p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates

Glutathione conjugate mediated toxicities*1

1990 • 228 citations

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1986 • 208 citations

The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

1966 • 196 citations

Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution.

1988 • 165 citations

HISTOCHEMICAL AND BIOCHEMICAL INVESTIGATIONS OF GAMMA-GLUTAMYL TRANSPEPTIDASE IN THE TISSUES OF MAN AND LABORATORY RODENTS.

1964 • 127 citations

Glutathione conjugates of 2-bromohydroquinone are nephrotoxic.

1985 • 126 citations

Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis

1978 • 124 citations

Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat

1982 • 121 citations

Contraluminal transport systems in the proximal renal tubule involved in secretion of organic anions

1988 • 115 citations

Bioactivation of xenobiotics by formation of toxic glutathione conjugates

1991 • 105 citations

Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F344 rat

1989 • 97 citations

Acetaminophen nephrotoxicity in the rat

1983 • 93 citations

3-(glutathion-S-yl)acetaminophen: a biliary metabolite of acetaminophen.

1982 • 89 citations

Kidney Lesions Induced in Rats by P-aminophenol

1969 • 83 citations

Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase.

1983 • 83 citations

Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review

1990 • 76 citations

Nephrotoxicity of 4-Aminophenol Glutathione Conjugate

1991 • 76 citations

The nephrotoxicity of p-aminophenol. II. The effect of metabolic inhibitors and inducers

1979 • 64 citations

Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat

1990 • 58 citations

Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation

1989 • 55 citations

Activation and detoxication of aminophenols. II. Synthesis and structural elucidation of various thiol addition products of 1,4-benzoquinoneimine andN-acetyl-1,4-benzoquinoneimine

1990 • 46 citations

Biotransformation of 4-dimethylaminophenol: Reaction with glutathione, and some properties of the reaction products

1976 • 45 citations

The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of γ-glutamyl transpeptidase inhibition

1990 • 37 citations

Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney.

1990 • 36 citations

Renal heterogeneity and target cell toxicity

1986 • 34 citations

Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione

1990 • 34 citations

Activation and detoxication of aminophenols. III. Synthesis and structural elucidation of various glutathione addition products to 1,4-benzoquinone

1990 • 26 citations

The Metabolism of Aminophenols in Erythrocytes

1988 • 26 citations

Cytotoxicity of cysteine S-conjugates: Structure-activity relationships

1989 • 21 citations