Increased skin tumorigenesis in mice lacking pi class glutathione S -transferases

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Glutathione-Associated Enzymes In Anticancer Drug Resistance

2016 • 864 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

1986 • 791 citations

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

1997 • 749 citations

Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

1997 • 716 citations

One-hour downward alkaline capillary transfer for blotting of DNA and RNA

1992 • 551 citations

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.

1985 • 501 citations

Chemoprotection against cancer by Phase 2 enzyme induction

1995 • 454 citations

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk

1997 • 428 citations

Glutathione S-transferases, structure, regulation, and therapeutic implications

1993 • 409 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

Invited Commentary Potential Contribution of the Glutathione S-Transferase Supergene Family to Resistance to Oxidative Stress

1995 • 391 citations

The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis.

1984 • 336 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Glutathione Transferases As Markers Of Preneoplasia And Neoplasia

1989 • 308 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Glutathione and related enzymes in multidrug resistance

1996 • 239 citations

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

1990 • 238 citations

Induction of Phase I and Phase II Drug-Metabolizing Enzyme mRNA, Protein, and Activity by BHA, Ethoxyquin, and Oltipraz

1995 • 189 citations

Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.

1984 • 179 citations

Use of immuno-blot techniques to discriminate between the glutathione S-transferase Yf, Yk, Ya, Yn/Yb and Yc subunits and to study their distribution in extrahepatic tissues. Evidence for three immunochemically distinct groups of transferase in the rat

1986 • 151 citations

The role of glutathione-dependent enzymes in drug resistance

1991 • 142 citations

The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status

1996 • 113 citations

Glutathione S-transferase expression in benign and malignant ovarian tumours

1993 • 102 citations

The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules

1984 • 101 citations

Expression of Glutathione S-Transferase-π in Human Ovarian Cancer as an Indicator of Resistance to Chemotherapy

1994 • 97 citations

Glutathione S-transferase PI (GST-pi) Class Expression by Immunohistochemistry in Benign and Malignant Prostate Tissue

1997 • 91 citations

Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene

1997 • 82 citations

Glutathione S-Transferases in Human and Rodent Skin: Multiple Forms and Species-Specific Expression

1991 • 81 citations

Induction of glutathioneS-transferase π as a bioassay for the evaluation of potency of inhibitors of benzo(a)pyrene-induced cancer in a murine model

1997 • 75 citations

Isolation and characterization of two mouse Pi-class glutathione S-transferase genes

1994 • 73 citations

Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells.

1994 • 73 citations

Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung

1988 • 73 citations

Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines

1989 • 72 citations

Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats

1990 • 66 citations

Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver

1987 • 63 citations

The role of glutathione in determining the response of normal and tumour cells to anticancer drugs

1987 • 54 citations

Glutathione S Transferase Pi Is a Powerful Indicator in Chemotherapy of Human Lung Squamous-Cell Carcinoma

1995 • 54 citations

Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes

1990 • 52 citations

Transgenic mice and squamous multistage skin carcinogenesis

1995 • 50 citations

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer

1993 • 39 citations

Glutathione S-transferase expression in renal cell carcinoma: a new marker of differentiation.

1994 • 36 citations

Amino Acid Differences at Positions 10, 11, and 104 Explain the Profound Catalytic Differences between Two Murine Pi-Class Glutathione S-Transferases

1995 • 32 citations

Increase in placental glutathione S-transferase in human oral epithelial dysplastic lesions and squamous cell carcinomas

1994 • 29 citations

Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene

1997 • 25 citations

Glutathione S-transferases and cancer (Review)

1997 • 25 citations

Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles

1987 • 23 citations

Chemoprotection by Inducers of Electrophile Detoxication Enzymes

1993 • 18 citations

Characterization of a human bladder cancer cell line selected for resistance to BMY 25067, a novel analogue of mitomycin C

1995 • 12 citations

Expression of glutathione S -transferase-π in human ovarian cancer as an indicator of resistance to chemotherapy

1994 • 10 citations

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