A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Untitled

1996 • 780 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Molecular mimicry and immune‐mediated diseases

1998 • 592 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Epidemiologic evidence for multiple sclerosis as an infection

1993 • 467 citations

No one is naive: the significance of heterologous T-cell immunity

2002 • 465 citations

Virus-induced diabetes mellitus

1977 • 433 citations

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes.

2000 • 375 citations

YELLOW NAILS AND LYMPHOEDEMA.

1964 • 370 citations

RUBELLA INFECTION AND DIABETES MELLITUS

1978 • 355 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

2002 • 259 citations

Multiple sclerosis in the faroe islands: I. Clinical and epidemiological features

1979 • 257 citations

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

1986 • 243 citations

Microorganisms and autoimmunity: making the barren field fertile?

2003 • 236 citations

Cross‐reactivity with myelin basic protein and human herpesvirus‐6 in multiple sclerosis

2003 • 226 citations

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

2000 • 212 citations

The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells.

1979 • 207 citations

Multiple sclerosis in the Faroe Islands

2001 • 206 citations

SingleH2Kb, H2Db and doubleH2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses

1999 • 198 citations

A virus-induced molecular mimicry model of multiple sclerosis

2001 • 197 citations

Among CXCR3 Chemokines, IFN-γ-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-γ (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease

2003 • 180 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: Generation, characterization, and cross-reactivity with other arenaviruses

1981 • 176 citations

A virus-induced molecular mimicry model of multiple sclerosis

2001 • 171 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity

1989 • 138 citations

High Frequency of Human Herpesvirus 6 DNA in Multiple Sclerosis Plaques Isolated by Laser Microdissection

2003 • 134 citations

The Role of Viruses and Environmental Factors in the Induction of Diabetes

1990 • 132 citations

Specific History of Heterologous Virus Infections Determines Anti-Viral Immunity and Immunopathology in the Lung

2003 • 128 citations

Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo

2002 • 122 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Analysis of the Relationship between Viral Infection and Autoimmune Disease

2001 • 120 citations

Molecular Mimicry as a Mechanism for the Cause and as a Probe Uncovering Etiologic Agent(s) of Autoimmune Disease

1989 • 119 citations

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

2000 • 116 citations

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient

2004 • 115 citations

Bystander Activation Involving T Lymphocytes in Herpetic Stromal Keratitis

2001 • 95 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

CTL Escape Viral Variants

1995 • 83 citations

Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life

2002 • 78 citations

Pathological Changes in the Islet Milieu Precede Infiltration of Islets and Destruction of β-Cells by Autoreactive Lymphocytes in a Transgenic Model of Virus-Induced IDDM

1997 • 71 citations

Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system

2001 • 63 citations

In Vivo Selection of a Lymphocytic Choriomeningitis Virus Variant That Affects Recognition of the GP33-43 Epitope by H-2D^bbut Not H-2K^b

2001 • 53 citations

Virus-Induced Diabetes in a Transgenic Model: Role of Cross-Reacting Viruses and Quantitation of Effector T Cells Needed To Cause Disease

2000 • 51 citations

The Third Signal in T Cell-Mediated Autoimmune Disease?

2004 • 42 citations

Preferential Escape of Subdominant CD8+ T Cells During Negative Selection Results in an Altered Antiviral T Cell Hierarchy

2003 • 39 citations

Myelin antigen-coupled splenocytes suppress experimental autoimmune encephalomyelitis in Lewis rats through a partially reversible anergy mechanism.

1995 • 32 citations

T-cell receptor crossreactivity and autoimmune disease

2000 • 24 citations

THE DRAMA.

1823 • 21 citations

Serum immunoreactive trypsin concentrations in infectious and non-infectious illnesses and in juvenile diabetes.

1979 • 19 citations

Protection From Type 1 Diabetes in the Face of High Levels of Activated Autoaggressive Lymphocytes in a Viral Transgenic Mouse Model Crossed to the SV129 Strain

2001 • 15 citations