Use of Microarray Analysis to Unveil Transcription Factor and Gene Networks Contributing to β Cell Dysfunction and Apoptosis

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

NF-κB: a key role in inflammatory diseases

2001 • 3,664 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

High density synthetic oligonucleotide arrays

1999 • 2,256 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Genomics, gene expression and DNA arrays

2000 • 2,039 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Control of apoptosis by Rel/NF-κB transcription factors

1999 • 1,204 citations

Signal transduction through NF-κB

1998 • 1,103 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

1995 • 1,026 citations

β-Cell death during progression to diabetes

2001 • 883 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Inverse Relationship Between Cytotoxicity of Free Fatty Acids in Pancreatic Islet Cells and Cellular Triglyceride Accumulation

2001 • 545 citations

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.

2002 • 516 citations

Mitochondrial function in normal and diabetic β-cells

2001 • 500 citations

Biomedical Discovery with DNA Arrays

2000 • 362 citations

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.

1996 • 328 citations

Interleukin-lβ-Induced Nitric Oxide Production in Isolated Rat Pancreatic Islets Requires Gene Transcription and May Lead to Inhibition of the Krebs Cycle Enzyme Aconitase*

1991 • 317 citations

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1996 • 304 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells*

1997 • 302 citations

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

2002 • 285 citations

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.

1996 • 279 citations

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function

2001 • 255 citations

Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents β-Cell Apoptosis

2001 • 254 citations

Identification of Novel Cytokine-Induced Genes in Pancreatic β-Cells by High-Density Oligonucleotide Arrays

2001 • 231 citations

Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.

1998 • 224 citations

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

1998 • 219 citations

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

2000 • 211 citations

Protection of Human Islets from the Effects of Interleukin-1β by Adenoviral Gene Transfer of an IκB Repressor

2000 • 210 citations

IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

2003 • 192 citations

Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

2002 • 185 citations

Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats

1989 • 183 citations

Expression profiling of pancreatic β cells: Glucose regulation of secretory and metabolic pathway genes

2000 • 181 citations

Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes

1999 • 181 citations

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

1996 • 180 citations

Inhibition of NF?B in activated rat hepatic stellate cells by proteasome inhibitors and an I?B super-repressor

1998 • 178 citations

beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes.

2001 • 175 citations

Administration of Silica Prevents Diabetes in BB-Rats

1985 • 170 citations

Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells

2003 • 168 citations

Cellular and Molecular Mechanisms for the Initiation and Progression of β Cell Destruction Resulting from the Collaboration Between Macrophages and T Cells

1998 • 164 citations

Elevated Serum IP-10 Levels Observed in Type 1 Diabetes

2001 • 164 citations

Inhibition of Proinflammatory Molecule Production by Adenovirus-Mediated Expression of a Nuclear Factor κB Super-Repressor in Human Intestinal Epithelial Cells

1998 • 161 citations

Apoptosis and the pathogenesis of IDDM: a question of life and death.

1998 • 160 citations

Serum concentrations of the interferon-γ-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease

2002 • 160 citations

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells

2001 • 153 citations

Chemokines in autoimmune disease

2001 • 149 citations

Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1.

1997 • 148 citations

Differential Expression of CC Chemokines and the CCR5 Receptor in the Pancreas Is Associated with Progression to Type I Diabetes

2000 • 144 citations

Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin

2002 • 144 citations

The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death

2002 • 140 citations

Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

2002 • 139 citations

Chemokine Regulation of Normal and Pathologic Immune Responses

2001 • 135 citations

Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism.

1998 • 133 citations

Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells

1997 • 113 citations

Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release

2002 • 112 citations

Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage.

2000 • 110 citations

PREVENTION OF AUTOIMMUNE DESTRUCTION OF SYNGENEIC ISLET GRAFTS IN SPONTANEOUSLY DIABETIC NONOBESE DIABETIC MICE BY A COMBINATION OF AVITAMIN D3 ANALOG AND CYCLOSPORINE1

1998 • 106 citations

Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse

2000 • 96 citations

Absolute requirement of macrophages for the development and activation of beta-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice.

