Cancer micrometastasis and tumour dormancy

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Dissemination and growth of cancer cells in metastatic sites

2002 • 3,796 citations

Tumorigenesis and the angiogenic switch

2003 • 3,398 citations

Genes that mediate breast cancer metastasis to lung

2005 • 2,834 citations

A multigenic program mediating breast cancer metastasis to bone

2003 • 2,539 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

2007 • 2,297 citations

Models, mechanisms and clinical evidence for cancer dormancy

2007 • 1,523 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Reversal of human cellular senescence: roles of the p53 and p16 pathways

2003 • 1,342 citations

A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer

2005 • 1,333 citations

Adaptive immunity maintains occult cancer in an equilibrium state

2007 • 1,307 citations

Dissecting the metastatic cascade

2004 • 1,268 citations

Detection, clinical relevance and specific biological properties of disseminating tumour cells

2008 • 1,098 citations

Biological Diversity in Metastatic Neoplasms: Origins and Implications

1982 • 937 citations

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

2004 • 909 citations

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

2004 • 842 citations

Metastasis genes: A progression puzzle

2002 • 793 citations

Genetic determinants of cancer metastasis

2007 • 787 citations

Metastasis: recent discoveries and novel treatment strategies

2007 • 699 citations

Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype

2006 • 654 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

STAT proteins: From normal control of cellular events to tumorigenesis

2003 • 603 citations

Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling

1999 • 520 citations

A New Description of Cellular Quiescence

2006 • 511 citations

Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch

2006 • 483 citations

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

2002 • 479 citations

ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)

2004 • 451 citations

Urokinase Receptor and Fibronectin Regulate the ERK^MAPK to p38^MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo

2001 • 422 citations

Metastatic Inefficiency

1990 • 407 citations

The power and the promise of oncogene-induced senescence markers

2006 • 398 citations

Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity

2005 • 389 citations

Lack of Effect of Adjuvant Chemotherapy on the Elimination of Single Dormant Tumor Cells in Bone Marrow of High-Risk Breast Cancer Patients

2000 • 387 citations

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

2002 • 386 citations

Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction.

1994 • 382 citations

Functional Coupling of p38-Induced Up-regulation of BiP and Activation of RNA-Dependent Protein Kinase–Like Endoplasmic Reticulum Kinase to Drug Resistance of Dormant Carcinoma Cells

2006 • 317 citations

Methodological Analysis of Immunocytochemical Screening for Disseminated Epithelial Tumor Cells in Bone Marrow

1994 • 312 citations

Combined transcriptome and genome analysis of single micrometastatic cells

2002 • 301 citations

HER2-Positive Circulating Tumor Cells Indicate Poor Clinical Outcome in Stage I to III Breast Cancer Patients

2006 • 261 citations

Individual development and uPA–receptor expression of disseminated tumour cells in bone marrow: A reference to early systemic disease in solid cancer

1995 • 253 citations

Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer

2005 • 250 citations

A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation

2006 • 226 citations

Molecular signature associated with bone marrow micrometastasis in human breast cancer.

2003 • 226 citations

Comparative analysis of bone marrow and venous blood isolates from gastrointestinal cancer patients for the detection of disseminated tumor cells using reverse transcription PCR.

1997 • 224 citations

Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo

2002 • 220 citations

Tumor dormancy and surgery-driven interruption of dormancy in breast cancer: learning from failures

2007 • 192 citations

Metastasis Suppression: The Evolving Role of Metastasis Suppressor Genes for Regulating Cancer Cell Growth at the Secondary Site

2003 • 187 citations

Isolated Tumor Cells in Bone Marrow Three Years after Diagnosis in Disease-Free Breast Cancer Patients Predict Unfavorable Clinical Outcome1

2004 • 186 citations

Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1

2005 • 180 citations

The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence

2005 • 174 citations

Tumor Dormancy and Cancer Stem Cells: Implications for the Biology and Treatment of Breast Cancer Metastasis

2007 • 169 citations

Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth

2004 • 168 citations

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

2004 • 168 citations

Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen

1981 • 167 citations

Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors

2002 • 163 citations

In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis

2004 • 162 citations

Stromal cell-derived factor-1α (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation

2005 • 161 citations

Requirement of KISS1 Secretion for Multiple Organ Metastasis Suppression and Maintenance of Tumor Dormancy

2007 • 157 citations

CXCL-12/Stromal Cell–Derived Factor-1α Transactivates HER2-neu in Breast Cancer Cells by a Novel Pathway Involving Src Kinase Activation

2005 • 157 citations

uPAR and HER-2 gene status in individual breast cancer cells from blood and tissues

2006 • 155 citations

Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer

2007 • 146 citations

Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-gamma in establishing and maintaining the tumor-dormant state.

