The role of inflammation in insulitis and β-cell loss in type 1 diabetes

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Origin and physiological roles of inflammation

2008 • 5,579 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

2008 • 2,748 citations

Recognition of microorganisms and activation of the immune response

2007 • 2,700 citations

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

2006 • 2,425 citations

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

2008 • 1,853 citations

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

2005 • 1,413 citations

Induction and effector functions of TH17 cells

2008 • 1,197 citations

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

2008 • 1,161 citations

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

2007 • 1,123 citations

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

2008 • 1,014 citations

Intracellular NOD-like Receptors in Host Defense and Disease

2007 • 1,008 citations

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

2007 • 976 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

2005 • 744 citations

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

2007 • 734 citations

Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

2007 • 553 citations

MDA5/RIG-I and virus recognition

2008 • 552 citations

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

2008 • 511 citations

Cytokines Downregulate the Sarcoendoplasmic Reticulum Pump Ca2+ ATPase 2b and Deplete Endoplasmic Reticulum Ca2+, Leading to Induction of Endoplasmic Reticulum Stress in Pancreatic β-Cells

2005 • 505 citations

TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

2007 • 463 citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library

1999 • 442 citations

IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS

1987 • 437 citations

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

2005 • 417 citations

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

2005 • 382 citations

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

2008 • 355 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

2002 • 289 citations

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

2002 • 285 citations

Viral Trigger for Type 1 Diabetes

2008 • 277 citations

NOD1 variation, immunoglobulin E and asthma

2005 • 269 citations

Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

2004 • 254 citations

Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents

2006 • 240 citations

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

2001 • 231 citations

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

2003 • 224 citations

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

2007 • 193 citations

IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

2003 • 192 citations

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

1999 • 191 citations

Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes

2007 • 191 citations

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

2008 • 182 citations

Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes

1999 • 181 citations

Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease

2003 • 180 citations

A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development

2004 • 179 citations

Elevated Serum IP-10 Levels Observed in Type 1 Diabetes

2001 • 164 citations

Insulin Secretion in Type 1 Diabetes

2004 • 162 citations

Serum concentrations of the interferon-γ-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease

2002 • 160 citations

Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes

2006 • 158 citations

Toll-like Receptor 3 and STAT-1 Contribute to Double-stranded RNA+ Interferon-γ-induced Apoptosis in Primary Pancreatic β-Cells

2005 • 157 citations

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells

2001 • 153 citations

Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

2005 • 148 citations

Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells

2003 • 146 citations

Differential Expression of CC Chemokines and the CCR5 Receptor in the Pancreas Is Associated with Progression to Type I Diabetes

2000 • 144 citations

Caspase-3-Dependent β-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus

2005 • 143 citations

The Effect of Innate Immunity on Autoimmune Diabetes and the Expression of Toll-Like Receptors on Pancreatic Islets

2004 • 140 citations

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets

2005 • 122 citations

Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics

2008 • 110 citations

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

2008 • 110 citations

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes

2004 • 104 citations

Extent of Beta Cell Destruction Is Important but Insufficient to Predict the Onset of Type 1 Diabetes Mellitus

2008 • 102 citations

Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells

2005 • 101 citations

Pathogenesis of ankylosing spondylitis: Current concepts

2006 • 99 citations

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes

2004 • 99 citations

Interferons induce an antiviral state in human pancreatic islet cells

2007 • 97 citations

Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways

2008 • 96 citations

The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection

2002 • 94 citations

Repair of Pancreatic β-cells: A Relevant Phenomenon in Early IDDM?

1993 • 78 citations

Reversal of beta-cell suppression in vitro in pancreatic islets isolated from nonobese diabetic mice during the phase preceding insulin-dependent diabetes mellitus.

1990 • 76 citations

Double-Stranded RNA Cooperates with Interferon-γ and IL-1β to Induce Both Chemokine Expression and Nuclear Factor-κB-Dependent Apoptosis in Pancreatic β-Cells: Potential Mechanisms for Viral-Induced Insulitis and β-Cell Death in Type 1 Diabetes Mellitus

2002 • 74 citations

Chemokines in autoimmune diseases

2000 • 73 citations

Toll‐like receptor 4 suppression leads to islet allograft survival

2007 • 73 citations

Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

2007 • 69 citations

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

2008 • 68 citations

Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus

2005 • 68 citations

Global profiling of double stranded RNA- and IFN-?-induced genes in rat pancreatic beta cells

2003 • 66 citations

Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration

2008 • 56 citations

Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes

2008 • 55 citations

Deletion of STAT-1 Pancreatic Islets Protects Against Streptozotocin-Induced Diabetes and Early Graft Failure but Not Against Late Rejection

2007 • 54 citations

Use of Microarray Analysis to Unveil Transcription Factor and Gene Networks Contributing to β Cell Dysfunction and Apoptosis

2003 • 53 citations

Innate immunity and its role in type 1 diabetes

2008 • 53 citations

Interferon-α as a Mediator of Polyinosinic:Polycytidylic Acid–Induced Type 1 Diabetes

2005 • 51 citations

Use of a systems biology approach to understand pancreatic β-cell death in Type 1 diabetes

2008 • 50 citations

Autoimmunity and β Cell Regeneration in Mouse and Human Type 1 Diabetes

2007 • 48 citations

Islet Expression of M3 Uncovers a Key Role for Chemokines in the Development and Recruitment of Diabetogenic Cells in NOD Mice

2007 • 42 citations

Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis*

2001 • 40 citations

The CVB and Etiology of Type 1 Diabetes

2008 • 39 citations

Regeneration of Pancreatic Endocrine Cells in Interferon-Gamma Transgenic Mice

1992 • 35 citations

Beyond Double-Stranded RNA-Type I IFN Induction by 3pRNA and Other Viral Nucleic Acids

2007 • 34 citations

Notch signaling: A mediator of β-cell de-differentiation in diabetes?

2005 • 29 citations

Dual role of interferon-γ signalling pathway in sensitivity of pancreatic beta cells to immune destruction

2001 • 27 citations

Role of infiltrating T cells for impaired glucose metabolism in pancreatic islets isolated from non-obese diabetic mice

1992 • 10 citations