1999 • 96 citations

The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection

2002 • 94 citations

Reduced Expression of Th1-Associated Chemokine Receptors on Peripheral Blood Lymphocytes at Diagnosis of Type 1 Diabetes

2002 • 89 citations

Molecular Regulation of Monocyte Chemoattractant Protein-1 Expression in Pancreatic β-Cells

2003 • 87 citations

A Genetic Switch in Pancreatic β-Cells

2002 • 87 citations

Factors controlling pancreatic cell differentiation and function

2001 • 85 citations

Regulated Production and Molecular Diversity of Human Liver and Activation-Regulated Chemokine/Macrophage Inflammatory Protein-3α from Normal and Transformed Cells

2000 • 83 citations

Repair of Pancreatic β-cells: A Relevant Phenomenon in Early IDDM?

1993 • 78 citations

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

2001 • 77 citations

Induction of c-Myc Expression Suppresses Insulin Gene Transcription by Inhibiting NeuroD/BETA2-mediated Transcriptional Activation

2002 • 76 citations

Mice with targeted gene disruptions or gene insertions for diabetes research: problems, pitfalls, and potential solutions

2002 • 75 citations

Cytokine Induction of Fas Gene Expression in Insulin-Producing Cells Requires the Transcription Factors NF-κB and C/EBP

2001 • 74 citations

Double-Stranded RNA Cooperates with Interferon-γ and IL-1β to Induce Both Chemokine Expression and Nuclear Factor-κB-Dependent Apoptosis in Pancreatic β-Cells: Potential Mechanisms for Viral-Induced Insulitis and β-Cell Death in Type 1 Diabetes Mellitus

2002 • 74 citations

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes.

2001 • 73 citations

Chemokines in autoimmune diseases

2000 • 73 citations

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic β-cells

2001 • 71 citations

Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1

2001 • 71 citations

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

2000 • 71 citations

Administration of silica prevents diabetes in BB-rats

1985 • 70 citations

Chemokines, their receptors, and transplant outcome1

2002 • 64 citations

Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis

2001 • 62 citations

Degradation of cellular mRNA is a general early apoptosis‐induced event

2002 • 62 citations

NF-κB Is Required for Cytokine-Induced Manganese Superoxide Dismutase Expression in Insulin-Producing Cells¹

2000 • 61 citations

Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

2000 • 57 citations

The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

1999 • 49 citations

Neuronal apoptosis induced by endoplasmic reticulum stress.

2002 • 46 citations

Both CD4+ and CD8+ T-Cells in Syngeneic Islet Grafts in NOD Mice Produce Interferon-γ During β-Cell Destruction

1996 • 42 citations

Interleukin-1β Induces an Early Decrease in Insulin Release, (Pro)Insulin Biosynthesis and Insulin Mrna in Mouse Pancreatic Islets by a Mechanism Dependent on Gene Transcription and Protein Synthesis

1991 • 38 citations

Dual role of interferon-γ signalling pathway in sensitivity of pancreatic beta cells to immune destruction

2001 • 27 citations

Short-term exposure of rat pancreatic islets to human interleukin-1β increases cellular uptake of calcium

1990 • 26 citations

Repair of pancreatic beta-cells. A relevant phenomenon in early IDDM?

1993 • 26 citations

Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells

1994 • 25 citations

Immunoregulation During Disease Progression in Prediabetic NOD Mice: Inverse Expression of Arginase and Prostaglandin H Synthase 2 vs. Interleukin-15

2002 • 20 citations

Double-Stranded RNA Cooperates with Interferon- and IL-1 to Induce Both Chemokine Expression and Nuclear Factor- B-Dependent Apoptosis in Pancreatic -Cells: Potential Mechanisms for Viral-Induced Insulitis and -Cell Death in Type 1 Diabetes Mellitus

2002 • 16 citations

How Beta Cells Die in Type 1 Diabetes

2001 • 15 citations

Insulin promoter factor-1 controls several aspects of beta-cell identity.

2001 • 10 citations

PDX-1 mediates glucose responsiveness of GAD67, but not GAD65, gene transcription in islets of Langerhans

2002 • 9 citations