Masquerader: High Mobility Group Box-1 and Cancer

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

The inflammatory reflex

2002 • 3,274 citations

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

2005 • 2,372 citations

RAGE Mediates a Novel Proinflammatory Axis

1999 • 1,807 citations

Understanding RAGE, the receptor for advanced glycation end products

2005 • 1,221 citations

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

2003 • 1,200 citations

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

2000 • 1,200 citations

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

2004 • 1,130 citations

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

1995 • 1,116 citations

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

2003 • 1,105 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

Intracellular and extracellular roles of S100 proteins

2003 • 963 citations

The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway

2002 • 890 citations

Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-κB

2001 • 801 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids

1973 • 757 citations

Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells

2003 • 721 citations

Receptor for Advanced Glycation End Products (RAGE)-mediated Neurite Outgrowth and Activation of NF-κB Require the Cytoplasmic Domain of the Receptor but Different Downstream Signaling Pathways

1999 • 621 citations

Alkylating DNA damage stimulates a regulated form of necrotic cell death

2004 • 618 citations

HMG1 and 2, and related ‘architectural’ DNA-binding proteins

2001 • 609 citations

Response to comment on: “A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production” by Heyer et al. [Toxicol. Lett. 161 (2006) 159–166]

2006 • 598 citations

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

2002 • 589 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

The cytokine activity of HMGB1

2005 • 529 citations

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

1999 • 523 citations

The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

2005 • 512 citations

Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products

2005 • 498 citations

RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages

2005 • 485 citations

Structural features of the HMG chromosomal proteins and their genes

1990 • 474 citations

Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation

2004 • 462 citations

NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

1998 • 454 citations

The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

2001 • 454 citations

The vagus nerve and the nicotinic anti-inflammatory pathway

2005 • 450 citations

High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization

2004 • 435 citations

Activation of gene expression in human neutrophils by high mobility group box 1 protein

2003 • 423 citations

Structure of the HMG box motif in the B-domain of HMG1.

1993 • 403 citations

Role of HMGB1 in apoptosis-mediated sepsis lethality

2006 • 378 citations

Mini‐review: The nuclear protein HMGB1 as a proinflammatory mediator

2004 • 369 citations

Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells

2005 • 356 citations

Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function

2004 • 351 citations

Structural Basis for the Proinflammatory Cytokine Activity of High Mobility Group Box 1

2003 • 343 citations

HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

1994 • 343 citations

High-mobility group box 1 (HMGB1) protein: Friend and foe

2006 • 336 citations

Ancestry and diversity of the HMG box superfamily

1993 • 328 citations

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

1993 • 327 citations

High mobility group 1 B‐box mediates activation of human endothelium

2003 • 321 citations

NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1

2005 • 319 citations

Successful treatment of collagen‐induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

2003 • 316 citations

Therapeutic effects of lysophosphatidylcholine in experimental sepsis

2004 • 309 citations

Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis.

2002 • 284 citations

Alarmin(g) news about danger

2006 • 272 citations

S100P Stimulates Cell Proliferation and Survival via Receptor for Activated Glycation End Products (RAGE)

2004 • 266 citations

Synthesis, Characterization, and Cytotoxicity of a Series of Estrogen-Tethered Platinum(IV) Complexes

2004 • 253 citations

ELEVATED HIGH-MOBILITY GROUP BOX 1 LEVELS IN PATIENTS WITH CEREBRAL AND MYOCARDIAL ISCHEMIA

2006 • 251 citations

Regulation of monocyte migration by amphoterin (HMGB1)

2004 • 249 citations

30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane.

1991 • 241 citations

Three Genes in the Human MHC Class III Region near the Junction with the Class II: Gene for Receptor of Advanced Glycosylation End Products, PBX2 Homeobox Gene and a Notch Homolog, Human Counterpart of Mouse Mammary Tumor Gene int-3

1994 • 234 citations

Cutting Edge: Extracellular High Mobility Group Box-1 Protein Is a Proangiogenic Cytokine

2006 • 227 citations

Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.

1993 • 218 citations

Purification and Characterization of Mouse Soluble Receptor for Advanced Glycation End Products (sRAGE)

2004 • 215 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development

2005 • 203 citations

HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma

2003 • 191 citations

Innate Immunity and Angiogenesis

2005 • 190 citations

High Affinity Binding and Overlapping Localization of Neurocan and Phosphacan/Protein-tyrosine Phosphatase-ζ/β with Tenascin-R, Amphoterin, and the Heparin-binding Growth-associated Molecule

1998 • 189 citations

A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1

1989 • 188 citations

HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and p73-dependent Sequence-specific Transactivation from the Human Bax Gene Promoter

2002 • 183 citations

Regulation of cell migration by amphoterin

2000 • 164 citations

Reduction in Surface Urokinase Receptor Forces Malignant Cells into a Protracted State of Dormancy

1997 • 158 citations

Addicted to Death

2004 • 157 citations

Studies of acetylation and deacetylation in high mobility group proteins. Identification of the sites of acetylation in HMG-1.

1979 • 154 citations

Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas

2005 • 152 citations

Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility

2000 • 152 citations

Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma

2004 • 148 citations

Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.