1999 • 142 citations

Metastasis Suppressor Genes: Basic Biology and Potential Clinical Use

2003 • 138 citations

Prostate cancer metastasis: Role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis

2006 • 137 citations

Comparison of HER2 status between primary tumor and disseminated tumor cells in␣primary breast cancer patients

2006 • 129 citations

Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application

2006 • 128 citations

Host genetics influence tumour metastasis

2006 • 126 citations

Integrin α5β1 Promotes Survival of Growth-Arrested Breast Cancer Cells

2004 • 124 citations

Medroxyprogesterone Acetate Elevation of Nm23-H1 Metastasis Suppressor Expression in Hormone Receptor–Negative Breast Cancer

2005 • 123 citations

Cancer Dormancy. VII. A Regulatory Role for CD8+ T Cells and IFN-γ in Establishing and Maintaining the Tumor-Dormant State

1999 • 123 citations

Germline polymorphisms in SIPA1are associated with metastasis and other indicators of poor prognosis in breast cancer

2006 • 118 citations

Review article: Micrometastasis in colorectal carcinoma: A review

1998 • 106 citations

Genomic Profiling of Viable and Proliferative Micrometastatic Cells from Early-Stage Breast Cancer Patients

2004 • 106 citations

Tumor Microenvironment Promotes Cancer Progression, Metastasis, and Therapeutic Resistance

2007 • 105 citations

Tumor cell dormancy: An NCI workshop report

2007 • 102 citations

Immunocytochemical Detection of Disseminated Tumor Cells in the Bone Marrow of Patients With Esophageal Carcinoma

1996 • 99 citations

Prognostic Significance of Micrometastasis in Non–Small-Cell Lung Cancer

2004 • 97 citations

Genomic Profiles Associated with Early Micrometastasis in Lung Cancer: Relevance of 4q Deletion

2009 • 96 citations

Elevation of breast carcinoma Nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition.

2001 • 94 citations

Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy

2006 • 94 citations

Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survival

2005 • 94 citations

Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients

2005 • 92 citations

A comparative analysis of three different techniques for the detection of breast cancer cells in bone marrow

1991 • 91 citations

Urokinase-Receptor (u-PAR)–An Essential Player in Multiple Games of Cancer: A Review on Its Role in Tumor Progression, Invasion, Metastasis, Proliferation/dormancy, Clinical Outcome and Minimal Residual Disease

2006 • 91 citations

Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients

2003 • 89 citations

Systemic Cancer Progression and Tumor Dormancy: Mathematical Models Meet Single Cell Genomics

2006 • 87 citations

Isolation of blood-borne epithelium-derived c-erbB-2 oncoprotein-positive clustered cells from the peripheral blood of breast cancer patients

1998 • 85 citations

Clinical significance of micrometastasis in lung and esophageal cancer: a new paradigm in thoracic oncology

2002 • 82 citations

The clinical significance of disseminated tumor cells in breast cancer

2006 • 76 citations

Minimal Residual Disease in Gastric Cancer: Evidence of an Independent Prognostic Relevance of Urokinase Receptor Expression by Disseminated Tumor Cells in the Bone Marrow

2002 • 74 citations

The Prognostic Value of Isolated Tumor Cells in Bone Marrow in Breast Cancer Patients

2004 • 71 citations

Limitations of cytokeratin 20 RT-PCR to detect disseminated tumour cells in blood and bone marrow of patients with colorectal cancer: expression in controls and downregulation in tumour tissue

2002 • 69 citations

Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: Results at 4 years

2004 • 68 citations

Detection of isolated tumor cells in peripheral blood and in BM: evaluation of a new enrichment method

2004 • 68 citations

Detection and Quantification of Small Numbers of Circulating Tumour Cells in Peripheral Blood Using Laser Scanning Cytometer (LSC®)

2001 • 66 citations

Detection and characterization of circulating and disseminated prostate cancer cells

2007 • 64 citations

Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients

2007 • 60 citations

The Problem of Cancer Dormancy: Understanding the Basic Mechanisms and Identifying Therapeutic Opportunities

2006 • 60 citations

Immunomagnetic detection of micrometastatic cells in bone marrow of colorectal cancer patients.

2002 • 60 citations

Detection of Circulating Prostate-Specific Antigen–Secreting Cells in Prostate Cancer Patients

2005 • 59 citations

Cancer Dormancy from Mice to Man: A Review

2006 • 59 citations

Influence of platinum-based chemotherapy on disseminated tumor cells in blood and bone marrow of patients with ovarian cancer

2007 • 55 citations

Molecular Detection of Circulating Cancer Cells

2003 • 52 citations

Enrichment methods to detect bone marrow micrometastases in breast carcinoma patients: clinical relevance

2004 • 49 citations

The tumor dormant state. Quantitation of L5178Y cells and host immune responses during the establishment and course of dormancy in syngeneic DBA/2 mice.

