Metastasis: from dissemination to organ-specific colonization

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Cancer Metastasis: Building a Framework

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

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Epidermal growth factor receptor mutations in lung cancer

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Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

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Genes that mediate breast cancer metastasis to lung

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A molecular signature of metastasis in primary solid tumors

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

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Genomic analysis of metastasis reveals an essential role for RhoC

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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer

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Lysyl oxidase is essential for hypoxia-induced metastasis

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Dissecting the metastatic cascade

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USE OF CHEMOTHERAPY PLUS A MONOCLONAL ANTIBODY AGAINST HER2 FOR METASTATIC BREAST CANCER THAT OVEREXPRESSES HER2

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TGFβ: the molecular Jekyll and Hyde of cancer

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Multistep Nature of Metastatic Inefficiency

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Systemic Spread Is an Early Step in Breast Cancer

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Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

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Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

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Molecular Basis of Metastasis

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TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

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New signals from the invasive front

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Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

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TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

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Comparative lesion sequencing provides insights into tumor evolution

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Genetic determinants of cancer metastasis

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Metastatic patterns in adenocarcinoma

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Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

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Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

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Natural History of Early, Localized Prostate Cancer

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Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

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The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

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From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

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Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

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The Bone Marrow Vascular Niche: Home of HSC Differentiation and Mobilization

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Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch

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Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

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Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

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MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

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ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)

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The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

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Gene expression profiles of primary breast tumors maintained in distant metastases

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The seed and soil hypothesis: vascularisation and brain metastases

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Breast Cancer Metastasis to the Central Nervous System

2005 • 423 citations

Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction

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The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3‐kinase signaling and is frequently lost in colon cancers

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MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

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Dormancy of Mammary Carcinoma After Mastectomy

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Lung metastasis genes couple breast tumor size and metastatic spread

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Metadherin, a cell surface protein in breast tumors that mediates lung metastasis

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GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model

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Genes Associated With Breast Cancer Metastatic to Bone

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NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF

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Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes

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Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

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Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation

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GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis

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Role of Platelets in Tumor Cell Metastases

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Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer

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ID genes mediate tumor reinitiation during breast cancer lung metastasis

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Transcriptional Switch of Dormant Tumors to Fast-Growing Angiogenic Phenotype

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Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

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Breast Cancer

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Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

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Tumor cell α3β1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis

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Isolated Tumor Cells in Bone Marrow Three Years after Diagnosis in Disease-Free Breast Cancer Patients Predict Unfavorable Clinical Outcome1

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Platelet glycoprotein Ibα supports experimental lung metastasis

2007 • 181 citations

Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1

2005 • 180 citations

CNS Metastasis: An Old Problem in a New Guise

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Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

2007 • 173 citations

Twenty‐five years of clinical research for patients with limited‐stage small cell lung carcinoma in North America

2002 • 171 citations

Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth

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Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functionsin vivo

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Requirement of KISS1 Secretion for Multiple Organ Metastasis Suppression and Maintenance of Tumor Dormancy

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Cancer micrometastasis and tumour dormancy

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Tumour dormancy: findings and hypotheses from clinical research on breast cancer

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Organ-Specific Metastatic Tumor Cell Adhesion and Extravasation of Colon Carcinoma Cells with Different Metastatic Potential

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Molecular mechanisms of metastasis

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Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

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Targeted therapy for uveal melanoma

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Metastatic Pancreatic Cancer 2008: Is the Glass Less Empty?

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Modulation of prostate cancer growth in bone microenvironments

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Patterns of metastasis and natural courses of breast carcinoma

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A big step in the study of small cell lung cancer

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A novel mouse model of human breast cancer stem-like cells with high CD44+CD24~/lower phenotype metastasis to human bone

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Lung cancer

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A novel mouse model of human breast cancer stem-like cells with high CD44+CD24-/lower phenotype metastasis to human bone.

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Natural history of cutaneous malignant melanoma

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