Concise review of the glutathione S-transferases and their significance to toxicology

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1994 • 1,319 citations

Structure, Catalytic Mechanism, and Evolution of the Glutathione Transferases

1997 • 1,136 citations

Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility.

1997 • 761 citations

Mechanisms of Aflatoxin Carcinogenesis

1994 • 752 citations

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

1997 • 749 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

1998 • 678 citations

Zeta, a novel class of glutathione transferases in a range of species from plants to humans

1997 • 498 citations

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

1998 • 372 citations

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1997 • 338 citations

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

1998 • 323 citations

Glutathione Transferases As Markers Of Preneoplasia And Neoplasia

1989 • 308 citations

Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect

1996 • 301 citations

Glutathione S-Transferases: Gene Structure and Regulation of Expression

1993 • 300 citations

Association Between Glutathione S-Transferase M1, P1, and T1 Genetic Polymorphisms and Development of Breast Cancer

1998 • 299 citations

Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

1996 • 298 citations

Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase

1997 • 263 citations

Glutathione transferases: Nomenclature

1984 • 231 citations

Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera

1997 • 231 citations

Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods

1995 • 217 citations

Chemoprevention by inducers of carcinogen detoxication enzymes.

1997 • 215 citations

Combined effect of polymorphicGST genes on individual susceptibility to lung cancer

1998 • 208 citations

Characterization of the Human Class Mu Glutathione S-Transferase Gene Cluster and the GSTM1Deletion

1998 • 201 citations

Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients

1998 • 188 citations

Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A

1995 • 183 citations

Genetic metabolic polymorphisms and the risk of cancer: a review of the literature

1996 • 182 citations

Identification and Characterization of a Novel Human Microsomal Glutathione S-Transferase with Leukotriene C4 Synthase Activity and Significant Sequence Identity to 5-Lipoxygenase-activating Protein and Leukotriene C4 Synthase

1996 • 169 citations

Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma

1994 • 161 citations

Ligandin heterogeneity: Evidence that the two non-identical subunits are the monomers of two distinct proteins

1977 • 158 citations

Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse: Comparison of the tissue distribution of GST T1-1 with that of classes Alpha, Mu and Pi GST in human

1997 • 154 citations

Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans

1995 • 147 citations

Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12.

1987 • 136 citations

Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate

1993 • 133 citations

Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.

1996 • 129 citations

The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas

1998 • 126 citations

Interactions of α, β-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1

1997 • 125 citations

Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines

1996 • 116 citations

Inhibition of glutathione S-transferase activity in human melanoma cells by α,β-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal

1996 • 112 citations

SHORT COMMUNICATION: Human glutathione S-transferase T1–1 enhances mutagenicity of 1, 2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

1996 • 111 citations

Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.

1993 • 110 citations

Chromosomal Localization of the Gene for the Human Theta Class Glutathione Transferase (GSTT1)

1996 • 99 citations

Structure and organization of the human Theta-class glutathione S-transferase and d-dopachrome tautomerase gene complex

1998 • 94 citations

Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx

1996 • 90 citations

Glucosinolates and phenolics as antioxidants from plant foods.

1998 • 87 citations

Enzymology of Microsomal Glutathione S-Transferase

1994 • 87 citations

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1997 • 82 citations

Ethacrynic acid and its glutathione conjugate as inhibitors of glutathioneS-transferases

1993 • 81 citations

Characterization and chromosome location of the gene GSTZ1 encoding the human Zeta class glutathione transferase and maleylacetoacetate isomerase

1998 • 78 citations

Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells

1998 • 74 citations

Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells.

1994 • 73 citations

Mechanisms of Aflatoxin Carcinogenesis

1994 • 72 citations

Modulation of glutathione conjugation in vivo: how to decrease glutathione conjugation in vivo or in intact cellular systems in vitro

1997 • 63 citations

Sp1-mediated Transcriptional Activation of the Human Pi Class Glutathione S-Transferase Promoter

1996 • 60 citations

Glutathione S-transferases—biomarkers of cancer risk and chemopreventive response

1998 • 59 citations

Genetic Polymorphisms in Human Drug Metabolic Enzymes,

1997 • 56 citations

Chemoprevention by Inducers of Carcinogen Detoxication Enzymes

1997 • 56 citations

Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4

1993 • 49 citations

Allelism at the glutathione S-transferase GSTM3 locus: interactions with GSTM1 and GSTT1 as risk factors for astrocytoma

1996 • 48 citations

A population-based case-control study of the CYP2D6 and GSTTI polymorphisms and malignant brain tumors

1997 • 48 citations

Glutathione S transferase theta 1 gene defects in myelodysplastic syndromes and their correlation with karyotype and exposure to potential carcinogens

1997 • 48 citations

Chromosomal Mapping of the Human Mu Class Glutathione S-Transferases to 1p13

1993 • 41 citations

Coordinate changes in expression of protective genes in drug-resistant cells1For: International Conference on GSH and GSH-linked Enzymes in Human Cancer and Other Diseases.1

1998 • 37 citations

Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma

1997 • 34 citations

Human testicular glutathione S-transferases: insights into tissue-specific expression of the diverse subunit classes

1998 • 26 citations

Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene

1997 • 25 citations

Structure and Function of the 5′ Flanking Sequences of the Human α Class Glutathione S-Transferase Genes

1994 • 24 citations

Combined effect of polymorphic GST genes on individual susceptibility to lung cancer

1998 • 20 citations

Glutathione S-transferases in neonatal liver disease.

1992 • 17 citations

Genetic heterogeneity of the structure and function of GSTT2 and GSTP1

1998 • 17 citations

Identification of thetrans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes and in liver as GST1

1989 • 16 citations

Immunochemical Evidence for the Occurrence of Mu Class Glutath S-Transferase in Human Fetal Livers

1994 • 15 citations

Genetic and individual differences in the process of biotransformation and their relevance for occupational medicine.

1994 • 15 citations