??-1 Receptor Ligands

The Neuroendocrinology of Stress: A Never Ending Story

2008 • 3,415 citations

Neurobiology of Depression

2002 • 3,057 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1994 • 852 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Effects of estrogen on memory function in surgically menopausal women

1992 • 728 citations

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1998 • 658 citations

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

1998 • 598 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Neurosteroid metabolism in the human brain

2001 • 525 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Long-Term Synaptic Potentiation

1988 • 417 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Cloning and Functional Expression of the Human Type 1 Sigma Receptor (hSigmaR1)

1996 • 409 citations

Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex

2001 • 401 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit

2002 • 385 citations

Neurosteroids: Beginning of the story

2001 • 342 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Cognitive function in nondemented older women who took estrogen after menopause

1998 • 336 citations

Dehydroepiandrosterone (DHEA) treatment of depression

1997 • 317 citations

Regulating ankyrin dynamics: Roles of sigma-1 receptors

2001 • 305 citations

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors

1996 • 296 citations

Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

2003 • 291 citations

Cloning and Functional Characterization of a σ Receptor from Rat Brain

1998 • 288 citations

Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.

2000 • 287 citations

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

1998 • 280 citations

Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

2001 • 262 citations

Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression

1997 • 257 citations

σ-1 Receptors (σ₁Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export

2003 • 245 citations

Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain

1996 • 242 citations

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

1990 • 225 citations

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

2001 • 221 citations

Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands

1997 • 209 citations

Cocaine binding at σ receptors

1988 • 208 citations

Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens

2003 • 205 citations

Neurosteroids in depression: a review

2003 • 201 citations

Cloning and Structural Analysis of the cDNA and the Gene Encoding the Murine Type 1 Sigma Receptor

1997 • 199 citations

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

1983 • 187 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction

2003 • 182 citations

Intracellular Dynamics of σ-1 Receptors (σ₁Binding Sites) in NG108-15 Cells

2003 • 181 citations

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.

2001 • 178 citations

(+)-[3H]SKF 10,047, (+)-[3H]ethylketocyclazocine, μ, κ, δ and phencyclidine binding sites in guinea pig brain membranes

1985 • 168 citations

Sigma Receptors Inhibit High-Voltage–Activated Calcium Channels in Rat Sympathetic and Parasympathetic Neurons

2002 • 167 citations

Stereoisomers of N -Allylnormetazocine: Phencyclidine-Like Behavioral Effects in Squirrel Monkeys and Rats

1982 • 165 citations

σ-Receptors in Endocrine Organs: Identification, Characterization, and Autoradiographic Localization in Rat Pituitary, Adrenal, Testis, and Ovary

1989 • 158 citations

Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids

1985 • 153 citations

Selective antagonism of opioid analgesia by a sigma system.

1994 • 148 citations

Evidence for a multi-site model of the rat brain σ receptor

1989 • 144 citations

Synthesis and evaluation of optically pure [³H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

1989 • 141 citations

Sigma (σ1) receptor mediated antidepressant-like effects of neurosteroids in the Porsolt forced swim test

1998 • 138 citations

[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: Autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes

1997 • 135 citations

ς₁ Receptor Modulation of Opioid Analgesia in the Mouse

2002 • 128 citations

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via σ1-receptors

1997 • 125 citations

Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

1970 • 124 citations

Nerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves ς-1 Receptors: Implications for Antidepressants

2002 • 124 citations

PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

1994 • 123 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

1989 • 116 citations

Involvement of the Sigma1 Receptor in Cocaine-induced Conditioned Place Preference Possible Dependence on Dopamine Uptake Blockade

2002 • 115 citations

Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

1999 • 112 citations

Sigma‐1 and Sigma‐2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns

1994 • 112 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat

1989 • 108 citations

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides

2002 • 101 citations

σ Receptor antagonists block the development of sensitization to cocaine

1996 • 97 citations

Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss

1993 • 96 citations

Adrenal androgens and cortisol in major depression

1993 • 94 citations

Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity

1998 • 91 citations

Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons.

1995 • 87 citations

Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site

1995 • 87 citations

Neuropharmacology of St. John's Wort (Hypericum)

1998 • 82 citations

Enhanced κ-opioid receptor-mediated analgesia by antisense targeting the σ1 receptor

1997 • 80 citations

Dehydroepiandrosterone: Antiglucocorticoid Action in Mice

1992 • 79 citations

Modulation of serotonergic neurotransmission by short‐ and long‐term treatments with sigma ligands

2001 • 79 citations

Analysis of neurosteroid levels in attention deficit hyperactivity disorder

2001 • 75 citations

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

1990 • 72 citations

Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals σ receptor binding

1998 • 71 citations

Methamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia

1994 • 70 citations

Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia

1998 • 68 citations

Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)

1996 • 68 citations

Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor

1991 • 67 citations

N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice

2001 • 66 citations

Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.