1991 • 142 citations

Antibodies against chromosomal HMG proteins stain the cytoplasm of mammalian cells

1979 • 139 citations

HMGB-1 AS A THERAPEUTIC TARGET FOR INFECTIOUS AND INFLAMMATORY DISORDERS

2005 • 137 citations

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair

2004 • 132 citations

Differential effects between amphoterin and advanced glycation end products on colon cancer cells

2003 • 131 citations

Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas

2005 • 119 citations

Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis

2005 • 119 citations

A Poly(dA-dT) Upstream Activating Sequence Binds High-Mobility Group I Protein and Contributes to Lymphotoxin (Tumor Necrosis Factor-β) Gene Regulation

1992 • 115 citations

Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury

2006 • 114 citations

Genetic Studies of the Relationship of Tumour–Host Cells: Effect of Tumour Cells killed by X-rays upon the Growth of Admixed Viable Cells

1956 • 114 citations

Colon Cancer Cell-Derived High Mobility Group 1/Amphoterin Induces Growth Inhibition and Apoptosis in Macrophages

2005 • 112 citations

Upregulation of HMG1 Leads to Melanoma Inhibitory Activity Expression in Malignant Melanoma Cells and Contributes to Their Malignancy Phenotype

2003 • 112 citations

Round Window Membrane Delivery of l-Methionine Provides Protection from Cisplatin Ototoxicity Without Compromising Chemotherapeutic Efficacy

2001 • 105 citations

Neurite growth-promoting protein (amphoterin, p30) binds syndecan

1992 • 101 citations

Hmg4,a New Member of theHmg1/2Gene Family

1998 • 93 citations

Differences in the DNA‐Binding Properties of the Hmg‐Box Domains of HMG1 and the Sex‐Determining Factor SRY

1995 • 93 citations

HMGB1 interacts differentially with members of the Rel family of transcription factors

2003 • 93 citations

ADP-ribosylation of nonhistone high mobility group proteins in intact cells.

1983 • 91 citations

Nucleotide sequence of rat liver HMG1 cDNA

1987 • 88 citations

Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer

2006 • 87 citations

Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis

2003 • 87 citations

Receptor for age (RAGE) is a gene within the major histocompatibility class III region: implications for host response mechanisms in homeostasis and chronic disease

2001 • 80 citations

The Active Gene That Encodes Human High Mobility Group 1 Protein (HMG1) Contains Introns and Maps to Chromosome 13

1996 • 79 citations

Variation of HMGB1 expression in breast cancer.

2002 • 78 citations

Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer

2003 • 77 citations

Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells.

2004 • 75 citations

Transcription factors involved in development and progression of malignant melanoma.

2004 • 74 citations

Differences in the DNA-Binding Properties of the Hmg-Box Domains of HMG1 and the Sex-Determining Factor SRY

1995 • 71 citations

The discovery of thrombomodulin

2004 • 69 citations

Identification of melanoma inhibitory activity and other differentially expressed messenger RNAs in human melanoma cell lines with different metastatic capacity by messenger RNA differential display.

1995 • 66 citations

In vitro modulation of human melanoma cell invasion and proliferation by all-frans-retinoic acid

1998 • 66 citations

In Vitro Acetylation of HMGB-1 and -2 Proteins by CBP: the Role of the Acidic Tail

2004 • 66 citations

Transcriptional activation of the human HMG1 gene in cisplatin-resistant human cancer cells.

2001 • 64 citations

The Role of the C-terminal Extension (CTE) of the Estrogen Receptor α and β DNA Binding Domain in DNA Binding and Interaction with HMGB

2004 • 62 citations

In Vivo Acetylation of HMG1 Protein Enhances Its Binding Affinity to Distorted DNA Structures

2001 • 61 citations

Endogenous ADP ribosylation of high mobility group proteins 1 and 2 and histone H1 following DNA damage in intact cells

1985 • 61 citations

A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation.

1992 • 57 citations

High Mobility Group B Proteins Facilitate Strong Estrogen Receptor Binding to Classical and Half-Site Estrogen Response Elements and Relax Binding Selectivity

2004 • 56 citations

Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer

2004 • 54 citations

Cisplatin ototoxicity to the rat inner ear: A role for HMG1 and iNOS

2005 • 54 citations

Nucleotide sequence of a mouse cDNA encoding the non-histone chromosomal high mobility group protein-1 (HMG1)

1992 • 45 citations

High mobility group chromosomal proteins isolated from nuclei and cytosol of cultured hepatoma cells are similar

1980 • 44 citations

The Inhibitory Effect of HMGB-1 Protein on the Repair of Cisplatin-Damaged DNA Is Accomplished through the Acidic Domain

2005 • 38 citations

The human HMGB1 promoter is modulated by a silencer and an enhancer-containing intron

2001 • 27 citations

Characterization of a Transcription Factor Binding Site, Specifically Activating MIA Transcription in Melanoma

2000 • 25 citations

Differences between HMG1 proteins isolated from normal and tumour cells

1987 • 17 citations

Differences between some properties of acetylated and nonacetylated forms of HMG1 protein

1990 • 16 citations

Receptor for age RAGE is a gene within the major histocompatibility class III region implications for host response mechanisms in homeostasis and chronic disease

2001 • 12 citations

Response to Comment on “Cutting Edge: Extracellular High Mobility Group Box-1 Protein Is a Proangiogenic Cytokine”

2006 • 3 citations

Deleted Work

1955 • 0 citations