Metastasis to bone: causes, consequences and therapeutic opportunities

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Cancer statistics, 1995

1995 • 1,434 citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

2000 • 1,414 citations

TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1999 • 969 citations

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.

1996 • 846 citations

Tumor heterogeneity and the biology of cancer invasion and metastasis.

1978 • 833 citations

Multiple myeloma: evolving genetic events and host interactions

2002 • 815 citations

Reduction in New Metastases in Breast Cancer with Adjuvant Clodronate Treatment

1998 • 811 citations

Parathyroid hormone-related protein purified from a human lung cancer cell line.

1987 • 735 citations

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

1995 • 627 citations

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord

2000 • 496 citations

Prostaglandins as Mediators of Hypercalcemia Associated with Certain Types of Cancer

1975 • 461 citations

Molecular mechanisms of cancer pain

2002 • 459 citations

Osteoprotegerin inhibits prostate cancer–induced osteoclastogenesis and prevents prostate tumor growth in the bone

2001 • 453 citations

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

1995 • 421 citations

Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.

1991 • 384 citations

Effects of basic fibroblast growth factor on bone formation in vitro.

1988 • 375 citations

The Cellular Basis of Site-Specific Tumor Metastasis

1990 • 349 citations

Adjuvant Clodronate Treatment Does Not Reduce the Frequency of Skeletal Metastases in Node-Positive Breast Cancer Patients: 5-Year Results of a Randomized Controlled Trial

2001 • 346 citations

Bisphosphonate treatment inhibits the growth of prostate cancer cells.

2001 • 345 citations

Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts

1994 • 328 citations

Quantitative Bone Histomorphometry in Humoral Hypercalcemia of Malignancy: Uncoupling of Bone Cell Activity*

1982 • 277 citations

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer.

1997 • 275 citations

Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.

1995 • 273 citations

Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.

1988 • 271 citations

Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis

1995 • 244 citations

The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.

2001 • 244 citations

Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.

1990 • 243 citations

Markers of bone turnover for the management of patients with bone metastases from prostate cancer

2000 • 238 citations

Structural requirements for the growth factor activity of the amino-terminal domain of urokinase.

1992 • 236 citations

N-Terminal amino acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: Identification of parathyroid hormone-like and parathyroid hormone-unlike domains

1987 • 229 citations

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

1994 • 225 citations

In VivoStimulation of Endosteal Bone Formation by Basic Fibroblast Growth Factor in Rats

1993 • 221 citations

Histomorphometric analysis of sclerotic bone metastases from prostatic carcinoma with special reference to osteomalacia

1983 • 207 citations

Extracellular Calcium-Sensing Receptor Expression and Its Potential Role in Regulating Parathyroid Hormone-Related Peptide Secretion in Human Breast Cancer Cell Lines*

2000 • 203 citations

Prostate Specific Antigen Cleaves Parathyroid Hormone-Related Protein in the PTH-like Domain: Inactivation of PTHrP-Stimulated cAMP Accumulation in Mouse Osteoblasts

1996 • 194 citations

An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells

1990 • 177 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer.

2002 • 170 citations

A Potential Role for Interleukin-8 in the Metastatic Phenotype of Breast Carcinoma Cells

2001 • 168 citations

Comparative study of available medical therapy for hypercalcemia of malignancy

1983 • 167 citations

Scanning electron microscopy in bone pathology: review of methods, potential and applications.

1986 • 160 citations

Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen

1996 • 140 citations

Complete amino acid sequence of human transforming growth factor type beta 2.

1987 • 139 citations

Cancer Invasion and Metastases

1990 • 136 citations

Biochemical and histological evidence that carcinoma of the prostate is associated with increased bone resorption.

1987 • 128 citations

Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.

1989 • 127 citations

Systemic Administration of Acidic Fibroblast Growth Factor (FGF-1) Prevents Bone Loss and Increases New Bone Formation in Ovariectomized Rats

1999 • 121 citations

Parathyroid Hormone-Related Protein Production by Breast Cancers, Improved Survival, and Reduced Bone Metastases

2001 • 119 citations

Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy.

2001 • 117 citations

Ca²⁺-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells

2001 • 114 citations

Bisphosphonates in prostate carcinoma

1997 • 107 citations

Paracrine/autocrine regulation of breast cancer by the insulin-like growth factors

1998 • 101 citations

Bisphosphonates in prostate carcinoma

1997 • 88 citations

A single nucleotide substitution introduces a premature termination codon into the androgen receptor gene of a patient with receptor-negative androgen resistance.

1990 • 81 citations

Bone Metastasis Model With Multiorgan Dissemination of Human Small-Cell Lung Cancer (SBC-5) Cells in Natural Killer Cell-Depleted SCID Mice

2001 • 79 citations

Effects of the Bisphosphonate Olpadronate in Patients With Carcinoma of the Prostate Metastatic to the Skeleton

1998 • 76 citations

Effects of endothelial cell growth factor on bone remodelling in vitro.

1987 • 75 citations

Heparin binding affinity of rat prostatic growth factor in normal and cancerous prostates: partial purification and characterization of rat prostatic growth factor in the Dunning tumor.

1987 • 71 citations

PTHrP(1–36) as a skeletal anabolic agent for the treatment of osteoporosis

1996 • 60 citations

Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases

2002 • 56 citations

Calcium Homeostasis: Hypercalcemia and Hypocalcemia

1990 • 53 citations

Calcium homeostasis : hypercalcemia and hypocalcemia

1989 • 51 citations

Use of bone turnover marker, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), in the assessment and monitoring of bone metastasis in prostate cancer

1999 • 42 citations

Serum concentration of type I collagen metabolites as a quantitative marker of bone metastases in patients with prostate carcinoma

1997 • 38 citations

Expression of the receptor for parathyroid hormone-related protein in normal and malignant breast tissue

1997 • 37 citations

Dissociation of bone formation markers in bone metastasis of prostate cancer

1997 • 36 citations

Human amniotic tumor that induces new bone formation in vivo produces growth-regulatory activity in vitro for osteoblasts identified as an extended form of basic fibroblast growth factor.

1996 • 32 citations

Ivory Vertebra

1998 • 4 citations

PTHrP, PARANEOPLASTIC SYNDROME AND CANCER METASTASIS

2001 • 1 citations