Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

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Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

Stochasticity in gene expression: from theories to phenotypes

2005 • 2,347 citations

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

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Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

2004 • 1,600 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

The age of cancer

2000 • 949 citations

Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

2000 • 927 citations

A Mutator Phenotype in Cancer 1

2001 • 675 citations

From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression

2003 • 619 citations

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer

2002 • 479 citations

Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells

1999 • 449 citations

Histological and biological evolution of human premalignant breast disease.

2001 • 424 citations

Lack of Effect of Adjuvant Chemotherapy on the Elimination of Single Dormant Tumor Cells in Bone Marrow of High-Risk Breast Cancer Patients

2000 • 387 citations

In situ analyses of genome instability in breast cancer

2004 • 354 citations

Comparative genomic hybridization of ductal carcinomain situ of the breast?evidence of multiple genetic pathways

1999 • 334 citations

Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.

1996 • 301 citations

Detection of Isolated Tumor Cells in Bone Marrow Is an Independent Prognostic Factor in Breast Cancer

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Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy

2000 • 253 citations

Modeling stochastic gene expression: Implications for haploinsufficiency

1998 • 244 citations

Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast

1998 • 239 citations

Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way

2004 • 213 citations

Epithelial Cells in Bone Marrow of Breast Cancer Patients at Time of Primary Surgery: Clinical Outcome During Long-Term Follow-Up

2001 • 203 citations

The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence

2005 • 174 citations

Simultaneous Immunohistochemical Detection of Tumor Cells in Lymph Nodes and Bone Marrow Aspirates in Breast Cancer and Its Correlation With Other Prognostic Factors

2001 • 173 citations

Chromosomal Alterations in Ductal Carcinomas In Situ and Their In Situ Recurrences

2000 • 166 citations

Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions

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Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase

1998 • 147 citations

Aneuploidy, the Primary Cause of the Multilateral Genomic Instability of Neoplastic and Preneoplastic Cells

2004 • 132 citations

Extensive ductal carcinomaIn situ with small foci of invasive ductal carcinoma: Evidence of genetic resemblance by CGH

2000 • 95 citations

Genomic Organization of the Human β-Catenin Gene (CTNNB1)

1996 • 93 citations

Tyrosine kinase inhibitors

2004 • 89 citations

SCOMP Is Superior to Degenerated Oligonucleotide Primed-Polymerase Chain Reaction for Global Amplification of Minute Amounts of DNA from Microdissected Archival Tissue Samples

2002 • 83 citations

The Systemic Progression of Human Cancer: A Focus on the Individual Disseminated Cancer Cell—The Unit of Selection

2003 • 66 citations

E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice

2000 • 54 citations