A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors and innate immunity

2001 • 4,138 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases

2002 • 2,592 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2001 • 1,477 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.

1998 • 657 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

2000 • 619 citations

The NOD mouse model of type 1 diabetes: As good as it gets?

1999 • 592 citations

Mammalian Toll-like receptors

2003 • 589 citations

A 1α,25-Dihydroxyvitamin D3 Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice

2002 • 480 citations

The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents

2002 • 469 citations

Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3

1994 • 431 citations

Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

2003 • 396 citations

Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?

2001 • 386 citations

The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7

2002 • 383 citations

A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells

2001 • 302 citations

β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

2002 • 289 citations

Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation

2002 • 285 citations

A new look at viruses in type 1 diabetes

2002 • 264 citations

NIT-1, a Pancreatic β-Cell Line Established From a Transgenic NOD/Lt Mouse

1991 • 254 citations

V<scp>ITAMIN</scp>D<scp>AND ITS</scp>A<scp>NALOGS AS</scp>R<scp>EGULATORS OF</scp>I<scp>MMUNE</scp>A<scp>CTIVATION AND</scp>A<scp>NTIGEN</scp>P<scp>RESENTATION</scp>

2003 • 253 citations

Activation of toll‐like receptor‐9 induces progression of renal disease in MRL‐Fas(lpr) mice

2004 • 210 citations

Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells

2003 • 203 citations

Gene Regulation by Vitamin D3

1998 • 185 citations

Immunostimulation circumvents diabetes in NODLt mice

1989 • 182 citations

Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes

1999 • 181 citations

Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3.

1995 • 180 citations

Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060.

1995 • 177 citations

Elevated Serum IP-10 Levels Observed in Type 1 Diabetes

2001 • 164 citations

Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation

2003 • 163 citations

Serum concentrations of the interferon-γ-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type I diabetes mellitus patients and subjects at risk of developing the disease

2002 • 160 citations

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

1992 • 151 citations

Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells

2003 • 146 citations

Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases

2002 • 143 citations

The Effect of Innate Immunity on Autoimmune Diabetes and the Expression of Toll-Like Receptors on Pancreatic Islets

2004 • 140 citations

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide

2002 • 129 citations

Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes

2002 • 121 citations

Understanding autoimmune diabetes: insights from mouse models

2002 • 118 citations

Direct Transcriptional Regulation of RelB by 1α,25-Dihydroxyvitamin D3 and Its Analogs

2003 • 117 citations

Viruses, host responses, and autoimmunity

1999 • 117 citations

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient

2004 • 115 citations

Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes

2002 • 103 citations

Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat

1992 • 81 citations

Congenic Mapping of the Diabetogenic LocusIdd4to a 5.2-cM Region of Chromosome 11 in NOD Mice

2002 • 73 citations

Immunopathology or Organ‐Specific Autoimmunity as a Consequence of Virus Infection

1996 • 68 citations

CCR4-bearing T cells participate in autoimmune diabetes

2002 • 64 citations

NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice

1992 • 63 citations

Low Dose Poly I:C Prevents Diabetes in the Diabetes Prone BB Rat

1998 • 59 citations

CCR4-bearing T cells participate in autoimmune diabetes

2002 • 59 citations

NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse

1991 • 53 citations

Identification of IL-1β-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA

1999 • 52 citations

Special attractions for suppressor T cells

2003 • 51 citations

Antiinfection Immunity and Autoimmunity

2002 • 43 citations

Poly I:C accelerates development of diabetes mellitus in diabetes-prone BB rat

1992 • 32 citations

Fatal attraction: chemokines and type 1 diabetes

2002 • 20 citations

Is Activation of Autoreactive Lymphocytes Always Detrimental? Viral Infections and Regulatory Circuits in Autoimmunity

2001 • 10 citations