Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts

Inflammation and metabolic disorders

2006 • 8,000 citations

Inflammation and insulin resistance

2006 • 4,264 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus

2002 • 1,189 citations

Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes

2005 • 1,080 citations

Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes

2004 • 1,032 citations

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 • 880 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Tim-3 inhibits T helper type 1–mediated auto- and alloimmune responses and promotes immunological tolerance

2003 • 674 citations

Less than obvious - statistical treatment of data below the detection limit

1990 • 650 citations

TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

2003 • 595 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC ISLETS

1985 • 548 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

2001 • 441 citations

Attenuation of leptin and insulin signaling by SOCS proteins

2006 • 366 citations

Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

2007 • 339 citations

A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

2005 • 316 citations

IL-15 and IL-2: a matter of life and death for T cells in vivo

2001 • 316 citations

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

2006 • 303 citations

Inhibitory Effects of Interleukin 1 on Insulin Secretion, Insulin Biosynthesis, and Oxidative Metabolism of Isolated Rat Pancreatic Islets*

1987 • 278 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse.

1999 • 191 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

Cure of Overt Diabetes in NOD Mice by Transient Treatment With Anti-Lymphocyte Serum and Exendin-4

2004 • 162 citations

Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis

2004 • 129 citations

Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-Type Hypersensitivity

1998 • 125 citations

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes

2001 • 114 citations

Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance

2006 • 113 citations

CD103 mRNA levels in urinary cells predict acute rejection of renal allografts1

2003 • 104 citations

An Antagonist IL-15/Fc Protein Prevents Costimulation Blockade-Resistant Rejection

2001 • 77 citations

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes

2006 • 70 citations

IL-2 Receptor-Targeted Cytolytic IL-2/Fc Fusion Protein Treatment Blocks Diabetogenic Autoimmunity in Nonobese Diabetic Mice

1999 • 61 citations

Cytokines in the Treatment and Prevention of Autoimmune Responses—A Role of IL-15

2003 • 6 citations