The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Tmbase-A database of membrane spanning protein segments

1993 • 2,294 citations

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1998 • 2,076 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

1994 • 845 citations

G protein-coupled mechanisms and nervous signaling

1992 • 474 citations

Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors

2000 • 437 citations

Cloning and Functional Expression of the Human Type 1 Sigma Receptor (hSigmaR1)

1996 • 409 citations

Ion channel regulation by G proteins

1995 • 408 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

Presynaptic A-current based on heteromultimeric K+ channels detected in vivo

1993 • 379 citations

Regulating ankyrin dynamics: Roles of sigma-1 receptors

2001 • 305 citations

Structure of a Voltage-Dependent K+ Channel β Subunit

1999 • 281 citations

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

1997 • 225 citations

Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation.

1996 • 206 citations

Regulation of potassium channels by protein kinases

1996 • 201 citations

Cloning and Structural Analysis of the cDNA and the Gene Encoding the Murine Type 1 Sigma Receptor

1997 • 199 citations

A three-state receptor model of agonist action

1997 • 192 citations

Functional and Molecular Aspects of Voltage‐Gated K⁺ Channel β Subunits

1999 • 192 citations

Phenotypic Alteration of a Human BK (hSlo) Channel byhSloβSubunit Coexpression: Changes in Blocker Sensitivity, Activation/Relaxation and Inactivation Kinetics, and Protein Kinase A Modulation

1996 • 182 citations

Intracellular σ ₁ receptor modulates phospholipase C and protein kinase C activities in the brainstem

1999 • 166 citations

Kvβ1.2 Subunit Coexpression in HEK293 Cells Confers O2 Sensitivity to Kv4.2 but not to Shaker Channels

1999 • 157 citations

Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library

1990 • 149 citations

Estrogen induction of a small, putative K+ channel mRNA in rat uterus

1990 • 118 citations

Membrane‐delimited coupling between sigma receptors and K⁺ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP

2000 • 110 citations

Three potassium channels in rat posterior pituitary nerve terminals.

1992 • 104 citations

Delineating biochemical and functional properties of sigma receptors: emerging concepts.

1993 • 99 citations

Differential Asparagine-Linked Glycosylation of Voltage-Gated K + Channels in Mammalian Brain and in Transfected Cells

1999 • 81 citations

Sigma Receptor Photolabeling and Sigma Receptor-mediated Modulation of Potassium Channels in Tumor Cells

1999 • 68 citations

Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia

1998 • 68 citations

Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology.

1994 • 64 citations

Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding

1999 • 64 citations

K⁺ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors

1999 • 62 citations

A three-state receptor model of agonist action

1997 • 58 citations

(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor.

1992 • 53 citations

A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway.

1999 • 50 citations

Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances.

1998 • 45 citations

A GABAA Receptor α1 Subunit Tagged with Green Fluorescent Protein Requires a β Subunit for Functional Surface Expression

1998 • 38 citations

Proteins that interact with the pore-forming subunits of voltage-gated ion channels

1995 • 34 citations

Molecular biology approaches to comparative study of Na(+)-glucose cotransport

1992 • 26 citations

Characterization of the currents induced by sigma ligands in NCB20 neuroblastoma cells

1994 • 20 citations