The antidepressant-like effect induced by the sigma1 (σ1) receptor agonist igmesine involves modulation of intracellular calcium mobilization

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Spatial and temporal aspects of cellular calcium signaling

1996 • 480 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Immunocytochemical localization of the sigma1 receptor in the adult rat central nervous system

2000 • 346 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Regulating ankyrin dynamics: Roles of sigma-1 receptors

2001 • 305 citations

Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.

2000 • 287 citations

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

1998 • 280 citations

The pharmacology of ryanodine and related compounds.

1997 • 266 citations

Caffeine inhibits inositol trisphosphate‐mediated liberation of intracellular calcium in Xenopus oocytes.

1991 • 215 citations

Neuroactive Neurosteroids as Endogenous Effectors for the Sigma1 (.SIGMA.1) Receptor. Pharmacological Evidence and Therapeutic Opportunities.

1999 • 181 citations

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.

2001 • 178 citations

Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain

1988 • 176 citations

In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.

1992 • 173 citations

Exon‐Intron Structure, Analysis of Promoter Region, and Chromosomal Localization of the Human Type 1 σ Receptor Gene

1998 • 161 citations

Sigma (σ1) receptor mediated antidepressant-like effects of neurosteroids in the Porsolt forced swim test

1998 • 138 citations

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via σ1-receptors

1997 • 125 citations

σ1 Receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test

1996 • 119 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

1989 • 116 citations

Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.

1994 • 116 citations

Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors.

1996 • 114 citations

The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (σ1) receptors

1998 • 108 citations

Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes.

1994 • 106 citations

Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to ?1 receptors in the mouse forebrain

1996 • 97 citations

Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy

2000 • 97 citations

Modulation by sigma ligands of intracellular free Ca++ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons.

1995 • 87 citations

JO 1784, a potent and selective ligand for rat and mouse brain σ-sites

1990 • 77 citations

Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency

1992 • 70 citations

Beneficial effects of sigma agonists on the age-related learning impairment in the senescence-accelerated mouse (SAM)

1996 • 68 citations

Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor

1991 • 67 citations

Highly selective σ receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes

1998 • 66 citations

JO1784, a novel σ ligand, potentiates [3H]acetylcholine release from rat hippocampal slices

1991 • 64 citations

Neurosteroids Ameliorate Conditioned Fear Stress An Association with Sigma1 Receptors

2000 • 56 citations

Behavioral sensitization to cocaine after a brief social stress is accompanied by changes in Fos expression in the murine brainstem

1998 • 55 citations

Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ₁ receptor‐mediated behaviour in mice

1999 • 51 citations

Involvement of σ receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems

1999 • 50 citations

σ1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism

1995 • 47 citations

Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat

1989 • 45 citations

The Biphasic Effects of Centrally and Peripherally Administered Caffeine on Ethanol-induced Motor Incoordination in Mice

1988 • 44 citations

Relationship between Sigma-like site and progesterone-binding site of adult male rat liver microsomes

1994 • 40 citations

Opposite central cardiovascular effects of nifedipine and BAY k 8644 in anesthetized rats.

1987 • 39 citations

Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors.

1992 • 38 citations

Up-regulation of sigma1 receptor mRNA in rat brain by a putative atypical antipsychotic and sigma receptor ligand

2000 • 38 citations

Involvement of Intracellular Calcium in Morphine Tolerance in Mice

1999 • 38 citations

Protein Phosphorylation and Calcium Uptake into Rat Forebrain Synaptosomes: Modulation by the σ Ligand, 1,3‐Ditolylguanidine

1997 • 37 citations

Regulation of NMDA-induced [3H] dopamine release from rat hippocampal slices through sigma-1 binding sites

1998 • 36 citations

Release of norepinephrine and dopamine from brain vesicular preparations: Effects of calcium antagonists

1982 • 34 citations

Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium.

1995 • 34 citations

Prevention of nimodipine-induced impairment of learning by the selective ? ligand PRE-084

1995 • 32 citations

Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant

2001 • 31 citations

Distribution of excitatory and inhibitory amino acid, sigma, monoamine, catecholamine, acetylcholine, opioid, neurotensin, substance P, adenosine and neuropeptide Y receptors in human motor and somatosensory cortex

1991 • 26 citations

Autoradiographic characterization of binding sites for [3H]NE-100 in guinea pig brain

1995 • 23 citations

Autoradiographic evidence for the modulation of in vivo sigma receptor labeling by neuropeptide Y and calcitonin gene-related peptide in the mouse brain.

1996 • 22 citations

Sympathoinhibition by Central and Peripheral Infusion of Nifedipine in Spontaneously Hypertensive Rats

2000 • 22 citations

Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin‐releasing factor‐induced inhibition of gastric acid secretion in rats

1992 • 20 citations

Influence of ω-conotoxin on morphine analgesia and withdrawal syndrome in rats

1992 • 19 citations

The differential effects of calcium channel blockers in the behavioural despair test in mice

2000 • 18 citations

Integrated autonomic and behavioral responses to L/N Ca2(+)-channel blocker omega-conotoxin in conscious rats

1990 • 17 citations

Distribution of N-type Ca2+ channel binding sites in rabbit brain following central administration of ω-conotoxin GVIA

1996 • 16 citations

Repeated administration of Sigma ligands alters the population activity of rat midbrain dopaminergic neurons

1993 • 15 citations

Effect of Chronic Pretreatment with the Sigma Ligand JO 1784 on CRF-lnduced Changes in Behaviour, Neurotransmitter and Immunological Function in the Rat

1997 • 14 citations

Reversal of CRF‐ and dopamine‐induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat

1994 • 12 citations

Differential effects of omega-conotoxin GVIA, nimodipine, calmidazolium and KN-62 injected intrathecally on the antinociception induced by beta-endorphin, morphine and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin administered intracerebroventricularly in the mouse.

1997 • 11 citations

Influences of Verapamil, X-537A, A-23187 and Adenosine 3’, 5’-Cyclic Monophosphate on Release of 5-Hydroxytryptamine from Rat Brain Slices

1978 • 11 citations

IP3 receptor antagonist heparin uncompetitively inhibits [3H](+)-SKF-10047 binding to σ receptors

1996 • 9 citations

Effect of nifedipine and verapamil on hypotensive action of clonidine in rabbits.

1998 • 2 citations