1979 • 49 citations

Mathematical models of cancer dormancy

2004 • 46 citations

Addressing the Role of Cell Adhesion in Tumor Cell Dormancy

2006 • 44 citations

Dormant Tumors Awaken by a Short-Term Angiogenic Burst: The Spike Hypothesis

2006 • 44 citations

A relevant immunomagnetic assay to detect and characterize epithelial cell adhesion molecule‐positive cells in bone marrow from patients with breast carcinoma

2004 • 44 citations

The detection and isolation of viable prostate-specific antigen positive epithelial cells by enrichment: A comparison to standard prostate-specific antigen reverse transcriptase polymerase chain reaction and its clinical relevance in prostate cancer

2007 • 43 citations

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis.

2004 • 39 citations

Optimisation of the RT-PCR detection of immunomagnetically enriched carcinoma cells

2002 • 37 citations

Detection of MAGE-A Transcripts in Bone Marrow Is an Independent Prognostic Factor in Operable Non–Small-Cell Lung Cancer

2007 • 36 citations

Detection and clinical implications of minimal residual disease in gastro-intestinal cancer

2005 • 35 citations

A European interlaboratory testing of three well‐known procedures for immunocytochemical detection of epithelial cells in bone marrow. Results from analysis of normal bone marrow

2006 • 35 citations

Detection of bone marrow‐disseminated breast cancer cells using an RT‐PCR assay of MUC5B mRNA

2002 • 35 citations

Cancer Interaction with the Bone Microenvironment

2006 • 35 citations

Molecular detection of micrometastases and circulating tumor cells in melanoma prostatic and breast carcinomas.

2000 • 32 citations

Interference of Cytokeratin-20 and Mammaglobin-Reverse-Transcriptase Polymerase Chain Assays Designed for the Detection of Disseminated Cancer Cells

2001 • 30 citations

Detection and quantification of circulating tumor cells in patients with esophageal cancer by real-time polymerase chain reaction.

2004 • 29 citations

Detection of cancer cells disseminated in bone marrow using real-time quantitative RT-PCR of CEA, CK19, and CK20 mRNA in patients with gastric cancer

2006 • 27 citations

Does the immunocytochemical detection of epithelial cells in bone marrow (micrometastasis) influence the time to biochemical relapse after radical prostatectomy?

1999 • 26 citations

Tumor Dormancy: Death and Resurrection of Cancer As Seen through Transgenic Mouse Models

2006 • 26 citations

A Comparison of Immunohistochemistry, Two-Color Immunofluorescence, and Flow Cytometry with Cell Sorting for the Detection of Micrometastatic Breast Cancer in the Bone Marrow

1996 • 25 citations

Immunobead-Based Detection and Characterization of Circulating Tumor Cells in Melanoma Patients

2001 • 25 citations

Tumor Dormancy and the Role of Metastasis Suppressor Genes In Regulating Ectopic Growth

2006 • 25 citations

Cancer Dormancy: Lessons from a B Cell Lymphoma and Adenocarcinoma of the Prostate

2007 • 22 citations

Supersensitive PSA-Monitored Neoadjuvant Hormone Treatment of Clinically Localized Prostate Cancer: Effects on Positive Margins, Tumor Detection and Epithelial Cells in Bone Marrow

1998 • 20 citations

Investigations for a multi-marker RT-PCR to improve sensitivity of disseminated tumor cell detection.

2003 • 19 citations

Survival of leukemic cells in a dormant state following cyclophosphamide‐induced cure of strongly immunogenic mouse leukemia (DL811)

1991 • 19 citations

Bone marrow micrometastasis detected by RT-PCR in esophageal squamous cell carcinoma

2003 • 18 citations

Clinical significance of bone marrow micrometastases in esophageal cancer

2004 • 17 citations

Detection of Micrometastasis Through Tissue-Specific Gene Expression: Its Promise and Problems

2001 • 17 citations

Influence of immunomagnetic enrichment on gene expression of tumor cells.

2005 • 16 citations

Clinical evaluation of a panel of mRNA markers in the detection of disseminated tumor cells in patients with operable breast cancer

2005 • 14 citations

Prognostic influence of minimal residual disease detected by flow cytometry and peripheral blood stem cell transplantation by CD34⁺ selection in childhood advanced neuroblastoma

2007 • 11 citations

Persistence of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients predicts increased risk for relapse—Results of pooled European data

2006 • 9 citations

An immunomagnetic epithelial tumor cell enrichment model for minimal residual disease detection of cytokeratin 8+ malignancies.

2005 • 5 citations

Bone marrow and sentinel lymph node biopsy in patients with breast cancer: from staging to ultrastaging?

2006 • 2 citations