Twenty‐five years of clinical research for patients with limited‐stage small cell lung carcinoma in North America

Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group.

1993 • 716 citations

MEDICAL RESEARCH COUNCIL COMPARATIVE TRIAL OF SURGERY AND RADIOTHERAPY FOR PRIMARY TREATMENT OF SMALL-CELLED OR OAT-CELLED CARCINOMA OF BRONCHUS

1973 • 528 citations

Chemotherapy with or without Radiation Therapy in Limited Small-Cell Carcinoma of the Lung

1987 • 484 citations

Twenty-Two Years of Phase III Trials for Patients With Advanced Non–Small-Cell Lung Cancer: Sobering Results

2001 • 359 citations

Twenty Years of Phase III Trials for Patients With Extensive-Stage Small-Cell Lung Cancer: Perceptible Progress

1999 • 351 citations

Long-term survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years--an analysis of 1,714 consecutive patients.

1995 • 267 citations

Chemotherapy Alone or Chemotherapy with Chest Radiation Therapy in Limited Stage Small Cell Lung Cancer

1987 • 225 citations

Prognostic factors for patients with small cell lung carcinoma

2000 • 224 citations

Multimodal therapy for limited small-cell lung cancer: a randomized study of induction combination chemotherapy with or without thoracic radiation in complete responders; and with wide-field versus reduced-field radiation in partial responders: a Southwest Oncology Group Study.

1987 • 212 citations

A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation

1980 • 210 citations

Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: a preliminary report.

1984 • 206 citations

Phase III Comparison of Twice-Daily Split-Course Irradiation Versus Once-Daily Irradiation for Patients With Limited Stage Small-Cell Lung Carcinoma

1999 • 203 citations

Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung

1981 • 191 citations

Chemoradiotherapy with or without granulocyte-macrophage colony-stimulating factor in the treatment of limited-stage small-cell lung cancer: a prospective phase III randomized study of the Southwest Oncology Group.

1995 • 184 citations

Prophylactic Cranial Irradiation in Small Cell Carcinoma of the Lung

1977 • 154 citations

Canadian multicenter randomized trial comparing sequential and alternating administration of two non-cross-resistant chemotherapy combinations in patients with limited small-cell carcinoma of the lung.

1987 • 146 citations

Small cell carcinoma of the lung: Staging, paraneoplastic syndromes, treatment, and survival

1974 • 132 citations

Combination chemotherapy for small cell carcinoma of the lung: continuous versus alternating non-cross-resistant combinations.

1982 • 131 citations

FDG-PET imaging for the staging and follow-up of small cell lung cancer

2001 • 129 citations

Assessment of the Role of Surgery for Control of Lung Cancer

1977 • 128 citations

Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study.

1997 • 122 citations

Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma.

1983 • 109 citations

Thymosin Fraction V and Intensive Combination Chemotherapy

1979 • 108 citations

Thoracic and elective brain irradiation with concomitant or delayed multiagent chemotherapy in the treatment of localized small cell carcinoma of the lung: A randomized prospective study by the southeastern cancer study group

1981 • 80 citations

Small-cell lung cancer: Patients included in clinical trials are not representative of the patient population as a whole

1999 • 79 citations

Sequencing and schedule effects of cisplatin plus etoposide in small-cell lung cancer: results of a North Central Cancer Treatment Group randomized clinical trial.

1994 • 69 citations

Positron Emission Tomography in the Staging of Small-Cell Lung Cancer

2001 • 69 citations

Treatment of limited small-cell lung cancer with etoposide and cisplatin alternating with vincristine, doxorubicin, and cyclophosphamide versus concurrent etoposide, vincristine, doxorubicin, and cyclophosphamide and chest radiotherapy: a Southwest Oncology Group Study.

1990 • 68 citations

Combination chemotherapy with or without thoracic radiotherapy in limited-stage small-cell lung cancer: a randomized trial of the Southeastern Cancer Study Group.

1993 • 66 citations

Prophylactic versus no brain irradiation in regional small cell lung carcinoma

1985 • 65 citations

A case for preplanned thoracic and prophylactic whole brain radiation therapy in limited small-cell lung cancer.