2001 • 65 citations

Ameliorating effects of σ receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system

1994 • 65 citations

BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia

1994 • 63 citations

Involvement of σ1 receptors in methamphetamine-induced behavioral sensitization in rats

2000 • 58 citations

Decrease in σ but no increase in striatal dopamine D4 sites in schizophrenic brains

1996 • 58 citations

Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain.

1996 • 56 citations

ς₁Receptor Agonist-Mediated Regulation ofN-Methyl-d-aspartate-Stimulated [³H]Dopamine Release Is Dependent upon Protein Kinase C

2003 • 54 citations

Correlation between neuroleptic binding to σ1 and σ2 receptors and acute dystonic reactions

2000 • 53 citations

Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function.

1986 • 51 citations

Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced calcium signaling in rat primary neurons

1997 • 51 citations

Pentazocine and Tripelennamine: A Drug Abuse Epidemic?

1980 • 48 citations

Cocaine affects the dynamics of cytoskeletal proteins via sigma1 receptors

2001 • 48 citations

Sigma receptors in schizophrenic cerebral cortices

1992 • 45 citations

Effects of Hypericum perforatum Extract on Ethanol Intake, and on Behavioral Despair

2000 • 45 citations

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523

2001 • 45 citations

Persistent supersensitivity of σ receptors develops during repeated methamphetamine treatment

1992 • 44 citations

The antidepressant-like effect induced by the sigma1 (σ1) receptor agonist igmesine involves modulation of intracellular calcium mobilization

2002 • 40 citations

Strain differences in σ₁ receptor‐mediated behaviours are related to neurosteroid levels

2002 • 40 citations

Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

1999 • 39 citations

Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for σ receptors

1999 • 39 citations

NE‐100: A Novel Sigma Receptor Antagonist

1996 • 38 citations

Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors.

1992 • 38 citations

Open clinical trial on the sigma ligand panamesine in patients with schizophrenia

1997 • 38 citations

Phencyclidine and dizocilpine modulate dopamine release from rat nucleus accumbens via σ receptors

1999 • 34 citations

Efficacy and Safety of an Opiate Sigma-Receptor Antagonist (SL 82.0715) in Schizophrenic Patients with Negative Symptoms: an Open Dose-Range Study

1996 • 34 citations

σ receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP

1986 • 34 citations

Prevention of nimodipine-induced impairment of learning by the selective ? ligand PRE-084

1995 • 32 citations

Role of (+)-SKF-10,047-sensitive sub-population of σ1 receptors in amelioration of conditioned fear stress in rats: association with mesolimbic dopaminergic systems

1997 • 31 citations

Antidepressant drugs appear to enhance cocaine-induced toxicity.

2000 • 29 citations

MS-377, a novel selective σ1 receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain

2001 • 27 citations

Does sigma receptor antagonism predict clinical antipsychotic efficacy?

1991 • 25 citations

Antidepressant drugs appear to enhance cocaine-induced toxicity.

2000 • 25 citations

Repeated haloperidol treatment decreases σ1 receptor binding but does not affect its mRNA levels in the guinea pig or rat brain

2000 • 24 citations

Polymorphisms of the ?1 receptor gene in schizophrenia: An association study

2000 • 21 citations

Naloxone-sensitive, haloperidol-sensitive, [3H] (+) SKF-10047-binding protein partially purified from rat liver and rat brain membranes: An opioid/sigma receptor?

1997 • 21 citations

Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin‐releasing factor‐induced inhibition of gastric acid secretion in rats

1992 • 20 citations

Open label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics

1985 • 18 citations

Occupancy of striatal D 2 -like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic

1999 • 18 citations

Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial

1999 • 17 citations

Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose‐range study

1983 • 16 citations

Some of the effects of the selective sigma ligand (+)pentazocine are mediated via a naloxone-sensitive receptor

2001 • 15 citations

[Modulation of neuronal activities in the central nervous system via sigma receptors].

2002 • 13 citations

Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: Involvement of protein kinase

1999 • 13 citations

MS-377, a selective sigma receptor ligand, indirectly blocks the action of PCP in the N-methyl-D-aspartate receptor ion-channel complex in primary cultured rat neuronal cells

2002 • 13 citations

Ameliorating effects of sigma receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system.

1994 • 11 citations

Pentazocine psychosis: a case of persistent delusions.

1975 • 5 citations

Acute organic psychosis due to Talwin (pentazocine).

1970 • 5 citations

PILOT STUDIES ON THE EFFECT OF SL 82.0715 IN PSYCHOTIC SYNDROMES

1992 • 4 citations

Uncompetitive inhibition of [ ]1,3-di-o-tolyl-guanidine-defined σ binding sites by desipramine, propranolol and alprenolol in rat brain

1997 • 4 citations