Cell Motility and Cytoskeletal Regulation in Invasion and Metastasis

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

Trastuzumab-Induced Hepatotoxicity: A Case Report

2013 • 4,369 citations

Cancer Metastasis: Building a Framework

2006 • 4,071 citations

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

Cell Migration: A Physically Integrated Molecular Process

1996 • 3,909 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

Met, metastasis, motility and more

2003 • 2,526 citations

The Many Roles of Chemokines and Chemokine Receptors in Inflammation

2006 • 2,425 citations

The epithelial–mesenchymal transition: new insights in signaling, development, and disease

2006 • 1,987 citations

Epidermal growth factor receptor (EGFR) signaling in cancer

2005 • 1,852 citations

Dissecting the metastatic cascade

2004 • 1,268 citations

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

2005 • 1,136 citations

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2004 • 1,127 citations

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

2003 • 1,109 citations

Regulation of the actin cytoskeleton in cancer cell migration and invasion

2006 • 1,071 citations

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

1999 • 968 citations

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

2003 • 926 citations

The WASP–WAVE protein network: connecting the membrane to the cytoskeleton

2006 • 915 citations

Intravital imaging of cell movement in tumours

2003 • 908 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

2005 • 714 citations

CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

2004 • 707 citations

Rho GTPases and the control of cell behaviour

2005 • 706 citations

Prespecification and plasticity: shifting mechanisms of cell migration

2004 • 658 citations

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility

2004 • 652 citations

Phosphoinositide Regulation of the Actin Cytoskeleton

2003 • 644 citations

Molecular mechanisms of invadopodium formation

2005 • 637 citations

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

2003 • 579 citations

The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors

2003 • 578 citations

Rho GTPases and the control of cell behaviour

2005 • 545 citations

c-Met: structure, functions and potential for therapeutic inhibition.

2003 • 494 citations

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

2002 • 479 citations

The Stromal Derived Factor–1/CXCL12–CXC Chemokine Receptor 4 Biological Axis in Non–Small Cell Lung Cancer Metastases

2003 • 455 citations

Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors

2004 • 452 citations

β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis

2006 • 447 citations

Chemokines and cancer

2006 • 413 citations

THE GREAT ESCAPE: When Cancer Cells Hijack the Genes for Chemotaxis and Motility

2005 • 383 citations

Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion

2005 • 378 citations

Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?

2004 • 344 citations

Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 Complex

2002 • 320 citations

Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues

2004 • 287 citations

Functions of CXCL12 and CXCR4 in breast cancer

2005 • 272 citations

The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia

2005 • 262 citations

Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma

2003 • 261 citations

The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors

2006 • 259 citations

The multifaceted roles of chemokines in malignancy

2006 • 248 citations

Molecular details of formin-mediated actin assembly

2005 • 246 citations

Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo

2002 • 243 citations

WAVE2 is required for directed cell migration and cardiovascular development

2003 • 239 citations

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

2002 • 226 citations

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

2004 • 226 citations

Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer

2006 • 203 citations

Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium

2006 • 201 citations

Epidermal Growth Factor Receptor Overexpression Results in Increased Tumor Cell Motility In vivo Coordinately with Enhanced Intravasation and Metastasis

2006 • 186 citations

PIP2 signaling in lipid domains: a critical re-evaluation

2005 • 183 citations

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

2006 • 177 citations

Spatial and Temporal Control of Cofilin Activity Is Required for Directional Sensing during Chemotaxis

2006 • 157 citations

Membrane binding domains

2006 • 156 citations

Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells

2004 • 150 citations

Autocrine and Juxtacrine Effects of Amphiregulin on the Proliferative, Invasive, and Migratory Properties of Normal and Neoplastic Human Mammary Epithelial Cells

2006 • 145 citations

The early steps of neural crest development

2001 • 119 citations

Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo.

2003 • 114 citations

Differential Functional Activation of Chemokine Receptor CXCR4 Is Mediated by G Proteins in Breast Cancer Cells

2006 • 109 citations

Agonist-induced PIP₂Hydrolysis Inhibits Cortical Actin Dynamics: Regulation at a Global but not at a Micrometer Scale

2002 • 99 citations

ErbB3-Dependent Motility and Intravasation in Breast Cancer Metastasis

2006 • 93 citations

Mechanisms of Gradient Sensing and Chemotaxis: Conserved Pathways, Diverse Regulation

2006 • 86 citations

Navigating signaling networks: chemotaxis in Dictyostelium discoideum

2006 • 80 citations

PI3K and RAC signalling in leukocyte and cancer cell migration.

2006 • 73 citations

Chemotactic cell movement during development

2003 • 70 citations

Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production

2003 • 70 citations

Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy

2004 • 60 citations

Receptor Tyrosine Kinases as Therapeutic Targets the Model of the MET Oncogene

2001 • 59 citations

Role of chemokines in the development of secondary and tertiary lymphoid tissues

2003 • 58 citations

Roles for neuregulins in human cancer

2005 • 53 citations

Tyrosine kinase signalling in breast cancer: Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates

2000 • 26 citations