1981 • 59 citations

Treatment of limited-stage small-cell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide: a randomized trial of the North Central Cancer Treatment Group.

1990 • 57 citations

Etoposide combined with cyclophosphamide plus vincristine compared with doxorubicin plus cyclophosphamide plus vincristine and with high-dose cyclophosphamide plus vincristine in the treatment of small-cell carcinoma of the lung: a randomized trial of the Bristol Lung Cancer Study Group.

1989 • 55 citations

Role of radiation therapy in combination with chemotherapy in extensive oat cell cancer of the lung: a randomized study.

1977 • 54 citations

Chemotherapy of small-cell carcinoma of lung: a randomized comparison of alternating and sequential combination chemotherapy programs.

1984 • 50 citations

Combined modality treatment of regional small cell unidifferentiated carcinoma of the lung: A cooperative study of the RTOG and ECOG

1983 • 48 citations

Combined modality therapy with radiotherapy, chemotherapy, and immunotherapy in limited small-cell carcinoma of the lung: a Phase III cancer and Leukemia Group B Study.

1985 • 47 citations

VP-16-213 in combination chemotherapy with chest irradiation for small-cell lung cancer: a randomized trial of the Piedmont Oncology Association.

1984 • 46 citations

Outcome of Patients With Small-Cell Lung Cancer During 20 Years of Clinical Research at the US National Cancer Institute

1997 • 44 citations

Chemotherapy versus chemoimmunotherapy for small-cell undifferentiated carcinoma of the lung

1980 • 42 citations

A Model to Select Chemotherapy Regimens for Phase III Trials for Extensive-Stage Small-Cell Lung Cancer

2000 • 40 citations

Addition of etoposide to cyclophosphamide, doxorubicin and vincristine for remission induction and survival in patients with small cell lung cancer

1987 • 40 citations

Intensive combination chemotherapy, concurrent chest irradiation, and warfarin for the treatment of limited-disease small-cell lung cancer: a Cancer and Leukemia Group B pilot study.

1992 • 40 citations

Combination chemotherapy, radiotherapy, and BCG immunotherapy in limited small-cell carcinoma of the lung: A Southwest Oncology group study

1982 • 37 citations

Late consolidative radiation therapy in the treatment of limited-stage small cell lung cancer

1991 • 36 citations

Intermittent high-dose cyclophosphamide chemotherapy for small cell carcinoma of the lung.

1978 • 36 citations

Cyclophosphamide, doxorubicin, and etoposide as first-line therapy in the treatment of small-cell lung cancer.

1986 • 36 citations

Increased survival with high-dose multifield radiotherapy and intensive chemotherapy in limited small cell carcinoma of the lung

1985 • 35 citations

Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma

1998 • 35 citations

Alternating chemotherapy and thoracic radiotherapy with concurrent cisplatin-etoposide for limited-stage small-cell carcinoma of the lung.

1986 • 33 citations

Treatment of small cell lung cancer with VP-16, vincristine, doxorubicin (Adriamycin), cyclophosphamide (EVAC), and high-dose chest radiotherapy.

1983 • 30 citations

Treatment of small-cell lung cancer on protocol: potential bias of results.

1986 • 24 citations

Long-term survival in small cell carcinoma of the lung

1988 • 22 citations

A randomized trial to compare intravenous and oral etoposide in combination with cisplatin for the treatment of small cell lung cancer

1991 • 22 citations

Combination chemotherapy-radiotherapy with and without the methanol-extraction residue of bacillus calmette-guerin (MER) in small cell carcinoma of the lung a prospective randomized trial of the piedmont oncology association

1982 • 20 citations

A Phase I-II Study of Sequential Infusion VP-16 and Cisplatin Therapy in Advanced Lung Cancer

1989 • 18 citations

Phase II studies of polychemotherapy regimens in small cell lung cancer.

1977 • 16 citations

An evaluation of low-dose cisplatin as part of combined modality therapy of limited small cell lung cancer.

1981 • 8 citations

Chemotherapy Plus RA233 in the Treatment of Oat Cell Lung Cancer

1989 • 5 citations

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