Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Neurosteroids: Biosynthesis and Function of These Novel Neuromodulators

2000 • 807 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.

1990 • 615 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

1994 • 423 citations

Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells.

1990 • 340 citations

Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism

1995 • 253 citations

Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.

1993 • 215 citations

Binding properties of SA4503, a novel and selective σ1 receptor agonist

1996 • 186 citations

Neuroactive Neurosteroids as Endogenous Effectors for the Sigma1 (.SIGMA.1) Receptor. Pharmacological Evidence and Therapeutic Opportunities.

1999 • 181 citations

Intracellular σ ₁ receptor modulates phospholipase C and protein kinase C activities in the brainstem

1999 • 166 citations

Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly

2000 • 130 citations

Progesterone and estrogens in rat brain: Modulation of GABA (γ-aminobutyric acid) receptor activity

1984 • 115 citations

Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis

1999 • 110 citations

Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice

1998 • 109 citations

Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord.

1999 • 94 citations

Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency

1992 • 70 citations

The effects of sigma ligands and of neuropeptide Y on N‐methyl‐<scp>d</scp>‐aspartate‐induced neuronal activation of CA₃ dorsal hippocampus neurones are differentially affected by pertussin toxin

1994 • 65 citations

Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding

1999 • 64 citations

CB-64D and CB-184: ligands with high σ2 receptor affinity and subtype selectivity

1995 • 58 citations

Neurosteroids: From Definition and Biochemistry to Physiopathologic Function

1999 • 53 citations

Regulation of σ receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple σ binding sites

1991 • 50 citations

Protein kinase C-mediated acute tolerance to peripheral mu-opioid analgesia in the bradykinin-nociception test in mice.

2000 • 50 citations

Neurosteroids stimulate G protein-coupled sigma receptors in mouse brain synaptic membrane

2001 • 47 citations

In Vivo Molecular Signal Transduction of Peripheral Mechanisms of Pain

1999 • 41 citations

In vivo signal transduction of nociceptive response by kyotorphin (tyrosine-arginine) through Galpha(i)- and inositol trisphosphate-mediated Ca(2+) influx.

2000 • 39 citations

Complete inhibition of purinoceptor agonist-induced nociception by spinorphin, but not by morphine

2000 • 37 citations

Modulation of Ionotropic Glutamate Receptors by Neuroactive Steroids

1999 • 34 citations

Inositol 1,4,5-Trisphosphate-Gated Calcium Transport through Plasma Membranes in Nerve Terminals

1996 • 32 citations

Localization of Type I Inositol 1,4,5-Triphosphate Receptor in the Outer Segments of Mammalian Cones

1999 • 28 citations

Activation of Gi1by Lysophosphatidic Acid Receptor without Ligand in the Baculovirus Expression System

1999 • 28 citations

Selective coupling of mouse brain metabotropic sigma (σ) receptor with recombinant Gi1

1999 • 20 citations

Steroid Modulation of the Nicotinic Acetylcholine Receptor

1999 • 16 citations

Neurosteroid Antagonists of the GABAA Receptors

1999 • 12 citations

Evidence for presynaptic plasma membrane IP3 receptor involved in C-fiber nociception mechanisms

2000 • 1 citations