Toll‐like receptor 4 suppression leads to islet allograft survival

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Inferences, questions and possibilities in Toll-like receptor signalling

2004 • 1,458 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice

2004 • 603 citations

Islet isolation assessment in man and large animals

1990 • 575 citations

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

1999 • 493 citations

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

1999 • 489 citations

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1996 • 459 citations

Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway

2004 • 442 citations

Beta-cell adaptation and decompensation during the progression of diabetes.

2001 • 438 citations

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

2007 • 330 citations

Nitric Oxide Induces Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells

1997 • 327 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 305 citations

Saturated and Polyunsaturated Fatty Acids Reciprocally Modulate Dendritic Cell Functions Mediated through TLR4

2005 • 302 citations

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1997 • 297 citations

Heme Oxygenase-1 Induction in Islet Cells Results in Protection From Apoptosis and Improved In Vivo Function After Transplantation

2001 • 263 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 261 citations

TLRs Govern Neutrophil Activity in Aspergillosis

2004 • 237 citations

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans.

1988 • 235 citations

Anti-Inflammatory Actions of the Heme Oxygenase-1 Pathway

2003 • 216 citations

A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets

1999 • 213 citations

Heme oxygenase-1 system in organ transplantation1

2002 • 199 citations

Toll-Like Receptor 4 Is Involved in Outward Arterial Remodeling

2003 • 195 citations

Induction of Heme Oxygenase-1 Expression in Vascular Smooth Muscle Cells

1997 • 192 citations

Effect of tumor necrosis factor-α and interleukin-1α on heme oxygenase-1 expression in human endothelial cells

1998 • 186 citations

Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation

2003 • 164 citations

Toll‐like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS‐responses

2004 • 150 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells

2003 • 146 citations

Phosphoinositide 3 Kinase Mediates Toll-Like Receptor 4-Induced Activation of NF-κB in Endothelial Cells

2003 • 139 citations

TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts

2006 • 128 citations

Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

1999 • 126 citations

Critical Roles of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Type 1 Diabetes

2003 • 121 citations

Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation

2002 • 111 citations

Inhibition of p38 Pathway Suppresses Human Islet Production of Pro‐Inflammatory Cytokines and Improves Islet Graft Function

2005 • 105 citations

Host resistance to infection: genetic control of lipopolysaccharide responsiveness by Toll-like receptor genes

1999 • 95 citations

Donor polymorphisms in Toll‐like receptor‐4 influence the development of rejection after renal transplantation

2005 • 89 citations

Evidence for a Role of Toll-Like Receptor 4 in Development of Chronic Allograft Rejection after Cardiac Transplantation

2004 • 88 citations

Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

2005 • 87 citations

cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle

1997 • 85 citations

Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse

2003 • 81 citations

Heat shock up‐regulates expression of Toll‐like receptor‐2 and Toll‐like receptor‐4 in human monocytes via p38 kinase signal pathway

2005 • 80 citations

Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway

1997 • 73 citations

Interferon-γ-Induced Interferon Regulatory Factor-1 (IRF-1) Expression in Rodent and Human Islet Cells Precedes Nitric Oxide Production¹

1997 • 73 citations

Bilirubin Can Induce Tolerance to Islet Allografts

2005 • 73 citations

A Point Mutation in the IL-12Rβ2 Gene Underlies the IL-12 Unresponsiveness of Lps-Defective C57BL/10ScCr Mice

2001 • 71 citations

Inflammatory mechanisms in diabetes: lessons from the β-cell

2003 • 69 citations

Bacterial Lipoprotein Induces Resistance to Gram-Negative Sepsis in TLR4-Deficient Mice via Enhanced Bacterial Clearance

2005 • 69 citations

Toll-like receptors and innate antiviral responses

2003 • 69 citations

Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle.

2004 • 57 citations

Toll-like receptor 4 is expressed with enteroviral replication in myocardium from patients with dilated cardiomyopathy

2004 • 50 citations

A Significant Role for the Heme Oxygenase-1 Gene in Endothelial Cell Cycle Progression

2002 • 49 citations

Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154

2003 • 45 citations

ALLEVIATION OF GRAFT-VERSUS-HOST DISEASE AFTER CONDITIONING WITH COBALT-PROTOPORPHYRIN, AN INDUCER OF HEME OXYGENASE-1

2000 • 43 citations

Prolonged Allogeneic Islet Graft Survival by Protoporphyrins

2005 • 39 citations

Vascularized Islet Cell Transplantation in Miniature Swine

2002 • 39 citations

Vascularized islet-cell transplantation in miniature swine. I. Preparation of vascularized islet kidneys

2002 • 30 citations

Interferon- -Induced Interferon Regulatory Factor-1 (IRF-1) Expression in Rodent and Human Islet Cells Precedes Nitric Oxide Production

1997 • 17 citations

Differences in Resistance of C57BL/6 and C57BL/10 Mice to Infection byMycobacterium aviumAre Independent of Gamma Interferon

2000 • 9 citations