Correlation between neuroleptic binding to σ1 and σ2 receptors and acute dystonic reactions

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Sigma receptors: biology and function.

1990 • 799 citations

A Survey of Drug-Induced Extrapyramidal Reactions

1961 • 756 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

1984 • 348 citations

Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism

1995 • 253 citations

Cocaine binding at σ receptors

1988 • 208 citations

Cloning and Structural Analysis of the cDNA and the Gene Encoding the Murine Type 1 Sigma Receptor

1997 • 199 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain

1988 • 176 citations

The neurobiology of attention-deficit/hyperactivity disorder.

1998 • 175 citations

A single-blind comparison of intravenous ondansetron, a selective serotonin antagonist, with intravenous metoclopramide in the prevention of nausea and vomiting associated with high-dose cisplatin chemotherapy.

1991 • 152 citations

Cloning and Characterization of a Mouse σ₁ Receptor

1998 • 149 citations

Metabolites of haloperidol display preferential activity at σ receptors compared to dopamine D-2 receptors

1990 • 149 citations

Drug-induced dystonia

1975 • 142 citations

[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: Autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes

1997 • 135 citations

Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity

1999 • 112 citations

Drug specificity of pharmacological dystonia

1990 • 97 citations

Extrapyramidal side effects of clozapine and haloperidol

1995 • 93 citations

Molindone hydrochloride treatment of hospitalized children with conduct disorder.

1985 • 90 citations

The role of pimozide in clinical psychiatry: a review.

1991 • 83 citations

A comparison of (−)-deoxybenzomorphans devoid of opiate activity with their dextrorotatory phenolic counterparts suggests role of σ2 receptors in motor function

1993 • 82 citations

Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine

1999 • 80 citations

Incidence and correlates of acute extrapyramidal symptoms in first episode of schizophrenia.

1992 • 78 citations

Clinical Evaluation of Sulpiride in Schizophrenic Patients ‐ A Double‐blind Comparison with Chlorpromazine

1984 • 78 citations

Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons

1989 • 75 citations

Different side effect profiles of risperidone and clozapine in 20 outpatients with schizophrenia or schizoaffective disorder: a pilot study

1996 • 74 citations

Sulpiride and Haloperidol in Schizophrenia: A Double-blind Cross-over Study of Therapeutic Effect, Side Effects and Plasma Concentrations

1985 • 71 citations

Cocaine as a Risk Factor for Neuroleptic-Induced Acute Dystonia

1998 • 67 citations

Increase in rat striatal extracellular dopamine and vacous chewing produced by two σ receptor ligands

1993 • 65 citations

Use of neuroleptic-induced extrapyramidal symptoms to predict future vulnerability to side effects

1991 • 62 citations

Controlled Trial of Sulpiride in Chronic Schizophrenic Patients

1980 • 61 citations

Drug-induced dystonia in young and elderly patients

1988 • 58 citations

Adverse effects of the atypical antipsychotics

1998 • 56 citations

Effects of σ receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat

1995 • 51 citations

Cocaine as a risk factor for acute dystonic reactions

1991 • 51 citations

Anticholinergic agents for prophylaxis of neuroleptic-induced dystonic reactions: a prospective study.

1986 • 44 citations

The effect of benztropine on haloperidol-induced dystonia, clinical efficacy and pharmacokinetics: a prospective, double-blind trial.

1991 • 37 citations

Neuroleptic binding to sigma receptors: Possible involvement in neuroleptic-induced acute dystonia

1997 • 36 citations

Inhibition of rubral neurons by noxious and non-noxious pressure

1991 • 31 citations

The Australian multicentre double‐blind comparative study of remoxipride and thioridazine in schizophrenia

1994 • 29 citations

Prevalence of neuroleptic-induced dystonia in mania and schizophrenia

1990 • 27 citations

Pharmacological Characteristics and Distributions of σ and Phencyclidine Receptors in the Animal Kingdom

1990 • 24 citations

Pimozide in the treatment of chronic schizophrenic patients.

1970 • 24 citations

The relationship of dopamine receptor blockade to clinical response in schizophrenic patients treated with pimozide or haloperidol

1984 • 23 citations

Sulpiride: evaluation of antipsychotic activity in schizophrenic patients.

1977 • 23 citations

Mood Alteration Following Oral and Intravenous Haloperidol and Relationship to Drug Concentration in Normal Subjects

1985 • 21 citations

Age-related differences in the sensitivity of rats to a selective sigma ligand

1989 • 21 citations

Chlorpromazine with and without lorazepam as antiemetic therapy in children receiving uniform chemotherapy

1993 • 21 citations

Effects of age and strain differences on the red nucleus of the mouse mutant Dystonia musculorum

1983 • 18 citations

A comparison of the clinical effects of bromperidol, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique.

1985 • 17 citations

High-Dose Oral and Intravenous Metoclopramide in Doxorubicin/Cyclophosphamide-Induced Emesis A Randomized Double-Blind Study

1987 • 17 citations

Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats

1998 • 15 citations

Brain stem pathology in cranial dystonia.

1988 • 14 citations

Pharmacological comparison of the sigma recognition site labelled by [3H]haloperidol in human and rat cerebellum

1992 • 14 citations

A double‐blind comparison of raclopride and haloperidol in the acute phase of schizophrenia

1992 • 13 citations

Metoclopramide as an Antiemetic Agent in Pediatric Oncology Patients

1986 • 12 citations

σ Binding parameters in developing rats predict behavioral efficacy of a σ ligand

1993 • 11 citations

Long-acting, antipsychotic agents and extrapyramidal side effects.

1970 • 8 citations

Betamethasone-Dixyrazine Versus Metoclopramide as Antiemetic Treatment in Cancer Chemotherapy

1988 • 4 citations