Low-dose Chemotherapeutic Agents Regulate Small Rho GTPase Activity in Dendritic Cells

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

RHO–GTPases and cancer

2002 • 1,355 citations

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

2005 • 1,330 citations

Dendritic cells as therapeutic vaccines against cancer

2005 • 1,195 citations

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

2007 • 728 citations

Immunotherapy and chemotherapy — a practical partnership

2005 • 639 citations

Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

2001 • 541 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

2007 • 531 citations

Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

2003 • 441 citations

The Small GTPase Rho: Cellular Functions and Signal Transduction

1996 • 404 citations

Masquerader: High Mobility Group Box-1 and Cancer

2007 • 358 citations

Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation

2000 • 275 citations

Requirement of Rac1 and Rac2 Expression by Mature Dendritic Cells for T Cell Priming

2004 • 225 citations

Function and regulation of Rnd proteins

2006 • 211 citations

Comparative analysis of necrotic and apoptotic tumor cells as a source of antigen(s) in dendritic cell-based immunization.

2001 • 202 citations

Leveraging the Activity of Tumor Vaccines with Cytotoxic Chemotherapy

2005 • 180 citations

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

2001 • 160 citations

Opposite Effects of Rho Family GTPases on Engulfment of Apoptotic Cells by Macrophages

2006 • 148 citations

Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling

2003 • 146 citations

Rho GDP Dissociation Inhibitor Protects Cancer Cells against Drug-Induced Apoptosis

2005 • 135 citations

Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine

2007 • 134 citations

Low-Dose Paclitaxel Prior to Intratumoral Dendritic Cell Vaccine Modulates Intratumoral Cytokine Network and Lung Cancer Growth

2007 • 126 citations

High Mobility Group Box I (HMGB1) Release From Tumor Cells After Treatment: Implications for Development of Targeted Chemoimmunotherapy

2007 • 124 citations

Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.

2001 • 122 citations

RhoE Inhibits Cell Cycle Progression and Ras-Induced Transformation

2004 • 115 citations

Determinant spreading and tumor responses after peptide-based cancer immunotherapy

2003 • 110 citations

Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases

2002 • 94 citations

Combined chemoimmunotherapy of solid tumours: Improving vaccines?

2006 • 94 citations

Rho GTPases and cell cycle control

2006 • 84 citations

Dendritic cell-based vaccination combined with gemcitabine increases survival in a murine pancreatic carcinoma model

2007 • 84 citations

Recovery of CD8+ T-Cell Function During Systemic Chemotherapy in Advanced Ovarian Cancer

2005 • 82 citations

A Pivotal Role of Rho GTPase in the Regulation of Morphology and Function of Dendritic Cells

2001 • 80 citations

Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference

2007 • 77 citations

Small Rho GTPases Regulate Antigen Presentation in Dendritic Cells

2005 • 74 citations

Function and regulation of RhoE

2005 • 74 citations

Drug- and cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells

2003 • 69 citations

Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma

2007 • 61 citations

Cell Migration and Signaling Specificity Is Determined by the Phosphatidylserine Recognition Motif of Rac1

2006 • 59 citations

Influence of drug‐induced apoptotic death on processing and presentation of tumor antigens by dendritic cells

2003 • 59 citations

The influence on the immunomodulatory effects of dying and dead cells of Annexin V

2006 • 51 citations

Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo

2004 • 48 citations

Apoptotic, necrotic, or fused tumor cells: An equivalent source of antigen for dendritic cell loading

2006 • 46 citations

Rho GTPases Are Involved in the Regulation of NF-κB by Genotoxic Stress

2001 • 44 citations

Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model

2007 • 37 citations

The Protective Role of a Small GTPase RhoE against UVB-induced DNA Damage in Keratinocytes

2006 • 37 citations

Small Rho GTPases Mediate Tumor-Induced Inhibition of Endocytic Activity of Dendritic Cells

2007 • 36 citations

Optimizing dendritic cell-based immunotherapy for cancer

2007 • 32 citations

Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5

2007 • 30 citations

RhoE participates in the stimulation of the inflammatory response induced by ethanol in astrocytes

2007 • 30 citations

Protective specific immunity induced by doxorubicin plus TNF-α combination treatment of EL4 lymphoma-bearing C57BL/6 mice

2000 • 27 citations

Dendritic Cell–Dead Cell Interactions: Implications and Relevance for Immunotherapy

2001 • 24 citations

Antigen loading of dendritic cells with apoptotic tumor cell-preparations is superior to that using necrotic cells or tumor lysates.

2007 • 22 citations

Inhibition of ROCK by RhoE

2006 • 14 citations