosome cell cycle

1992 • 357 citations

Ribonucleotide reductase: regulation, regulation, regulation

1992 • 305 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

The search for a solution to senile cataracts. Proctor lecture.

1984 • 268 citations

Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations.

1992 • 262 citations

Redox signalling and the control of cell growth and death

1995 • 256 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

The Mammalian Choroid Plexus

1989 • 232 citations

Hypoxic induction of the human erythropoietin gene: cooperation between the promoter and enhancer, each of which contains steroid receptor response elements.

1992 • 211 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1

1991 • 192 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

1993 • 179 citations

Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression

1987 • 179 citations

Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage.

1992 • 175 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

1988 • 165 citations

Characterization of specific binding sites for [3H]-staurosporine on various protein kinases

1990 • 164 citations

Evidence for carrier-mediated transport of glutathione across the blood-brain barrier in the rat.

1990 • 163 citations

Amphetamine and its analogs : psychopharmacology, toxicology, and abuse

1994 • 143 citations

Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells.

1990 • 139 citations

Potential role of free radicals in benzene-induced myelotoxicity and leukemia

1991 • 139 citations

The Breast: Morphology, Physiology, and Lactation

1974 • 137 citations

Bcl2 inhibits apoptosis associated with terminal differentiation of HL- 60 myeloid leukemia cells

1994 • 136 citations

Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases

1992 • 134 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells.

1992 • 131 citations

Toxicology of Quinone-Thioethers

1992 • 130 citations

Histone Acetylation Influences both Gene Expression and Development of Xenopus laevis

1994 • 129 citations

Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

1991 • 129 citations

Glutathione conjugates of 2-bromohydroquinone are nephrotoxic.

1985 • 126 citations

Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.

1993 • 125 citations

Screening of Thiol Compounds: Depolarization‐Induced Release of Glutathione and Cysteine from Rat Brain Slices

1992 • 123 citations

Histones H2A/H2B inhibit the interaction of transcription factor IIIA with the Xenopus borealis somatic 5S RNA gene in a nucleosome.

1992 • 123 citations

Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA.

1990 • 120 citations

Transformed mammalian cells are deficient in kinase-mediated control of progression through the G1 phase of the cell cycle.

1991 • 119 citations

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

1996 • 118 citations

In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector

1988 • 118 citations

The blood‐brain barrier: Morphology, molecules, and neurothelin

1993 • 118 citations

Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice.

1990 • 117 citations

The continuous growth of vertebrate cells in the absence of sugar.

1981 • 114 citations

Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylation

1995 • 109 citations

Ca(2+)-dependent stimulation of retinoblastoma gene product phosphorylation and p34cdc2 kinase activation in serum-stimulated human fibroblasts.

1993 • 104 citations

Formation of glutathione-conjugated semiquinones by the reaction of quinones with glutathione: An ESR study

1987 • 98 citations

Interleukin-1: Biology, pathophysiology, and clinical prospects

1990 • 97 citations

Progressive maturation of chromatin structure regulates HSP70.1 gene expression in the preimplantation mouse embryo

1995 • 95 citations

Greater Number of Capillary Endothelial Cell Mitochondria in Brain Than in Muscle

1975 • 95 citations

Biological Reactivity of Polyphenolic−Glutathione Conjugates

1997 • 95 citations

2,5-bis-(Glutathion-S-yl)-α-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

1997 • 94 citations

Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons

1988 • 92 citations

The transferrin receptor.

1993 • 90 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation

1994 • 89 citations

Reduction of Brain Glutathione by <scp>l</scp>‐Buthionine Sulfoximine Potentiates the Dopamine‐Depleting Action of 6‐Hydroxydopamine in Rat Striatum

1989 • 86 citations

Ascorbate-quinone interactions: electrochemical, free radical, and cytotoxic properties.

1983 • 84 citations

Autogenous Regulation of Histone mRNA Decay by Histone Proteins in a Cell-Free System

1987 • 82 citations

Sampling of Vehicle Emissions for Chemical Analysis and Biological Testing

1983 • 81 citations

Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.

1990 • 81 citations

Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity

1993 • 81 citations

Metabolism of hydroquinone by human myeloperoxidase: Mechanisms of stimulation by other phenolic compounds

1991 • 79 citations

Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro.

1992 • 75 citations

Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.

1992 • 69 citations

Hematotox1city of inhaled benzene to Sprague‐Dawley rats and AKR mice at 300 ppm

1978 • 69 citations

Enzymic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

1992 • 67 citations

A survey on the electrochemical reduction of quinones

1970 • 66 citations

Possible reactions of 1,2-naphthaquinone in the eye.

1967 • 66 citations

Glutathione: New candidate neuropeptide in the central nervous system

1992 • 63 citations

Effects of Intracerebroventricular Administration of 5-(Glutathion-S-yl)-α-methyldopamine on Brain Dopamine, Serotonin, and Norepinephrine Concentrations in Male Sprague-Dawley Rats

1996 • 63 citations

2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants.

