Haloenol Lactone: A New Synergist of Chemotherapyin Vitro

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

1987 • 288 citations

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

1988 • 208 citations

Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide.

1996 • 187 citations

Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases

1986 • 159 citations

Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate

1993 • 133 citations

Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil

1990 • 130 citations

Immunohistochemical detection of the placental form of glutathione S-transferase in dysplastic and neoplastic human uterine cervix lesions.

1987 • 127 citations

S-Nitrosation and the reactions of S-nitroso compounds

1985 • 119 citations

Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid.

1991 • 118 citations

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

1987 • 113 citations

Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers.

1990 • 107 citations

A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro

1986 • 104 citations

Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.

1990 • 99 citations

Reduction in cellular glutathione by buthionine sulfbximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard

1984 • 97 citations

Serum glutathione-s-transferase-π as a tumor marker for gastrointestinal malignancies

1989 • 95 citations

Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1.

1994 • 82 citations

The Spontaneous and Glutathione S-Transferase-Mediated Reaction of Chlorambucil with Glutathione

1990 • 66 citations

Inactivation of the genotoxic aldehyde acrolein by human glutathione transferases of classes alpha, mu, and pi.

1990 • 60 citations

Significance of glutathione S-transferase-π as a tumor marker in patients with oral cancer

1992 • 56 citations

Conversion of melphalan to 4-(glutathionyl)phenylalanine. A novel mechanism for conjugation by glutathione-S-transferases.

1987 • 49 citations

Specificity of isozymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalanine mustard.

1991 • 47 citations

Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line.

1989 • 44 citations

Role of glutathione and glutathione S-transferase in chlorambucil resistance.

1992 • 43 citations

Denitrosation of the Anti-Cancer Drug 1,3-Bis(2-chloroethyl)-1-nitrosourea Catalyzed by Microsomal Glutathione S-Transferase and Cytochrome P450 Monooxygenases

1993 • 27 citations

Mitomycin C Sensitivity in Human Bladder Cancer Cells: Possible Role of Glutathione and Glutathione Transferase in Resistance

1994 • 26 citations

Measurement of glutathione S-transferase pi isoenzyme in plasma, a possible marker for adenocarcinoma of the lung

1990 • 26 citations

Modulation of mitomycin C resistance by glutathione transferase inhibitor ethacrynic acid

1992 • 24 citations

Haloenol Lactone Is a New Isozyme-selective and Active Site-directed Inactivator of Glutathione S-Transferase

1996 • 19 citations

Inhibition of glutathione-related enzymes and cytotoxicity of ethacrynic acid and cyclosporine

1995 • 18 citations

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