GSTP1‐1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes

1993 • 449 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

X‐ray crystal structures of cytosolic glutathione S‐transferases

1994 • 430 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

1988 • 208 citations

Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

1995 • 180 citations

Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate

1990 • 160 citations

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1

1997 • 138 citations

Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate

1993 • 133 citations

Molecular Structure at 1·8 Å of Mouse Liver Class Pi Glutathione S-transferase Complexed with S-(p-Nitrobenzyl)glutathione and Other Inhibitors

1994 • 130 citations

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

1985 • 127 citations

The Three-Dimensional Structure of the Human Pi Class Glutathione Transferase P1-1 in Complex with the Inhibitor Ethacrynic Acid and Its Glutathione Conjugate^,

1997 • 121 citations

Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

1996 • 112 citations

Site-directed Mutagenesis of Human Glutathione Transferase P1-1

1995 • 98 citations

Stereoselective Conjugation of Prostaglandin A₂ and Prostaglandin J₂ with Glutathione, Catalyzed by the Human Glutathione S-Transferases A1-1, A2-2, M1a-1a, and P1-1

1997 • 88 citations

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1997 • 82 citations

Ethacrynic acid and its glutathione conjugate as inhibitors of glutathioneS-transferases

1993 • 81 citations

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

1996 • 73 citations

Inhibition of purified rat liver glutathione S-transferase isozymes by diuretic drugs

1985 • 57 citations

Enzymic reaction of chlorotrifluoroethene with glutathione: fluorine-19 NMR evidence for stereochemical control of the reaction

1985 • 46 citations

Investigation of the kinetic and stereochemical recognition of arene and azaarene oxides by isozymes A2 and C2 of glutathione S-transferase

1984 • 36 citations

Active-site tyrosyl residues are targets in the irreversible inhibition of a class Mu glutathione transferase by 2-(S-glutathionyl)-3,5,6-trichloro-1,4-benzoquinone.

1994 • 27 citations

Investigations of Glutathione Conjugation in Vitro by 1H NMR Spectroscopy. Uncatalyzed and Glutathione Transferase-Catalyzed Reactions

1995 • 16 citations

Acide éthacrynique

1978 • 10 citations