1988 • 63 citations

The transcription complex of the 5 S RNA gene, but not transcription factor IIIA alone, prevents nucleosomal repression of transcription.

1990 • 59 citations

Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy

1993 • 57 citations

Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems.

1992 • 56 citations

Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl]propane [(methylenedioxy)methamphetamine]

1992 • 56 citations

Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S- yl)hydroquinone

1997 • 53 citations

In vivo murine studies on the biochemical mechanism of naphthalene cataractogenesis

1989 • 52 citations

Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair

1996 • 51 citations

Glutathione conjugates of tert-butyl-hydroquinone, a metabolite of the urinary tract tumor promoter 3-tert-butyl-hydroxyanisole, are toxic to kidney and bladder.

1996 • 50 citations

Possible reactions of 1,2-naphthaquinone in the eye

1967 • 49 citations

Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione.

1992 • 49 citations

Altered growth factor expression during toxic proximal tubular necrosis and regeneration

1993 • 48 citations

Hydroxyl radical mediated demethylenation of (methylenedioxy)phenyl compounds

1991 • 47 citations

Metabolism of 5-(Glutathion-S-yl)-.alpha.-methyldopamine following Intracerebroventricular Administration to Male Sprague-Dawley Rats

1995 • 46 citations

Autogenous regulation of histone mRNA decay by histone proteins in a cell-free system.

1987 • 45 citations

Reactive Oxygen Species and DNA Damage in 2-Bromo-(glutathione-S-yl) hydroquinone-Mediated Cytotoxicity

1995 • 43 citations

Transformation of dopamine and .alpha.-methyldopamine by NG108-15 cells: formation of thiol adducts

1991 • 42 citations

Role of Growth Factors in Regulation of Renal Growth

1993 • 42 citations

Ah Locus: Genetic Differences in Susceptibility to Cataracts Induced by Acetaminophen

1978 • 42 citations

Cell growth inhibition by prostaglandin A2 results in elevated expression of gadd153 mRNA

1992 • 41 citations

Major metabolites of(±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons

1991 • 41 citations

Formation of catechol estrogen glutathione conjugates and gamma- glutamyl transpeptidase-dependent nephrotoxicity of 17beta-estradiol in the golden Syrian hamster

1997 • 41 citations

Definition of the Roles for Iron and Essential Fatty Acids in Cell Cycle Progression of Normal Human T Lymphocytes

1993 • 40 citations

Endogenous EGF as a potential renotrophic factor in ischemia-induced acute renal failure

1993 • 39 citations

Purification and some properties of peroxidases of rat bone marrow

1987 • 38 citations

Short term benzene exposure provides a growth advantage for granulopoietic progenitor cells over erythroid progenitor cells

1990 • 34 citations

Identification of Quinol Thioethers in Bone Marrow of Hydroquinone/Phenol-Treated Rats and Mice and Their Potential Role in Benzene-Mediated Hematotoxicity

1997 • 34 citations

Brain uptake of S-(1,2-dichlorovinyl)glutathione and , the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene

1993 • 34 citations

Characterization of a glutathione conjugate of the 1,4-benzosemiquinone-free radical formed in rat hepatocytes.

1988 • 33 citations

Neurotoxic effects of dichloroacetylene

1976 • 33 citations

Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites

1994 • 33 citations

Inhibition of DNA polymerase from L1210 murine leukemia by a sulfhydryl reagent from agaricus bisporus.

1977 • 33 citations

Metabolism of tert-Butylhydroquinone to S-Substituted Conjugates in the Male Fischer 344 Rat

1996 • 32 citations

p-Benzoquinone, a Reactive Metabolite of Benzene, Prevents the Processing of Pre-Interleukins-1a and -1b to Active Cytokines by Inhibition of the Processing Enzymes, Calpain, and Interleukin-1b Converting Enzyme

1996 • 32 citations

Toxicity, single-strand breaks, and 5-hydroxymethyl-2′-deoxyuridine formation in human breast epithelial cells treated with hydrogen peroxide

1993 • 32 citations

Genetic Differences in Cataract and Other Ocular Abnormalities Induced by Paracetamol and Naphthalene

1980 • 31 citations

Metabolism of methylenedioxyphenyl compounds by Rabbit liver preparations

1991 • 30 citations

Induction of mitochondrial metabolism and pH-modulated ammoniagenesis by rocking LLC-PK1 cells

1986 • 27 citations

Pharmacological studies on the in vivo cataractogenicity of acetaminophen in mice and rabbits*1

1988 • 27 citations

A morphological analysis of the short-term effects of benzene on the development of the hematological cells in the bone marrow of mice and the effects of interleukin-1α on the process

1995 • 27 citations

The Heat Shock Response in Xenopus Oocytes, Embryos, and Somatic Cells: A Regulatory Role for Chromatin

