NE‐100: A Novel Sigma Receptor Antagonist

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

1992 • 546 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Negative schizophrenic symptomatology and the PCP (phencyclidine) model of schizophrenia.

1987 • 238 citations

Novel antipsychotic drugs share high affinity for σ receptors

1988 • 206 citations

Sigma receptors in post-mortem human brains.

1988 • 169 citations

Developments in the drug treatment of schizophrenia

1992 • 154 citations

σ receptors

1991 • 148 citations

Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia

1991 • 148 citations

Receptor mechanisms in antipsychotic drug action: focus on sigma receptors

1989 • 138 citations

NE-100, a novel sigma receptor ligand: In vivo tests

1993 • 116 citations

Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine

1992 • 106 citations

NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain

1994 • 82 citations

Delayed regional metabolic actions of phencyclidine

1993 • 67 citations

BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia

1994 • 63 citations

Remoxipride

1990 • 54 citations

Excitatory amino acids: Implications for psychiatric disorders research

1994 • 48 citations

Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced delayed cognitive dysfunction in rats

1995 • 44 citations

Pharmacologic treatment of schizophrenia.

1991 • 43 citations

NE-100, a novel sigma receptor ligand: Effect on phencyclidine-induced behaviors in rats, dogs and monkeys

1994 • 39 citations

Effect of NE-100, a novel σ receptor ligand, on phencyclidine-induced cognitive dysfunction

1994 • 33 citations

A rat model of phencyclidine psychosis

1994 • 29 citations

Behavioural and electroencephalographic interactions between haloperidol and PCP/sigma ligands in the rat

1991 • 25 citations

Autoradiographic characterization of binding sites for [3H]NE-100 in guinea pig brain

1995 • 23 citations

Behavioral evidence for modulation by sigma ligands of (+)MK-801-induced hyperlocomotion in monoamine-depleted mice

1996 • 19 citations

Open label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics

1985 • 18 citations

Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors.

1986 • 17 citations

NE-100, a novel sigma ligand: effects on [3H]TCP binding to intact primary cultured neuronal cells

1995 • 15 citations

Interaction of sigma and PCP-like drugs on operant behaviors in the rat

1992 • 14 citations

NE-100, a novel sigma ligand: Effects on [3H]TCP binding to intact primary cultured neuronal cells

1994 • 12 citations

The sigma-selective ligand NE-100 attenuates the effect of phencyclidine in a rat diving model

1995 • 11 citations

Discriminative stimulus effects of the PCP/σ-ligand (+)-N-Allylnormetazocine in monkeys

1993 • 8 citations

Non-opioid antitussives potentiate some behavioural and EEG effects of N-methyl-D-aspartate channel blockers

1993 • 8 citations

Evidence for Distinct Phencyclidine and SKF10047 Receptors Following Detergent Treatment of Rat Brain Membranes

1992 • 5 citations