[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: Autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

Sigma receptors: biology and function.

1990 • 799 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.

1976 • 467 citations

Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

1994 • 423 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

1990 • 376 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.

1981 • 254 citations

Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism

1995 • 253 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

Behavioral evidence for a modulating role of σ ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia

1994 • 211 citations

Cocaine binding at σ receptors

1988 • 208 citations

Novel antipsychotic drugs share high affinity for σ receptors

1988 • 206 citations

Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain

1988 • 176 citations

Sigma receptors in post-mortem human brains.

1988 • 169 citations

σ receptors

1991 • 148 citations

Selective antagonism of opioid analgesia by a sigma system.

1994 • 148 citations

Synthesis and evaluation of optically pure [³H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

1989 • 141 citations

Receptor mechanisms in antipsychotic drug action: focus on sigma receptors

1989 • 138 citations

PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice

1994 • 123 citations

Endogenous ligands for sigma opioid receptors in the brain (“sigmaphin”): Evidence from binding assays

1986 • 117 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

1989 • 116 citations

Sigma‐1 and Sigma‐2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns

1994 • 112 citations

Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.

1991 • 111 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat

1989 • 108 citations

An endogenous ligand for the sigma opioid binding site

1987 • 102 citations

σ Receptors: From Molecule to Man

1991 • 102 citations

Characterization and autoradiographic visualization of (+)-[3H]SKF10,047 binding in rat and mouse brain: further evidence for phencyclidine/"sigma opiate" receptor commonality.

1986 • 101 citations

Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders

1990 • 99 citations

Delineating biochemical and functional properties of sigma receptors: emerging concepts.

1993 • 99 citations

Drug specificity of pharmacological dystonia

1990 • 97 citations

Selective σ ligands block stimulant effects of cocaine

1991 • 95 citations

Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain

1987 • 92 citations

Differential regulation of σ and PCP receptors after chronic administration of haloperidol and phencyclidine in mice

1989 • 91 citations

Alterations in phencyclidine and sigma binding sites in schizophrenic brains

1991 • 90 citations

Regulation of σ‐Receptors: High‐ and Low‐Affinity Agonist States, GTP Shifts, and Up‐Regulation by Rimcazole and 1,3‐Di(2‐Tolyl)guanidine

1989 • 90 citations

Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.

1989 • 85 citations

The sigma receptor: a novel site implicated in psychosis and antipsychotic drug efficacy.

1988 • 83 citations

Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.

1989 • 82 citations

Narcotic Antagonists as Analgesics

1964 • 78 citations

Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study

1992 • 76 citations

The Sigma Receptor

1988 • 76 citations

Binding of sigma-ligands to C57BL/6 mouse brain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of sigma-receptor subtypes.

1991 • 72 citations

Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.

1984 • 71 citations

Modification of the N-methyl-D-aspartate response by antidepressant σ receptor ligands

1993 • 68 citations

Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor

1991 • 67 citations

Sigma receptors are associated with cortical limbic areas in the primate brain

1992 • 65 citations

The effects of sigma ligands and of neuropeptide Y on N‐methyl‐<scp>d</scp>‐aspartate‐induced neuronal activation of CA₃ dorsal hippocampus neurones are differentially affected by pertussin toxin

1994 • 65 citations

Ameliorating effects of σ receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system

1994 • 65 citations

Regional variation in the ratio of σ1 to σ2 binding in rat brain

1994 • 62 citations

Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents

1991 • 62 citations

Drugs Acting on σ and Phencyclidine Receptors

1989 • 61 citations

[3H](+)-Pentazocine binding to rat brain σ1 receptors

1994 • 58 citations

[3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.

1993 • 55 citations

(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor.

1992 • 53 citations

Behavioral evidence for a modulating role of σ ligands in memory processes. II. Reversion of carbon monoxide-induced amnesia

1994 • 50 citations

Regulation of σ receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple σ binding sites

1991 • 50 citations

Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil

1991 • 49 citations

High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions.

1988 • 49 citations

The psychotomimetic effects of opiates and the sigma receptor.

1990 • 47 citations

Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.

1993 • 44 citations

Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine.

1988 • 42 citations

Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain.

1992 • 42 citations

The sigma enigma: biochemical and functional correlates emerge for the haloperidol-sensitive sigma binding site

1990 • 40 citations

Multiple σ binding sites in guinea‐pig and rat brain membranes: G‐protein interactions

1992 • 38 citations

Resiniferatoxin and piperine: Capsaicin-like stimulators of oxygen uptake in the perfused rat hindlimb

1994 • 33 citations

σ and PCP receptors in human frontal cortex membranes

1988 • 32 citations

Modulation of (+)-[3H]pentazocine binding to guinea pig cerebellum by divalent cations.

1992 • 31 citations

Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions

1988 • 31 citations

BMY-14802 protects against ischemia-induced neuronal damage in the gerbil

1992 • 30 citations

[3H]Ditolylguanidine binding to human brain σ sites is diminished after haloperidol treatment

1991 • 29 citations

In vivo binding of [3H]d-N-allylnormetazocine and [3H]haloperidol to sigma receptors in the mouse brain.

1990 • 29 citations

Down-regulation of sigma receptors by chronic haloperidol.

1990 • 25 citations

Solubilization and Characterization of ?-Receptors from Guinea Pig Brain Membranes

1989 • 22 citations

Pharmacological characterization of in vivo [3H]lfenprodil binding sites in the mouse brain.

1992 • 22 citations

Autoradiographic evidence for the modulation of in vivo sigma receptor labeling by neuropeptide Y and calcitonin gene-related peptide in the mouse brain.

1996 • 22 citations

Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain

1995 • 20 citations

Iontophoretic effects of sigma ligands on rubral neurons in the rat

1992 • 19 citations

[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity

1987 • 19 citations

[3H]-(+)-pentazocine binding to sigma recognition sites in human cerebellum

1994 • 19 citations

Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor

1991 • 18 citations

Labeling in vivo of sigma receptors in mouse brain with [³H]‐(+)‐SKF 10,047: Effects of phencyclidine, (+)‐ and (−)‐N‐allylnormetazocine, and other drugs

1991 • 1 citations