1995 • 27 citations

PGE₂-mediated cytoprotection in renal epithelial cells: evidence for a pharmacologically distinct receptor

1997 • 27 citations

3,4-Dihydroxybenzylamine: An Improved Dopamine Analog Cytotoxic for Melanoma Cells in Part Through Oxidation Products Inhibitory to DNA Polymerase

1983 • 26 citations

Pro-oxidant activation of ocular reductants. 2. Lens epithelial cell cytotoxicity of a dietary quinone is associated with a stable free radical formed with glutathione in vitro

1987 • 26 citations

Activation of the mouse cytokeratin A (endo A) gene in teratocarcinoma F9 cells by the histone deacetylase inhibitor Trichostatin A

1994 • 25 citations

Changes in deoxynucleoside triphosphate pools induced by inhibitors and modulators of ribonucleotide reductase

1985 • 25 citations

2-Hydroxy-4-glutathion-S-yl-17beta-estradiol and 2-hydroxy-1-glutathion- S-yl-17beta-estradiol produce oxidative stress and renal toxicity in an animal model of 17beta-estradiol-mediated nephrocarcinogenicity

1998 • 24 citations

Benzene and its metabolite, hydroquinone, induce granulocytic differentiation in myeloblasts by interacting with cellular signaling pathways activated by granulocyte colony‐stimulating factor

1995 • 24 citations

alpha-Methyldopamine, a key intermediate in the metabolic disposition of 3,4-methylenedioxyamphetamine in vivo in dog and monkey.

1978 • 23 citations

Butyrate Synchronization of Hepatocytes: Modulation of Cycling and Cell Cycle Regulated Gene Expression

1994 • 23 citations

Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones

1990 • 23 citations

Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells.

1996 • 23 citations

Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches

1992 • 22 citations

The Response of Renal Tubular Epithelial Cells to Physiologically and Chemically Induced Growth Arrest

1997 • 21 citations

Metabolic evidence for the involvement of enzymatic bioactivation in the cataractogenicity of acetaminophen in genetically susceptible (C57BL6) and resistant (DBA2) murine strains

1988 • 20 citations

Modulatory Role of Glutathione on μ‐Opioid, Substance P/Neurokinin‐1, and Kainic Acid Receptor Binding Sites

1992 • 19 citations

Individual purified core and linker histones induce histone H4 mRNA destabilization in vitro

1993 • 17 citations

The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: Possible role in cytotoxicity

1992 • 17 citations

Activation of DNA Synthesis and Expression of the JE Gene by Catalase in Mouse Osteoblastic Cells: Possible Involvement of Hydrogen Peroxide in Negative Growth Regulation

1995 • 17 citations

Inhibition of human glutathione S-transferases by dopamine, α-methyldopa and their 5-S-glutathionyl conjugates

1994 • 15 citations

Antitumor Effects of L-Glutamic Acid Dihydroxyanilides Against Experimental Melanoma

1980 • 15 citations

Early Morphological and Biochemical Changes During 2-Br-(diglutathion-S-yl)hydroquinone-Induced Nephrotoxicity

1994 • 14 citations

Thymidylate synthase as a target enzyme for the melanoma-specific toxicity of 4-S-cysteaminylphenol andN-acetyl-4-S-cysteaminylphenol

1992 • 14 citations

Inhibition of ribonucleotide reductase by antitumor agents related to levodopa and dopamine

1985 • 13 citations

DNA Damage,gadd153Expression, and Cytotoxicity in Plateau-Phase Renal Proximal Tubular Epithelial Cells Treated with a Quinol Thioether

1997 • 13 citations

Morphologic changes in kidneys of rats exposed to dichloroacetylene-ether

1971 • 12 citations

Apparent binding activity of [3H]glutathione in rat central and peripheral tissues

1988 • 12 citations

The Role of γ-Glutamyl Transpeptidase in Hydroquinone-Glutathione Conjugate Mediated Nephrotoxicity

1991 • 10 citations

Maitotoxin, a calcium channel activator, inhibits cell cycle progression through the G1/S and G2/M transitions and prevents CDC2 kinase activation in GH4C1 cells

1996 • 10 citations

Degradation of a Nonpolyadenylated Messenger: Histone mRNA Decay

1993 • 9 citations

Glutathione Conjugate-Mediated Toxicities

1994 • 9 citations

Cytopathologic Features Indicative of 5‐Hydroxytryptamine Axon Degeneration Are Observed in Rat Brain after Administration of d‐ and l‐Methylenedioxyamphetamine^a

1992 • 8 citations

Potent antinociceptive effects of centrally administered glutathione and glutathione-disulfide in mice

1992 • 7 citations

Inducible Gene Expression, Volume 1

1995 • 4 citations

Pharmacology of para-chloroamphetamine and analogs.

1976 • 3 citations

A survey on the electrochemical reduction of quinones

1970 • 2 citations

Deleted Work

1955 • 0 citations