TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

Mechanisms of type-I- and type-II-interferon-mediated signalling

2005 • 3,075 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 • 2,329 citations

RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 • 2,116 citations

TLR signaling

2006 • 1,652 citations

IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors

2004 • 1,635 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

2006 • 1,564 citations

Negative regulation of Toll-like receptor-mediated immune responses

2005 • 1,487 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY

2004 • 1,157 citations

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 • 1,130 citations

Toll-like receptors in systemic autoimmune disease

2006 • 1,079 citations

Plasmacytoid predendritic cells initiate psoriasis through interferon-α production

2005 • 1,063 citations

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

2006 • 1,029 citations

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

2006 • 983 citations

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

2006 • 926 citations

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

2005 • 901 citations

Nod-like proteins in immunity, inflammation and disease

2006 • 866 citations

Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication

2006 • 862 citations

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

2005 • 804 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

Features of systemic lupus erythematosus in Dnase1-deficient mice

2000 • 781 citations

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large

2006 • 775 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Natural autoantibodies: from ‘horror autotoxicus’ to ‘gnothi seauton’

1991 • 723 citations

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

2006 • 704 citations

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

2001 • 673 citations

Cellular and genetic mechanisms of self tolerance and autoimmunity

2005 • 671 citations

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

2006 • 661 citations

ATlr7translocation accelerates systemic autoimmunity in murine lupus

2006 • 611 citations

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I

2005 • 602 citations

Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus

2005 • 591 citations

The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses

2006 • 588 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes

2004 • 522 citations

Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice

2003 • 512 citations

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8

2005 • 506 citations

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

2005 • 504 citations

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

2006 • 444 citations

Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

2003 • 396 citations

Apoptotic Vesicles Crossprime CD8 T Cells and Protect against Tuberculosis

2006 • 392 citations

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

2005 • 382 citations

Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses

2006 • 372 citations

Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN

2006 • 349 citations

Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA

2004 • 347 citations

Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies

2007 • 347 citations

TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE

2006 • 340 citations

The type I interferon system in systemic lupus erythematosus

2006 • 335 citations

Plasmacytoid Dendritic Cells Control TLR7 Sensitivity of Naive B Cells via Type I IFN

2005 • 334 citations

Dendritic Cell Apoptosis in the Maintenance of Immune Tolerance

2006 • 332 citations

Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

2005 • 268 citations

IFN-α Induces Early Lethal Lupus in Preautoimmune (New Zealand Black × New Zealand White)F1 but Not in BALB/c Mice

2005 • 264 citations

U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7

2005 • 259 citations

Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus

2006 • 255 citations

Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice

2006 • 243 citations

Toll‐like receptor 9 signaling protects against murine lupus

2005 • 219 citations

Type I IFN Protects Against Murine Lupus

2004 • 200 citations

Interferons as pathogenic effectors in autoimmunity

2005 • 198 citations

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

2004 • 198 citations

IFN-α Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities

2003 • 184 citations

Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice

2003 • 181 citations

Induction of murine autoimmune disease by chronic polyclonal B cell activation.

1983 • 171 citations

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

2006 • 170 citations

Impairment of T and B Cell Development by Treatment with a Type I Interferon

1998 • 165 citations

Role of TLR9 in Anti-Nucleosome and Anti-DNA Antibody Production in lpr Mutation-Induced Murine Lupus

2006 • 162 citations

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus‐prone NZB × NZW mice

2005 • 134 citations

Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus

2006 • 127 citations

Dna isolated from DNA/anti-DNA antibody immune complexes in systemic lupus erythematosus is rich in guanine-cytosine content.

1982 • 126 citations

The Role of Environmental Antigens in the Spontaneous Development of Autoimmunity in MRL-lprMice

1999 • 125 citations

T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells

2005 • 123 citations

Type I interferon-associated skin recruitment of CXCR3+ lymphocytes in dermatomyositis

2006 • 120 citations

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

2006 • 117 citations

APOPTOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS

2000 • 116 citations

Nucleosome, the Main Autoantigen in Systemic Lupus Erythematosus, Induces Direct Dendritic Cell Activation via a MyD88-Independent Pathway: Consequences on Inflammation

2005 • 112 citations

Endogenous TLR Ligands and Autoimmunity

2006 • 110 citations

Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer.

2003 • 106 citations

Efficient T Cell Activation via a Toll-Interleukin 1 Receptor-Independent Pathway

2006 • 94 citations

Sorting out Toll Signals

2006 • 92 citations

Inefficient Clearance of Dying Cells and Autoreactivity

2006 • 89 citations

Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases

2003 • 86 citations

Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system

2006 • 78 citations

Autoantibodies make a U-turn

2005 • 73 citations

Interferon-β

2005 • 67 citations

‘Toll’ Gates for Future Immunotherapy

2006 • 65 citations

Role of Complement and Other Innate Immune Mechanisms in the Removal of Apoptotic Cells

2005 • 58 citations

Therapeutic targeting of pattern-recognition receptors

2006 • 55 citations

Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll‐like receptor 9–independent pathway

2006 • 48 citations

DNaseI in pathogenesis of systemic lupus erythematosus

2004 • 45 citations

Lupus‐like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p

2006 • 44 citations

Lupus Glomerulonephritis Revisited 2004: Autoimmunity and End‐Organ Damage

2004 • 42 citations

Novel DNASE I mutations related to systemic lupus erythematosus

2004 • 37 citations

Microbial nucleic acids pay a Toll in kidney disease

2006 • 34 citations

TLR9-Independent Activation of B Lymphocytes by Bacterial DNA

2006 • 19 citations

GENES AND GENETICS OF MURINE LUPUS

2004 • 14 citations

Deleted Work

1955 • 0 citations