Sigma‐1 and Sigma‐2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

Sigma receptors: biology and function.

1990 • 799 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

1990 • 376 citations

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

1990 • 225 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.

1992 • 173 citations

σ receptors

1991 • 148 citations

Evidence for a multi-site model of the rat brain σ receptor

1989 • 144 citations

Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.

1991 • 111 citations

σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain

1988 • 111 citations

σ Receptors: From Molecule to Man

1991 • 102 citations

Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders

1990 • 99 citations

Drug specificity of pharmacological dystonia

1990 • 97 citations

Selective σ ligands block stimulant effects of cocaine

1991 • 95 citations

Regulation of σ‐Receptors: High‐ and Low‐Affinity Agonist States, GTP Shifts, and Up‐Regulation by Rimcazole and 1,3‐Di(2‐Tolyl)guanidine

1989 • 90 citations

Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.

1989 • 85 citations

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin

1989 • 75 citations

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

1990 • 72 citations

Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor.

1991 • 68 citations

[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct σ binding sites in guinea pig brain membranes

1991 • 66 citations

Guinea-pig vas deferens preparation may contain both receptors and phencyclidine receptors

1987 • 51 citations

Phencyclidine/SKF-10,047 binding sites: Evaluation of function

1989 • 50 citations

Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil

1991 • 49 citations

Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain

1991 • 49 citations

Antagonist drug selectivity for radioligand binding sites on voltage-gated and receptor-gated Ca2+ channels

1989 • 41 citations

Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions

1988 • 31 citations

BMY-14802 protects against ischemia-induced neuronal damage in the gerbil

1992 • 30 citations

Divergent ontogeny of sigma and phencyclidine binding sites in the rat brain

1989 • 28 citations

(+) 3-[3-Hydroxyphenyl-n-(1-propyl) piperidine] selectively differentiates effects of sigma ligands on neurochemical pathways modulated by sigma receptors: Evidence for subtypes, in vivo

1991 • 26 citations

Pharmacological studies with isolated cell components

1962 • 24 citations

Haloperidol competitively inhibits the binding of (+)-[3H]SKF-10,047 to σ sites

1990 • 22 citations

DIFFERENCES IN THE SUBCELLULAR AND SUBSYNAPTOSOMAL DISTRIBUTION OF THE PUTATIVE ENDOPLASMIC RETICULUM MARKERS, NADPH‐CYTOCHROME c REDUCTASE, ESTRONE SULFATE SULFOHYDROLASE AND CDP‐CHOLINE DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE IN RAT BRAIN

1979 • 22 citations

Transduction of a discriminative stimulus through a diazepam-insensitive gamma-aminobutyric acidA receptor.

1993 • 20 citations

Sigma ligand-induced emesis in the pigeon

1992 • 18 citations