Glutathione and N-Acetylcysteine Conjugates of α-Methyldopamine Produce Serotonergic Neurotoxicity: Possible Role in Methylenedioxyamphetamine-Mediated Neurotoxicity

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

1988 • 548 citations

Anatomy of the Serotonergic System^a

1990 • 541 citations

3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites.

1987 • 455 citations

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

1987 • 451 citations

The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei

1987 • 407 citations

Hallucinogenic Amphetamine Selectively Destroys Brain Serotonin Nerve Terminals

1985 • 371 citations

The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain

1986 • 354 citations

Serotonergic Neuronal Systems

1987 • 341 citations

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1997 • 338 citations

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration

1988 • 255 citations

Dual serotoninergic projections to forebrain in the rat: Morphologically distinct 5‐HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives

1991 • 237 citations

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

1990 • 195 citations

Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat

1987 • 186 citations

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

1988 • 186 citations

Methylenedioxymethamphetamine-induced hyperthermia and neurotoxicity are independently mediated by 5-HT2 receptors

1990 • 134 citations

Human Class Mu Glutathione Transferases, in Particular Isoenzyme M2-2, Catalyze Detoxication of the Dopamine Metabolite Aminochrome

1997 • 127 citations

In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector

1988 • 118 citations

The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

1995 • 113 citations

Irreversible Inhibition of Mitochondrial Complex I by 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1): A Putative Nigral Endotoxin of Relevance to Parkinson's Disease

1997 • 111 citations

Serotoninergic innervation of the cat cerebral cortex

1988 • 101 citations

Biological Reactivity of Polyphenolic−Glutathione Conjugates

1997 • 95 citations

2,5-bis-(Glutathion-S-yl)-α-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations

1997 • 94 citations

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies.

1996 • 94 citations

Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons

1988 • 92 citations

Proximal Myotonic Myopathy with MRI White Matter Abnormalities of the Brain

1997 • 86 citations

Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine

1990 • 86 citations

Neurotoxicity of Endogenous Cysteinylcatechols

1997 • 84 citations

Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn‐superoxide dismutase transgenic mice

1995 • 83 citations

Increasing Use of “Ecstasy“ (MDMA) and other Hallucinogens on a College Campus

1994 • 82 citations

Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites

1989 • 82 citations

Oxidation of Dopamine in the Presence of Cysteine: Characterization of New Toxic Products

1997 • 82 citations

5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa.

1991 • 78 citations

Further Insights into the Influence of <scp>l</scp>-Cysteine on the Oxidation Chemistry of Dopamine: Reaction Pathways of Potential Relevance to Parkinson's Disease

1996 • 76 citations

Lack of serotonin neurotoxicity after intraraphe microinjection of (+)-3,4-methylenedioxymethamphetamine (MDMA)

1992 • 76 citations

Synthesis, Redox Properties,in VivoFormation, and Neurobehavioral Effects ofN-Acetylcysteinyl Conjugates of Dopamine: Possible Metabolites of Relevance to Parkinson's Disease

1996 • 65 citations

Effects of Intracerebroventricular Administration of 5-(Glutathion-S-yl)-α-methyldopamine on Brain Dopamine, Serotonin, and Norepinephrine Concentrations in Male Sprague-Dawley Rats

1996 • 63 citations

Symposium overview: the role of glutathione in neuroprotection and neurotoxicity

1999 • 62 citations

Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl]propane [(methylenedioxy)methamphetamine]

1992 • 56 citations

Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA.

1989 • 53 citations

Brain Mitochondria Catalyze the Oxidation of 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1) to Intermediates that Irreversibly Inhibit Complex I and Scavenge Glutathione: Potential Relevance to the Pathogenesis of Parkinson's Disease

1998 • 50 citations

Metabolism of 5-(Glutathion-S-yl)-.alpha.-methyldopamine following Intracerebroventricular Administration to Male Sprague-Dawley Rats

1995 • 46 citations

Transformation of dopamine and .alpha.-methyldopamine by NG108-15 cells: formation of thiol adducts

1991 • 42 citations

Major metabolites of(±)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons

1991 • 41 citations

The Properties of 3,4-Methylenedioxyamphetamine (MDA). I. A Review of the Literature

1973 • 35 citations

Chemistry and Pharmacology of Hallucinogens, Entactogens and Stimulants

1998 • 34 citations

Glutathione, γ-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohydroquinone oxidation

1990 • 33 citations

alpha-Methyldopamine, a key intermediate in the metabolic disposition of 3,4-methylenedioxyamphetamine in vivo in dog and monkey.

1978 • 23 citations

Artificial Cerebro-Spinal Fluid

1917 • 5 citations

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