Molecular Basis of Metastasis

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Cancer Metastasis: Building a Framework

2006 • 4,071 citations

Dissemination and growth of cancer cells in metastatic sites

2002 • 3,796 citations

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

2004 • 3,727 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression

2000 • 3,504 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

Genes that mediate breast cancer metastasis to lung

2005 • 2,834 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

Distinct Role of Macrophages in Different Tumor Microenvironments

2006 • 2,130 citations

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

2005 • 2,015 citations

Endogenous human microRNAs that suppress breast cancer metastasis

2008 • 1,838 citations

An Oncogene-Induced DNA Damage Model for Cancer Development

2008 • 1,762 citations

Hypoxia signalling in cancer and approaches to enforce tumour regression

2006 • 1,603 citations

The Biology of Cancer

2006 • 1,451 citations

Genomic analysis of metastasis reveals an essential role for RhoC

2000 • 1,449 citations

A causal role for E-cadherin in the transition from adenoma to carcinoma

1998 • 1,415 citations

Concordance among Gene-Expression–Based Predictors for Breast Cancer

2006 • 1,336 citations

Lysyl oxidase is essential for hypoxia-induced metastasis

2006 • 1,302 citations

Direct regulation of TWIST by HIF-1α promotes metastasis

2008 • 1,263 citations

Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer

2006 • 1,213 citations

Multistep Nature of Metastatic Inefficiency

1998 • 1,186 citations

Systemic Spread Is an Early Step in Breast Cancer

2008 • 1,145 citations

Hypoxia, DNA repair and genetic instability

2008 • 1,027 citations

LKB1 modulates lung cancer differentiation and metastasis

2007 • 1,016 citations

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

2004 • 931 citations

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

2007 • 922 citations

Stem Cells and Cancer: Two Faces of Eve

2006 • 909 citations

Brain metastases: epidemiology and pathophysiology

2005 • 901 citations

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

2008 • 888 citations

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

2003 • 864 citations

Genetic determinants of cancer metastasis

2007 • 787 citations

Emerging roles of proteases in tumour suppression

2007 • 771 citations

Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis

2005 • 758 citations

Metastatic patterns in adenocarcinoma

2006 • 751 citations

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

2004 • 699 citations

Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction

2006 • 698 citations

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis

2007 • 697 citations

Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors

2005 • 678 citations

From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

2003 • 619 citations

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

2006 • 605 citations

Pulmonary Metastases From Soft Tissue Sarcoma

1999 • 547 citations

Therapeutic targeting of the tumor microenvironment

2005 • 543 citations

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

2002 • 479 citations

Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

2006 • 393 citations

Migratory neighbors and distant invaders: tumor-associated niche cells

2008 • 379 citations

Lung metastasis genes couple breast tumor size and metastatic spread

2007 • 378 citations

Is cancer a disease of self-seeding?

2006 • 346 citations

The other side of MMPs: Protective roles in tumor progression

2007 • 305 citations

Significance, detection and markers of disseminated breast cancer cells

2006 • 294 citations

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

2005 • 293 citations

Cancer stem cells: implications for the progression and treatment of metastatic disease

2007 • 276 citations

The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis

2006 • 242 citations

The natural course of cutaneous melanoma

2004 • 241 citations

ID genes mediate tumor reinitiation during breast cancer lung metastasis

2007 • 239 citations

Mining gene expression profiles: expression signatures as cancer phenotypes

2007 • 200 citations

Linking oncogenic pathways with therapeutic opportunities

2006 • 167 citations

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

2008 • 104 citations

Genetic evidence for progressive selection and overgrowth of primary tumors by metastatic cell subpopulations.

1988 • 97 citations

Quantitative genetic analysis of tumor progression

1985 • 83 citations

The Problem of Cancer Dormancy: Understanding the Basic Mechanisms and Identifying Therapeutic Opportunities

2006 • 60 citations