Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

2004 • 11,620 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Culture of Animal Cells

1983 • 3,334 citations

Java Treeview—extensible visualization of microarray data

2004 • 2,963 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

The multistep nature of cancer

1993 • 1,872 citations

Culture of Animal Cells: A Manual of Basic Technique

1985 • 1,258 citations

Modelling the molecular circuitry of cancer

2002 • 948 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

X chromosomal abnormalities in basal-like human breast cancer

2006 • 838 citations

Rosen's Breast Pathology

1997 • 834 citations

Keratin expression in human tissues and neoplasms

2002 • 809 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

2002 • 604 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

Stem cells in normal breast development and breast cancer

2003 • 551 citations

Stem cells in normal breast development and breast cancer

2003 • 544 citations

Species- and cell type-specific requirements for cellular transformation

2004 • 542 citations

Rosen's Breast Pathology

2002 • 523 citations

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

2003 • 511 citations

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

2000 • 491 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Is cancer a disease of self-seeding?

2006 • 346 citations

RETRACTED: Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

2003 • 323 citations

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

2003 • 316 citations

Genes involved in senescence and immortalization

2000 • 306 citations

Common Adult Stem Cells in the Human Breast Give Rise to Glandular and Myoepithelial Cell Lineages: A New Cell Biological Concept

2002 • 284 citations

Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer

2005 • 278 citations

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

2003 • 277 citations

A Genetically Defined Model for Human Ovarian Cancer

2004 • 275 citations

Stochastic Models Inspired by Hybridization Theory for Short Oligonucleotide Arrays

2005 • 268 citations

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

1998 • 266 citations

Culture of Epithelial Cells

2002 • 264 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 258 citations

Immortalization and transformation of primary human airway epithelial cells by gene transfer

2002 • 253 citations

Expression Profiling of Purified Normal Human Luminal and Myoepithelial Breast Cells

2004 • 248 citations

A Mouse Model of Human Breast Cancer Metastasis to Human Bone

2005 • 205 citations

Loss of Heterozygosity and Its Correlation with Expression Profiles in Subclasses of Invasive Breast Cancers

2004 • 191 citations

Methylation of the human telomerase gene CpG island.

2000 • 180 citations

BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles

2005 • 162 citations

Mammary epithelial cell transformation: insights from cell culture and mouse models

2005 • 152 citations

Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma

2002 • 133 citations

Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data

2006 • 133 citations

Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma

2003 • 126 citations

Derivation of human tumor cells in vitro without widespread genomic instability.

2001 • 126 citations

Isolation and characterization of functional mammary gland stem cells

2003 • 113 citations

Genetic and Epigenetic Changes in Mammary Epithelial Cells May Mimic Early Events in Carcinogenesis

2004 • 84 citations

p16INK4a inactivation is not required to immortalize human mammary epithelial cells

2002 • 83 citations

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

2000 • 58 citations

Culture models of human mammary epithelial cell transformation.

2000 • 55 citations

Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia.

2005 • 53 citations

Correlation of tumor volume and surface area with lymph node status in patients with multifocal/multicentric breast carcinoma

2004 • 46 citations

Tumour biology of a breast cancer at least partly reflects the biology of the tissue/epithelial cell of origin at the time of initiation — a hypothesis

2000 • 23 citations

Epigenetic changes accompanying human mammary epithelial cell immortalization.

2001 • 13 citations