Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Efficacy and Safety of Trastuzumab as a Single Agent in First-Line Treatment of HER2-Overexpressing Metastatic Breast Cancer

2002 • 2,968 citations

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

1999 • 2,747 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Essential role for oncogenic Ras in tumour maintenance

1999 • 880 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

2002 • 639 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

2001 • 582 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting

2000 • 491 citations

Reversibility of acute B-cell leukaemia induced by BCR–ABL1

2000 • 412 citations

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

2001 • 408 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

Transgenic Polyoma middle-T mice model premalignant mammary disease.

2001 • 250 citations

The comparative pathology of human and mouse mammary glands.

1999 • 243 citations

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

1996 • 224 citations

A novel doxycycline‐inducible system for the transgenic analysis of mammary gland biology

2002 • 201 citations

Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer

2001 • 111 citations

Targeting HER2: Recent developments and future directions for breast cancer patients

2001 • 94 citations

Transgenic mouse models of mammary tumorigenesis.

1993 • 83 citations

Targeting HER2: Recent developments and future directions for breast cancer patients

2001 • 70 citations

HER2 overexpression and cancer targeting

2001 • 61 citations